Výsledky vyhledávání - "Roy A. Black"

Akademický článek

A Self-Assembled Aggregate Composed of a Fatty Acid Membrane and the Building Blocks of Biological Polymers Provides a First Step in the Emergence of Protocells

Autor: Roy A. Black, Matthew C. Blosser

Publikováno v: Life, Vol 6, Iss 3, p 33 (2016)

We propose that the first step in the origin of cellular life on Earth was the self-assembly of fatty acids with the building blocks of RNA and protein, resulting in a stable aggregate. This scheme provides explanations for the selection and concentr

Externí odkaz: https://doaj.org/article/dfed88ec8d29484bb3f33ef3a8414c3a

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Plausible Sources of Membrane-Forming Fatty Acids on the Early Earth: A Review of the Literature and an Estimation of Amounts

Autor: Zachary R. Cohen, Zoe R. Todd, Nicholas Wogan, Roy A. Black, Sarah L. Keller, David C. Catling

Publikováno v: ACS Earth and Space Chemistry. 7:11-27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::467f8669424a68aa0d1f927d457f1ba5
https://doi.org/10.1021/acsearthspacechem.2c00168

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Growth of Prebiotically Plausible Fatty Acid Vesicles Proceeds in the Presence of Prebiotic Amino Acids, Dipeptides, Sugars, and Nucleic Acid Components

Autor: Zoe R. Todd, Zachary R. Cohen, David C. Catling, Sarah L. Keller, Roy A. Black

Publikováno v: Langmuir. 38:15106-15112

Fatty acid vesicles may have played a role in the origin of life as a major structural component of protocells, with the potential for encapsulation of genetic materials. Vesicles that grew and divided more rapidly than other vesicles could have had

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17c2ea891c873dff544ebcd1e2d3cee
https://doi.org/10.1021/acs.langmuir.2c02118

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Prebiotic Protocell Membranes Retain Encapsulated Contents during Flocculation, and Phospholipids Preserve Encapsulation during Dehydration

Autor: Zachary R. Cohen, Caitlin. E. Cornell, David C. Catling, Roy A. Black, Sarah L. Keller

Publikováno v: Langmuir. 38:1304-1310

The first cell membranes were likely composed of single-chain amphiphiles such as fatty acids. An open question is whether fatty acid membranes could have functioned within evaporative lakes on the early Earth, which have been hypothesized to concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b7f20d629f2c70ef814b52caab70b5
https://doi.org/10.1021/acs.langmuir.1c03296

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Prebiotic Vesicles Retain Solutes and Grow by Micelle Addition after Brief Cooling below the Membrane Melting Temperature

Autor: Zachary R. Cohen, Zoe R. Todd, David C. Catling, Roy A. Black, Sarah L. Keller

Publikováno v: Langmuir : the ACS journal of surfaces and colloids. 38(44)

Replication of RNA genomes within membrane vesicles may have been a critical step in the development of protocells on the early Earth. Cold temperatures near 0 °C improve the stability of RNA and allow efficient copying, while some climate models su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4d869bc23342712037b0da257e3c5d
https://pubmed.ncbi.nlm.nih.gov/36278967

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Prebiotic Membranes and Micelles Do Not Inhibit Peptide Formation During Dehydration

Autor: Zachary R. Cohen, Brennan L. Kessenich, Avijit Hazra, Julia Nguyen, Richard S. Johnson, Michael J. MacCoss, Gojko Lalic, Roy A. Black, Sarah L. Keller

Publikováno v: Chembiochem

Cycles of dehydration and rehydration could have enabled formation of peptides and RNA in otherwise unfavorable conditions on the early Earth. Development of the first protocells would have hinged upon colocalization of these biopolymers with fatty a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf8042088a9c84a28340944ee29d4ae
https://europepmc.org/articles/PMC8957845/

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Binding of Dipeptides to Fatty Acid Membranes Explains Their Colocalization in Protocells, but Does Not Select for Them Relative to Unjoined Amino Acids

Autor: Zachary R. Cohen, Adrienne Roehrich, Roy A. Black, Gary P. Drobny, Sarah L. Keller, Mengjun Xue

Publikováno v: J Phys Chem B

Dipeptides, which consist of two amino acids joined by a peptide bond, have been shown to have catalytic function. This observation leads to fundamental questions relevant to the origins of life. How could peptides have become co-localized with the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3054b4c04410fbf746c5923242660bd
https://europepmc.org/articles/PMC8323988/

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Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes

Autor: Helen E Litz, Mengjun Xue, Zachary R. Cohen, Roy A. Black, Sarah L. Keller, Moshe T. Gordon, James A. Williams, Gary P. Drobny, Caitlin E. Cornell, Kelly K. Lee, Alexander Mileant, Andrew Ramsay

Publikováno v: Proceedings of the National Academy of Sciences. 116:17239-17244

The membranes of the first protocells on the early Earth were likely self-assembled from fatty acids. A major challenge in understanding how protocells could have arisen and withstood changes in their environment is that fatty acid membranes are unst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c726a9fad8f717b0fa5a1017c3bfb15
https://doi.org/10.1073/pnas.1900275116

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