Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Roy, Zent"'
Autor:
Daisuke Katagiri, Shinya Nagasaka, Keiko Takahashi, Suwan Wang, Ambra Pozzi, Roy Zent, Akira Shimizu, Ming-Zhi Zhang, Joachim R. Göthert, Toin H. van Kuppevelt, Raymond C. Harris, Takamune Takahashi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract The pivotal role of endothelial nitric oxide synthase (eNOS) in diabetic nephropathy (DN) has been demonstrated using global eNOS knockout (eNOSGKO) mice. However, the precise role of endothelially expressed eNOS and how its deficiency advan
Externí odkaz:
https://doaj.org/article/125f4f510b7148eca883ffbfed925244
Autor:
Lisa Tucker, Umer Ali, Roy Zent, Deborah A. Lannigan, Jeffrey C. Rathmell, Venkataswarup Tiriveedhi
Publikováno v:
Cells, Vol 13, Iss 11, p 912 (2024)
Several chronic inflammatory diseases have been linked to high-salt (HS) diets. Chronic inflammation is an established causative hallmark of cancer. However, a direct role of HS diets in tumorigenesis is yet to be defined. Previous orthotopic murine
Externí odkaz:
https://doaj.org/article/0629d031c7a04701a585edf9b85fcd7f
Autor:
Qionghong Xie, Min Zhang, Xiaoyi Mao, Mingyue Xu, Shaojun Liu, Da Shang, Yunyu Xu, Ruiying Chen, Yi Guan, Xinzhong Huang, Roy Zent, Ambra Pozzi, Chuan-Ming Hao
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-14 (2022)
Abstract Accumulating evidence indicates that the extracellular matrix (ECM) is not only a consequence of fibrosis, but also contributes to the progression of fibrosis, by creating a profibrotic microenvironment. Tenascin-C (TNC) is an ECM glycoprote
Externí odkaz:
https://doaj.org/article/153cf7e2b82946bdb2ae7299b7f576f8
Autor:
Jennifer M.S. Sucre, Fabian Bock, Nicholas M. Negretti, John T. Benjamin, Peter M. Gulleman, Xinyu Dong, Kimberly T. Ferguson, Christopher S. Jetter, Wei Han, Yang Liu, Seunghyi Kook, Jason J. Gokey, Susan H. Guttentag, Jonathan A. Kropski, Timothy S. Blackwell, Roy Zent, Erin J. Plosa
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
During alveolar repair, alveolar type 2 (AT2) epithelial cell progenitors rapidly proliferate and differentiate into flat AT1 epithelial cells. Failure of normal alveolar repair mechanisms can lead to loss of alveolar structure (emphysema) or develop
Externí odkaz:
https://doaj.org/article/39a9e420f73c4111974b87e317b6ae4c
Autor:
Kensei Taguchi, Bertha C. Elias, Sho Sugahara, Snehal Sant, Benjamin S. Freedman, Sushrut S. Waikar, Ambra Pozzi, Roy Zent, Raymond C. Harris, Samir M. Parikh, Craig R. Brooks
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Acute kidney injury (AKI) occurs in approximately 13% of hospitalized patients and predisposes patients to chronic kidney disease (CKD) through the AKI-to-CKD transition. Studies from our laboratory and others have demonstrated that maladaptive repai
Externí odkaz:
https://doaj.org/article/39476cd2216a4f49b97538bd93095fed
Autor:
Juan Pablo Arroyo, Andrew S. Terker, Yvonne Zuchowski, Jason A. Watts, Fabian Bock, Cameron Meyer, Wentian Luo, Meghan E. Kapp, Edward R. Gould, Adam X. Miranda, Joshua Carty, Ming Jiang, Roberto M. Vanacore, Elizabeth Hammock, Matthew H. Wilson, Roy Zent, Mingzhi Zhang, Gautam Bhave, Raymond C. Harris
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Vasopressin has traditionally been thought to be produced by the neurohypophyseal system and then released into the circulation where it regulates water homeostasis. The questions of whether vasopressin could be produced outside of the brain and if t
Externí odkaz:
https://doaj.org/article/f8605fcd021d471dad0702e94a5d9ab1
Autor:
Scott M. Haake, Erin J. Plosa, Jonathan A. Kropski, Lindsay A. Venton, Anupama Reddy, Fabian Bock, Betty T. Chang, Allen J. Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A. Prather, Sharon Lee, Harikrishna Tanjore, Vasiliy V. Polosukhin, Olga M. Viquez, Angela Jones, Wentian Luo, Matthew H. Wilson, W. Kimryn Rathmell, Pierre P. Massion, Ambra Pozzi, Timothy S. Blackwell, Roy Zent
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Integrins — the principal extracellular matrix (ECM) receptors of the cell — promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis. To date, most integrin-targeted cancer therapeutics have disr
Externí odkaz:
https://doaj.org/article/265f440d006847c6922cd3a32eff3553
Autor:
Irma Adele Maré, Beverley Kramer, Scott Hazelhurst, Mapule Dorcus Nhlapho, Roy Zent, Paul A Harris, Michael Klipin
Publikováno v:
JMIR Medical Informatics, Vol 10, Iss 8, p e33402 (2022)
BackgroundElectronic data capture (EDC) in academic health care organizations provides an opportunity for the management, aggregation, and secondary use of research and clinical data. It is especially important in resource-constrained environments su
Externí odkaz:
https://doaj.org/article/4418b5f8a5314df6b914107d6ec93736
Autor:
Balawant Kumar, Rizwan Ahmad, Giovanna A. Giannico, Roy Zent, Geoffrey A. Talmon, Raymond C. Harris, Peter E. Clark, Vinata Lokeshwar, Punita Dhawan, Amar B. Singh
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Abstract Background Claudin-2 expression is upregulated in multiple cancers and promotes cancer malignancy. Remarkably, the regulation of claudin-2 expression in kidney cell lines contrasts its reported regulation in other organs. However, claudin-2
Externí odkaz:
https://doaj.org/article/ca0bad1ca624408989451271e8064bf3
Autor:
Corina M. Borza, Gema Bolas, Xiuqi Zhang, Mary Beth Browning Monroe, Ming-Zhi Zhang, Jens Meiler, Marcin J. Skwark, Raymond C. Harris, Lynne A. Lapierre, James R. Goldenring, Magnus Hook, Jose Rivera, Kyle L. Brown, Birgit Leitinger, Matthew J. Tyska, Markus Moser, Ralph T. Böttcher, Roy Zent, Ambra Pozzi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Integrins and discoidin domain receptors (DDRs) 1 and 2 promote cell adhesion and migration on both fibrillar and non fibrillar collagens. Collagen I contains DDR and integrin selective binding motifs; however, the relative contribution of these two
Externí odkaz:
https://doaj.org/article/74212c9411584149b4f85c2153ca6021