Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics.

Autor: Baek K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Metivier RJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Roy Burman SS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Bushman JW; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Yoon H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lumpkin RJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Abeja DM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA., Lakshminarayan M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA., Yue H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Ojeda S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Verano AL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Gray NS; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford Medical School, Stanford University, Stanford, CA, 94305, USA., Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.

Author Correction: Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.

Autor: Radko-Juettner S; Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.; St Jude Graduate School of Biomedical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA., Yue H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Myers JA; Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Carter RD; Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Robertson AN; Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Mittal P; Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Zhu Z; Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Hansen BS; Department of Cell and Molecular Biology, St Jude Children's Research Hospital, Memphis, TN, USA.; The Center for Advanced Genome Engineering, St Jude Children's Research Hospital, Memphis, TN, USA., Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Hunkeler M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Rosikiewicz W; Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA., Wu Z; Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA., McReynolds MG; Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA., Roy Burman SS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Schmoker AM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Mageed N; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Brown SA; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Mobley RJ; Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Partridge JF; Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Stewart EA; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.; Cancer Center, St Jude Children's Research Hospital, Memphis, TN, USA., Pruett-Miller SM; Department of Cell and Molecular Biology, St Jude Children's Research Hospital, Memphis, TN, USA.; The Center for Advanced Genome Engineering, St Jude Children's Research Hospital, Memphis, TN, USA., Nabet B; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Peng J; Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA., Gray NS; Department of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, Stanford Medicine, Stanford, CA, USA., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. eric_fischer@dfci.harvard.edu.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. eric_fischer@dfci.harvard.edu., Roberts CWM; Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA. charles.roberts@stjude.org.; Cancer Center, St Jude Children's Research Hospital, Memphis, TN, USA. charles.roberts@stjude.org.

Publikováno v: Nature [Nature] 2024 May; Vol. 629 (8012), pp. E12.

Continuous evolution of compact protein degradation tags regulated by selective molecular glues.

Autor: Mercer JAM; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., DeCarlo SJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Roy Burman SS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Sreekanth V; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA., Nelson AT; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Hunkeler M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Chen PJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Kokkonda P; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Tiwari PK; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA., Shoba VM; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Deb A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Mar 15; Vol. 383 (6688), pp. eadk4422. Date of Electronic Publication: 2024 Mar 15.

Structural basis of regulated m ⁷ G tRNA modification by METTL1-WDR4.

Autor: Li J; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Wang L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; School of Pharmaceutical Sciences, Wuhan University, Wuhan, China., Hahn Q; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Nowak RP; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Viennet T; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Orellana EA; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Roy Burman SS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Yue H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Hunkeler M; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Fontana P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Arthanari H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Fischer ES; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Gregory RI; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA. rgregory@enders.tch.harvard.edu.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. rgregory@enders.tch.harvard.edu.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA. rgregory@enders.tch.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. rgregory@enders.tch.harvard.edu.; Harvard Stem Cell Institute, Cambridge, MA, USA. rgregory@enders.tch.harvard.edu.; Harvard Initiative for RNA Medicine, Boston, MA, USA. rgregory@enders.tch.harvard.edu.

Publikováno v: Nature [Nature] 2023 Jan; Vol. 613 (7943), pp. 391-397. Date of Electronic Publication: 2023 Jan 04.

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks.

Autor: Koehler Leman J; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, 10010, USA. julia.koehler.leman@gmail.com.; Department of Biology, New York University, New York, NY, 10003, USA. julia.koehler.leman@gmail.com., Lyskov S; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA., Lewis SM; Cyrus Biotechnology, 1201 Second Ave, Suite 900, Seattle, WA, 98101, USA., Adolf-Bryfogle J; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA, 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research, La Jolla, CA, 92037, USA., Alford RF; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA., Barlow K; Graduate Program in Bioinformatics, University of California San Francisco, San Francisco, CA, 94158, USA., Ben-Aharon Z; Department of Microbiology and Molecular Genetics, Hebrew University, Hadassah Medical School, POB 12272, Jerusalem, 91120, Israel., Farrell D; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Fell J; Genome Center, University of California, Davis, CA, 95616, USA.; Department of Biochemistry & Molecular Medicine, University of California, Davis, CA, 95616, USA.; Department of Chemistry, University of California, Davis, CA, 95616, USA., Hansen WA; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08904, USA.; Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ, 08904, USA., Harmalkar A; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA., Jeliazkov J; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD, 21218, USA., Kuenze G; Department of Chemistry, Vanderbilt University, Nashville, TN, 37235, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN, 37235, USA.; Institute for Drug Discovery, Medical School, Leipzig University, 04103, Leipzig, Germany., Krys JD; Faculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland., Ljubetič A; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Loshbaugh AL; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Biophysics Graduate Program, University of California San Francisco, San Francisco, CA, 94158, USA., Maguire J; Program in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Moretti R; Department of Chemistry, Vanderbilt University, Nashville, TN, 37235, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN, 37235, USA., Mulligan VK; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, 10010, USA., Nance ML; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD, 21218, USA., Nguyen PT; Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA, 95616, USA., Ó Conchúir S; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94158, USA., Roy Burman SS; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA., Samanta R; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA., Smith ST; Center for Structural Biology, Vanderbilt University, Nashville, TN, 37235, USA.; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, 37235, USA., Teets F; Department of Bioochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA., Tiemann JKS; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, DK-2200, Copenhagen N., Denmark., Watkins A; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, 94305, USA., Woods H; Center for Structural Biology, Vanderbilt University, Nashville, TN, 37235, USA.; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, 37235, USA., Yachnin BJ; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08904, USA.; Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ, 08904, USA., Bahl CD; Institute for Protein Innovation, Boston, MA, 02115, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA., Bailey-Kellogg C; Department of Computer Science, Dartmouth, Hanover, NH, 03755, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Das R; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, 94305, USA., DiMaio F; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Khare SD; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08904, USA.; Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ, 08904, USA., Kortemme T; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Biophysics Graduate Program, University of California San Francisco, San Francisco, CA, 94158, USA., Labonte JW; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA., Lindorff-Larsen K; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, DK-2200, Copenhagen N., Denmark., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, TN, 37235, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN, 37235, USA.; Institute for Drug Discovery, Medical School, Leipzig University, 04103, Leipzig, Germany., Schief W; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA, 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research, La Jolla, CA, 92037, USA., Schueler-Furman O; Department of Microbiology and Molecular Genetics, Hebrew University, Hadassah Medical School, POB 12272, Jerusalem, 91120, Israel., Siegel JB; Genome Center, University of California, Davis, CA, 95616, USA.; Department of Biochemistry & Molecular Medicine, University of California, Davis, CA, 95616, USA.; Department of Chemistry, University of California, Davis, CA, 95616, USA., Stein A; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, DK-2200, Copenhagen N., Denmark., Yarov-Yarovoy V; Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA, 95616, USA., Kuhlman B; Department of Bioochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA., Leaver-Fay A; Department of Bioochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA., Gront D; Faculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland., Gray JJ; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA. jgray@jhu.edu., Bonneau R; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, 10010, USA. bonneau@nyu.edu.; Department of Biology, New York University, New York, NY, 10003, USA. bonneau@nyu.edu.; Department of Computer Science, New York University, New York, NY, 10003, USA. bonneau@nyu.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 29; Vol. 12 (1), pp. 6947. Date of Electronic Publication: 2021 Nov 29.