Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Roy C, Orlando"'
Publikováno v:
Clinical and Experimental Gastroenterology, Vol 2010, Iss default, Pp 117-125 (2010)
Roy C Orlando1, Sherry Liu2, Marta Illueca31Department of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA, 2Department of Statistics and Informatics, 3Department of Clinical Development, AstraZeneca LP, Wilmington,
Externí odkaz:
https://doaj.org/article/68dbb45e2f344780a4452856f9f9431f
Autor:
Ryan Balfour Sartor, Melissa Ellermann, Nitsan Maharshak, Michael J. Shanahan, Zorka Djukic, Luke B. Borst, Lance R. Thurlow, Rafal Pawlinski, Ian M. Carroll, Siten Patel, Eun Young Huh, Jeremy Herzog, Roy C. Orlando, Chorlada Paiboonrungruang, Iris Dotan
Publikováno v:
Infection and Immunity. 83:2762-2770
Microbial protease-mediated disruption of the intestinal epithelium is a potential mechanism whereby a dysbiotic enteric microbiota can lead to disease. This mechanism was investigated using the colitogenic, protease-secreting enteric microbe Enteroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc68aff2033be5044850cc0c27f71a0b
https://doi.org/10.1128/iai.00425-15
https://doi.org/10.1128/iai.00425-15
Autor:
Craig C. Reed, Nicholas J. Shaheen, Zorka Djukic, Biljana Jovov, Geraldine S. Orlando, Roy C. Orlando, Kathleen Ferrell, Amy P. Pruitt
BACKGROUND: Approximately 20% of patients with heartburn and normal endoscopic findings do not symptomatically improve on proton pump inhibitor (PPI) therapy making diagnosis and treatment uncertain. A biomarker distinguishing PPI-responsive from PPI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71533fed6ea1006243a4a788eb9db6cc
https://europepmc.org/articles/PMC5823739/
https://europepmc.org/articles/PMC5823739/
Autor:
Roy C. Orlando
Publikováno v:
Digestive Diseases. 32:164-170
Background/Aims: Endoscopic radiofrequency ablation of dysplastic Barrett's esophagus (BE) combined with proton pump inhibitor therapy is commonly utilized for preventing progression of dysplastic BE to esophageal adenocarcinoma. Fundamental to the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f0599a1bd29fcf36be73ac314d14c7
https://doi.org/10.1159/000357185
https://doi.org/10.1159/000357185
Autor:
Carine Blanchard, J.P. Abonia, Evan S. Dellon, Zorka Djukic, Roy C. Orlando, M.S. Costello, Margaret H. Collins, Julie M. Caldwell, M.E. Rothenberg, Simon P. Hogan, Melissa K. Mingler, P.E. Putnam, Emily M. Stucke, K Kc, David Wu, Katherine A. Kemme, Joseph D. Sherrill
Publikováno v:
Mucosal immunology
The desmosomal cadherin desmoglein-1 (DSG1) is an essential intercellular adhesion molecule that is altered in various human cutaneous disorders; however, its regulation and function in allergic disease remains unexplored. Herein, we demonstrate a sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2edb5030d3cf5ba9c0afdf46227f72e
http://europepmc.org/articles/PMC3999291
http://europepmc.org/articles/PMC3999291
Autor:
Xiaoxin Luke Chen, Hao Chen, Nicholas J. Shaheen, Roy C. Orlando, Yu Fang, Jianguo Hu, Yuhui Hu, Zorka Djukic, Whitney Tevebaugh
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 305:G58-G65
The barrier function of the esophageal epithelium is a major defense against gastroesophageal reflux disease. Previous studies have shown that reflux damage is reflected in a decrease in transepithelial electrical resistance associated with tight jun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ec3670f29cdfabc7fdcd887833eb13
https://doi.org/10.1152/ajpgi.00438.2012
https://doi.org/10.1152/ajpgi.00438.2012
Autor:
Ryan D. Madanick, Cary C. Cotton, Roy C. Orlando, Melissa Spacek, Hannah P. Kim, William J. Bulsiewicz, Sarina Pasricha, Nicholas J. Shaheen, Susan Bream, Xiaoxin Chen, Evan S. Dellon
Publikováno v:
Clinical Gastroenterology and Hepatology. 11:636-642
Background & Aims The goal of radiofrequency ablation (RFA) for patients with Barrett's esophagus (BE) is to eliminate dysplasia and metaplasia. The efficacy and safety of RFA for patients with BE and neoplasia are characterized incompletely. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2069588e49a59583450708ee03b6d37
https://doi.org/10.1016/j.cgh.2012.10.028
https://doi.org/10.1016/j.cgh.2012.10.028
Autor:
Nicholas J. Shaheen, Mark Berner Hansen, Roy C. Orlando, Amy P. Pruitt, William J. Bulsiewicz
Publikováno v:
Digestive Diseases and Sciences. 58:1955-1959
Acid-sensing ion channels (ASICs) are esophageal nociceptors that are candidates to mediate heartburn in non-erosive reflux disease (NERD). Amiloride, a diuretic, is known to inhibit ASICs. For this reason, we sought a role for ASICs in mediating hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae73e0d8fad059b9f0a2534a5de2ec2b
https://doi.org/10.1007/s10620-013-2586-0
https://doi.org/10.1007/s10620-013-2586-0
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G1231-G1243
Several different cell culture systems and laboratory animal models have been used over the years to study Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Most of the existing models have key differences with the human esophagus and com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032bebc55550a7e28cc16bf395d6a90d
https://doi.org/10.1152/ajpgi.00509.2011
https://doi.org/10.1152/ajpgi.00509.2011
Publikováno v:
Digestive Diseases and Sciences. 56:3405-3420
Barrett’s esophagus (BE) is defined as metaplastic conversion of esophageal squamous epithelium to intestinalized columnar epithelium. As a premalignant lesion of esophageal adenocarcinoma (EAC), it develops as a result of chronic gastroesophageal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec1d6a8075ae8b516181afa2de08f6c
https://doi.org/10.1007/s10620-011-1885-6
https://doi.org/10.1007/s10620-011-1885-6