Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Roy A. Mariuzza"'
Autor:
Matthew C. Metcalf, Benjamin M. Janus, Rui Yin, Ruixue Wang, Johnathan D. Guest, Edwin Pozharski, Mansun Law, Roy A. Mariuzza, Eric A. Toth, Brian G. Pierce, Thomas R. Fuerst, Gilad Ofek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV-neutralizing antibodies is the membrane-associated E1E2 sur
Externí odkaz:
https://doaj.org/article/5c8f3813e8b4474bb3fa9ada06482823
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Adoptive cell therapy (ACT) with tumor-specific T cells has been shown to mediate durable cancer regression. Tumor-specific T cells are also the basis of other therapies, notably cancer vaccines. The main target of tumor-specific T cells are neoantig
Externí odkaz:
https://doaj.org/article/77ed598acda54e73a773868631ad76f2
Autor:
Muaz Nik Rushdi, Victor Pan, Kaitao Li, Hyun-Kyu Choi, Stefano Travaglino, Jinsung Hong, Fletcher Griffitts, Pragati Agnihotri, Roy A. Mariuzza, Yonggang Ke, Cheng Zhu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
It is known that the T cell co-receptor CD4 greatly enhances the capacity of T cell receptor (TCR) signalling, triggered by the peptide-bound MHC molecule. Here authors show that the mechanistic basis for the enhancement is the co-operative binding o
Externí odkaz:
https://doaj.org/article/2859ebb5eb6e4438bdcbb90534f57bee
Autor:
Daichao Wu, Alexander Kolesnikov, Rui Yin, Johnathan D. Guest, Ragul Gowthaman, Anton Shmelev, Yana Serdyuk, Dmitry V. Dianov, Grigory A. Efimov, Brian G. Pierce, Roy A. Mariuzza
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Structural immunology is critical in understanding the interplay between the immune response and the infective agent but such studies in T cells and SARS-CoV-2 lag behind those of antibodies and B-cell receptors. Here the authors assess recognition o
Externí odkaz:
https://doaj.org/article/88ff2336853b4fc5ae388f4cc35fedd1
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Developing broadly applicable neoantigen-directed adoptive cell therapies (ACTs) is challenging because each cancer patient has an unique neoantigen repertoire. Here, the authors present the crystal structures of tumor-specific T cell receptors (TCRs
Externí odkaz:
https://doaj.org/article/539421cdbf2649ba84e049f00249ee1a
Autor:
Shu Shun Li, Henry Ogbomo, Michael K. Mansour, Richard F. Xiang, Lian Szabo, Fay Munro, Priyanka Mukherjee, Roy A. Mariuzza, Matthias Amrein, Jatin M. Vyas, Stephen M. Robbins, Christopher H. Mody
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Natural killer (NK) cells has been show to mediate fungi killing via the activating receptor NKp30, but the fungal target for NKp30 is still unclear. Here the authors show, using atomic force microscopy and live cell imaging, that β-1,3-glucan is ex
Externí odkaz:
https://doaj.org/article/2544882c0af34f56b6d9c66dfded2082
Autor:
Guobing Chen, Xinbo Yang, Annette Ko, Xiaoping Sun, Mingming Gao, Yongqing Zhang, Alvin Shi, Roy A. Mariuzza, Nan-ping Weng
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 569-583 (2017)
Summary: A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections. However, information about TCR repertoires to defined viral antigens is limited. We performed a comprehensive analysis of CD8+ TCR repertoires for two
Externí odkaz:
https://doaj.org/article/376bc7f7e0154f67bce4914b17bff2f6
Autor:
Arjun K. Mishra, Roy A. Mariuzza
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Affinity maturation is the process whereby the immune system generates antibodies of higher affinities during a response to antigen. It is unique in being the only evolutionary mechanism known to operate on a molecule in an organism’s own body. Dec
Externí odkaz:
https://doaj.org/article/ee0720a70a584c4b846949a1e7710f5c
Autor:
Jeff Quigley, V. Keith Hughitt, Carlos A. Velikovsky, Roy A. Mariuzza, Najib M. El-Sayed, Volker Briken
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT The cell wall of Mycobacterium tuberculosis is composed of unique lipids that are important for pathogenesis. Indeed, the first-ever genetic screen in M. tuberculosis identified genes involved in the biosynthesis and transport of the cell wa
Externí odkaz:
https://doaj.org/article/0e3bad085cc34cf9b1eece179b714cd2
Autor:
Sharanbasappa S. Karade, Evelyn J. Franco, Ana C. Rojas, Kaley C. Hanrahan, Alexander Kolesnikov, Wenbo Yu, Alexander D. MacKerell, Daniel C. Hill, David J. Weber, Ashley N. Brown, Anthony M. Treston, Roy A. Mariuzza
Publikováno v:
Journal of Medicinal Chemistry. 66:2744-2760