Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Roy, Helmy"'
Autor:
Huifang Yao, Edward C. Sherer, Mei Lu, James Small, Gary E. Martin, Yu-hong Lam, Qinghao Chen, Roy Helmy, Yong Liu, Hao Chen
Publikováno v:
The Journal of Organic Chemistry. 87:15011-15021
Synthesis of drug metabolites, which often have complex structures, is an integral step in the evaluation of drug candidate metabolism, pharmacokinetic (PK) properties, and safety profiles. Frequently, such synthetic endeavors entail arduous, multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d8065461c89a075285cc9907b3b8a8
https://doi.org/10.1021/acs.joc.2c01311
https://doi.org/10.1021/acs.joc.2c01311
Autor:
Ying Homan, Daniel Rosenbloom, Sally Wong, James Lucchese, April Li, Sheri Dubey, Justina Thomas, Gino Salituro, Roy Helmy, Thorsten Verch
Publikováno v:
Bioanalysis. 14:1177-1190
Aim: Critical virus reagents in regulated bioanalytical assays require stability monitoring. Although stability at ultra-low frozen temperatures is generally assumed, published data are limited and real-time studies are time consuming. Materials & me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0436aa69501fd394bab096d3b9a36c2b
https://doi.org/10.4155/bio-2022-0101
https://doi.org/10.4155/bio-2022-0101
Publikováno v:
Chirality. 34:856-863
Stereochemical quality control for pharmaceutical drug substance intermediates is a daunting task, especially considering the need to separate multiple stereoisomers simultaneously with low ppm level sensitivity. To address these challenges, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39a60b58f41d5c193793fc3b0d6c822
https://doi.org/10.1002/chir.23435
https://doi.org/10.1002/chir.23435
Autor:
Dilki Wickramarachchi, Julianne Wagner, Thomas Woo, Federico Ferrari, Thomas Steinmetz, Roy Helmy, Weifeng Xu
Publikováno v:
The AAPS Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22300e3a1a72eee11a84bddacf388f6d
https://doi.org/10.1208/s12248-023-00783-9
https://doi.org/10.1208/s12248-023-00783-9
Autor:
Chunhui Huang, Christian Fischer, Michelle R. Machacek, Stephane Bogen, Tesfaye Biftu, Xianhai Huang, Michael H. Reutershan, Ryan Otte, Qingmei Hong, Zhicai Wu, Yang Yu, Min Park, Lei Chen, Purakkattle Biju, Ian Knemeyer, Ping Lu, Christopher J. Kochansky, Michael Brendan Hicks, Yong Liu, Roy Helmy, Xavier Fradera, Anthony Donofrio, Josh Close, Matthew L. Maddess, Catherine White, David L. Sloman, Nunzio Sciammetta, Jun Lu, Craig Gibeau, Vladimir Simov, Hongjun Zhang, Peter Fuller, David Witter
Publikováno v:
ACS Med Chem Lett
[Image: see text] Mutant isocitrate dehydrogenase 1 (IDH1) has been identified as an attractive oncology target for which >70% of grade II and III gliomas and ∼10% of acute myeloid leukemia (AML) harbor somatic IDH1 mutations. These mutations confe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ecfd534a4182e5c705a82b16c3ffcc
https://europepmc.org/articles/PMC9014435/
https://europepmc.org/articles/PMC9014435/
Publikováno v:
Journal of Chromatography A. 1601:145-154
RNA interference offers a novel approach for the development of new therapeutics for targets that are otherwise "undruggable" using traditional modalities. The safety and efficacy of siRNA-based therapy mainly rely on lipid or polymer-based nanocarri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8d89a1cc9ce288a458b52df8b08a67
https://doi.org/10.1016/j.chroma.2019.04.061
https://doi.org/10.1016/j.chroma.2019.04.061
Autor:
Roy Helmy, W. Peter Wuelfing, Kausik K. Nanda, Olivier Mozziconacci, James H. Small, Leonardo R. Allain
Publikováno v:
Journal of Pharmaceutical Sciences. 108:1466-1475
The ability to produce and isolate relatively pure amounts of relevant degradation products is key to several aspects of drug product development: (a) aid in the unambiguous structural identification of such degradation products, fulfilling regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f96cda9c569fad829e044bfb260912
https://doi.org/10.1016/j.xphs.2018.10.059
https://doi.org/10.1016/j.xphs.2018.10.059
Publikováno v:
Journal of Pharmaceutical Sciences. 108:1172-1176
This article describes how the increased use of energy-efficient solid-state light sources (e.g., light-emitting diode [LED]-based illumination) in hospitals, pharmacies, and at home can help alleviate concerns of photodegradation for pharmaceuticals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3625ed1559f319c6911d220c3d9f00b3
https://doi.org/10.1016/j.xphs.2018.10.003
https://doi.org/10.1016/j.xphs.2018.10.003
Autor:
Alena Bensussan, Roy Helmy, Bindesh Shrestha, Hernando J. Olivos, Vivek Shah, Elizabeth E. Pierson, William P. Forrest, Ryan S. Teller, Anthony J. Midey, Seth P. Forster
Publikováno v:
Pharmaceutical Research. 37
Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) coupled with gas-phase ion mobility spectrometry was used to characterize the drug distribution in polymeric implants before and after exposure to accelerated in vitro release (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3987547d67cbf25a8f0ff3451cf677a
https://doi.org/10.1007/s11095-020-02823-x
https://doi.org/10.1007/s11095-020-02823-x
Autor:
Peter G. Dormer, W. Peter Wuelfing, Mikhail Reibarkh, William P. Forrest, Roy Helmy, Paul L. Walsh, Nathan D. Rudd, R. Thomas Williamson
Publikováno v:
Molecular Pharmaceutics.
Novel treatment routes are emerging for an array of diseases and afflictions. Complex dosage forms, based on active pharmaceutical ingredients (APIs) with previously undesirable physicochemical characteristics, are becoming mainstream and actively pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd781831ec8682b38df97d44b8a675db
https://doi.org/10.1021/acs.molpharmaceut.9b00958
https://doi.org/10.1021/acs.molpharmaceut.9b00958