Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Roy D, Pan"'
Autor:
Aneta Turlik, Robert Damoiseaux, Joanna Li, Timothy R. Donahue, Daniel L. Sun, Selena Hernandez, Evan R. Abt, Wei Chen, Kendall N. Houk, Jeffrey I. Zink, Caius G. Radu, Andreea D. Stuparu, Karen Reue, Chi-An Cheng, Ethan W. Rosser, Johannes Czernin, Laurent Vergnes, Michael E. Jung, Christine E. Mona, Vincent Lok, Juno Van Valkenburgh, Xiaohong Chen, Roy D. Pan, Soumya Poddar, Thuc Le, Janet Song
Publikováno v:
RSC medicinal chemistry, vol 11, iss 3
A potent class of isoquinoline-based α-N-heterocyclic carboxaldehyde thiosemicarbazone (HCT) compounds has been rediscovered; based upon this scaffold, three series of antiproliferative agents were synthesized through iterative rounds of methylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c2c5577be17a8d967044dcbbd0e9db
https://escholarship.org/uc/item/37j7d1kf
https://escholarship.org/uc/item/37j7d1kf
Autor:
Daniel L, Sun, Soumya, Poddar, Roy D, Pan, Ethan W, Rosser, Evan R, Abt, Juno, Van Valkenburgh, Thuc M, Le, Vincent, Lok, Selena P, Hernandez, Janet, Song, Joanna, Li, Aneta, Turlik, Xiaohong, Chen, Chi-An, Cheng, Wei, Chen, Christine E, Mona, Andreea D, Stuparu, Laurent, Vergnes, Karen, Reue, Robert, Damoiseaux, Jeffrey I, Zink, Johannes, Czernin, Timothy R, Donahue, Kendall N, Houk, Michael E, Jung, Caius G, Radu
Publikováno v:
RSC Med Chem
A potent class of isoquinoline-based α-N-heterocyclic carboxaldehyde thiosemicarbazone (HCT) compounds has been rediscovered; based upon this scaffold, three series of antiproliferative agents were synthesized through iterative rounds of methylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b55a722fdd0d82b169a555313786e140
https://pubmed.ncbi.nlm.nih.gov/33479645
https://pubmed.ncbi.nlm.nih.gov/33479645
Autor:
Marilene B. Wang, Bruce Teter, Roy D. Pan, Edwin Chang, Jack Cipolla, Kym F. Faull, Haiqiang Wu, Sally A. Frautschy, Greg M. Cole, Alexander J. Yoon, Luis Z. Avila, Eri S. Srivatsan, Phillip D. Hampton, Saroj K. Basak
Publikováno v:
Analytical biochemistry. 596
A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342a8edef45ea0f132c241aeee01ad42
https://pubmed.ncbi.nlm.nih.gov/32081619
https://pubmed.ncbi.nlm.nih.gov/32081619
Publikováno v:
Angewandte Chemie. 131:1738-1740
Disclosed is a five-step synthesis of (±)-vibralactone, a biologically active terpenoid natural product. A key photochemical valence isomerization of 3-prenyl-pyran-2-one produces both the all-carbon quaternary stereocenter and the β-lactone at an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963465c1bbf6471ae4a586384ce7df36
https://doi.org/10.1002/ange.201812711
https://doi.org/10.1002/ange.201812711
Autor:
Osto C, Andreea D. Stuparu, Song J, Dalton Steele, Robert Damoiseaux, Sun D, Sheba Plamthottam, Wesley R Armstrong, Caius G. Radu, Van Valkenburgh J, Soumya Poddar, Selena Hernandez, Johannes Czernin, Ethan W. Rosser, Evan R. Abt, Joseph R. Capri, Karen Reue, Roy D. Pan, Anthony E. Cabebe, Jung M, Li J, Laurent Vergnes, Le T, Lok
The lead compound, an ⍺-N-heterocyclic carboxaldehyde thiosemicarbazone HCT-13, was highly potent against a panel of pancreatic, small cell lung carcinoma, and prostate cancer models, with IC90 values in the low-to-mid nanomolar range. We show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10edef0267dcd0c10135b4cccb0c87c2
https://doi.org/10.26434/chemrxiv.7877987
https://doi.org/10.26434/chemrxiv.7877987
Disclosed is a four-step synthesis of (±)-vibralactone, a biologically active terpenoid natural product. A key photochemical valence isomerization of 3-prenyl-pyran-2-one forges both the all-carbon quaternary stereocenter and the β-lactone at an ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55aac261f92ed9b20a6b905b6357096b
https://doi.org/10.26434/chemrxiv.7245167
https://doi.org/10.26434/chemrxiv.7245167