Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Roy Chun-Laam Ng"'
Autor:
Roy Chun-Laam Ng, Min Jian, Oscar Ka-Fai Ma, Ariya Weiman Xiang, Myriam Bunting, Jason Shing-Cheong Kwan, Curtis Wai-Kin Wong, Leung-Wah Yick, Sookja Kim Chung, Karen Siu-Ling Lam, Ian E. Alexander, Aimin Xu, Koon-Ho Chan
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Adiponectin (APN) is an adipokine which predominantly expresses in adipocytes with neuroprotective and anti-inflammatory effects. We have recently indicated that circulatory trimeric APN can enter the brain by crossing the blood–brain barr
Externí odkaz:
https://doaj.org/article/6eb49e54f24241c98ba0ec6dd4b65832
Autor:
Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the br
Externí odkaz:
https://doaj.org/article/6b764bb85ea2452a913aa80974bdc655
Autor:
Oscar Ka-Fai Ma, Simone Ronsisvalle, Livia Basile, Ariya Weiman Xiang, Cristina Tomasella, Federica Sipala, Matteo Pappalardo, Koon-Ho Chan, Danilo Milardi, Roy Chun-Laam Ng, Salvatore Guccione
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114141- (2023)
Diabetic neuropathy (DN) is a long-term complication of diabetes mellitus, affecting different periphery nerve systems including sensory and motor neurons. Hyperglycemia is the major cause of DN with symptoms such as weakness of balance or coordinati
Externí odkaz:
https://doaj.org/article/a7e57fb4ad034497b5235f94760f81be
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-19 (2019)
Abstract Background Microglia-mediated neuroinflammation is important in Alzheimer’s disease (AD) pathogenesis. Extracellular deposition of β-amyloid (Aβ), a major pathological hallmark of AD, can induce microglia activation. Adiponectin (APN), a
Externí odkaz:
https://doaj.org/article/c9b9947da2c14f84a6e7ae1a0733a277
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Neuromyelitis optica spectrum disorders (NMOSD) are central nervous system inflammatory disorders causing significant morbidities and mortality. The majority of NMOSD patients have autoimmunity against aquaporin-4 (AQP4), evidenced by seropositivity
Externí odkaz:
https://doaj.org/article/f96ee647d0404ed8af2cf7f27c773694
Autor:
Roy Chun-Laam Ng, Koon-Ho Chan
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 3, p 592 (2017)
The adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer’s
Externí odkaz:
https://doaj.org/article/6314793058ca4640aa3257e80745c9d7
Autor:
Chen Qian, Kenneth K. Y. Wong, Zhengwei Yuan, Roy Chun-Laam Ng, Paul K.H. Tam, Maria-Mercè Garcia-Barceló, Zhongluan Wu, Vincent C.H. Lui
Publikováno v:
Cell Death Differ
In mammals, urorectal development starts at early embryonic stage, defective urorectal development results in anorectal malformations, which are common congenital developmental defects of the anus and the urethra in newborns. The etiology and embryol
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-19 (2019)
Jian, M, Kwan, J S-C, Bunting, M, Ng, R C-L & Chan, K-H 2019, ' Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway ', Journal of Neuroinflammation, vol. 16, no. 1, 110 . https://doi.org/10.1186/s12974-019-1492-6
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-19 (2019)
Jian, M, Kwan, J S-C, Bunting, M, Ng, R C-L & Chan, K-H 2019, ' Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway ', Journal of Neuroinflammation, vol. 16, no. 1, 110 . https://doi.org/10.1186/s12974-019-1492-6
Background Microglia-mediated neuroinflammation is important in Alzheimer’s disease (AD) pathogenesis. Extracellular deposition of β-amyloid (Aβ), a major pathological hallmark of AD, can induce microglia activation. Adiponectin (APN), an adipocy
Autor:
Min Li, Ping-Kei Chan, Guang-Jie Zhou, Roy Chun-Laam Ng, Oscar Ka-Fai Ma, Krishnamoorthi Senthilkumar, Sookja K. Chung, Richard Festenstein, Koon-Ho Chan, Ashok Iyaswamy, Kenneth M.Y. Leung, J.S.C. Kwan, Myriam Bunting, Siva-Sundara Kumar Durairajan, Karen Siu-ling Lam, Leung-Wing Chu, Min Jian
Publikováno v:
Molecular psychiatry. 26(10)
Circulating adiponectin (APN) levels decrease with age and obesity. On the other hand, a reduction in APN levels is associated with neurodegeneration and neuroinflammation. We previously showed that aged adiponectin knockout (APN-/-) mice developed A
Autor:
Koon-Ho Chan, Roy Chun-Laam Ng
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 3, p 592 (2017)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer's di