Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Roy A. Frye"'
Autor:
David A. Sinclair, Haim Y. Cohen, Roy A. Frye, Benedikt M. Kessler, Brian G Hekking, Siva Lavu, Thomas A Imahiyerobo, Kevin J. Bitterman, Christine M. Miller, Hidde L. Ploegh
Apoptosis is a key tumor suppression mechanism that can be initiated by activation of the proapoptotic factor Bax. The Ku70 DNA end-joining protein has recently been shown to suppress apoptosis by sequestering Bax from mitochondria. The mechanism by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f097c732baf02051db32f68fc2ce222d
https://ora.ox.ac.uk/objects/uuid:7988c853-6462-484a-b61a-ae22b0e0cd9b
https://ora.ox.ac.uk/objects/uuid:7988c853-6462-484a-b61a-ae22b0e0cd9b
Autor:
Roy A. Frye, Michael D Keller, David R. Jones, Marty W. Mayo, Catherine S. Ramsey, Jamie E. Hoberg, Fan Yeung
Publikováno v:
The EMBO Journal. 23:2369-2380
NF-kappaB is responsible for upregulating gene products that control cell survival. In this study, we demonstrate that SIRT1, a nicotinamide adenosine dinucleotide-dependent histone deacetylase, regulates the transcriptional activity of NF-kappaB. SI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a59ea34d24e33bf70e5547ef0dbfa5c
https://doi.org/10.1038/sj.emboj.7600244
https://doi.org/10.1038/sj.emboj.7600244
Autor:
Valerie J. Peterson, Mark Leid, David M. Shepherd, Dorina Avram, Saverio Minucci, Thanaset Senawong, Roy A. Frye
Publikováno v:
Journal of Biological Chemistry. 278:43041-43050
Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting proteins 1 and 2 (CTIP1 and CTIP2) enhance transcriptional repression mediated by COUP-TF II and have been implicated in hematopoietic cell development and malignancies. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282986a874e53e51b5b18dd99a072750
https://doi.org/10.1074/jbc.m307477200
https://doi.org/10.1074/jbc.m307477200
Publikováno v:
The Journal of cell biology, vol 158, iss 4
The Journal of Cell Biology
The Journal of Cell Biology
The yeast silent information regulator (Sir)2 protein links cellular metabolism and transcriptional silencing through its nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase activity. We report that mitochondria from mammalian cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42e7ad5c007f0f007d9283670d555ff
https://doi.org/10.1083/jcb.200205057
https://doi.org/10.1083/jcb.200205057
Autor:
Roy A. Frye, Shin-ichiro Imai, Scott K. Dessain, Tej K. Pandita, Elinor Ng Eaton, Robert A. Weinberg, Leonard Guarente, Homayoun Vaziri
Publikováno v:
Cell. 107:149-159
DNA damage-induced acetylation of p53 protein leads to its activation and either growth arrest or apoptosis. We show here that the protein product of the gene hSIR2SIRT1, the human homolog of the S. cerevisiae Sir2 protein known to be involved in cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dbddddfa4b17cd22b3559d0186aea7
https://doi.org/10.1016/s0092-8674(01)00527-x
https://doi.org/10.1016/s0092-8674(01)00527-x
Autor:
Roy A. Frye
Publikováno v:
Biochemical and Biophysical Research Communications. 260:273-279
The yeast Sir2 protein regulates epigenetic gene silencing and as a possible antiaging effect it suppresses recombination of rDNA. Studies involving cobB, a bacterial SIR2-like gene, have suggested it could encode a pyridine nucleotide transferase. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4012e9ce0d662b0838c8e032cb4c9ed
https://doi.org/10.1006/bbrc.1999.0897
https://doi.org/10.1006/bbrc.1999.0897
Autor:
Roy A. Frye
Publikováno v:
Nature Precedings
Ethnic populations representing areas throughout California were compared regarding cognitive ability, socioeconomic position, and mortality. Cognition and socioeconomic position were inversely correlated with mortality. The single nucleotide polymor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfc21b8ce71f377ca8aee5c03c64f81
https://doi.org/10.1038/npre.2009.2862.1
https://doi.org/10.1038/npre.2009.2862.1
Hepatic iron content and the risk of Staphylococcus aureus bacteremia in liver transplant recipients
Autor:
Mohamed Akoad, Lisa Tickerhoof, Debra Mayher, Marilyn M. Wagener, Thomas V. Cacciarelli, Cheryl Wannstedt, Lois Keyes, Roy A. Frye, Nina Singh
Publikováno v:
Progress in transplantation (Aliso Viejo, Calif.). 17(4)
Iron is a critical nutrient source and contributes to staphylococcal pathogenesis. We assessed the role of hepatic explant iron overload as a risk factor for Staphylococcus aureus bacteremia in liver transplant recipients. Seven of 13 cases with S au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0482ffc592ce5cbaaa028f149eeb46d
https://pubmed.ncbi.nlm.nih.gov/18240700
https://pubmed.ncbi.nlm.nih.gov/18240700
Publikováno v:
International journal of dermatology. 45(3)
Background Prodromal bullous pemphigoid (PBP) can be difficult to diagnose. Early recognition in its early stages may decrease the morbidity and progression of the disease. Clinical presentations and current treatments available for PBP will be descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909e08b3b29c6249e1e5fba327f65734
https://pubmed.ncbi.nlm.nih.gov/16533217
https://pubmed.ncbi.nlm.nih.gov/16533217
Autor:
Roy A. Frye
Publikováno v:
Histone Deacetylases ISBN: 9781588294999
Most eukaryotic sirtuins (sir2-like proteins) can be grouped into four classes. In deuterostomes such as vertebrates, the urochordate sea squirt Ciona, and the echinoderm sea urchin Strongylocentrotus, there are seven sirtuins. Class I includes SIRT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a18d6bc98927cf4c23645a427323b2dc
https://doi.org/10.1385/1-59745-024-3:183
https://doi.org/10.1385/1-59745-024-3:183