Low-toxin Clostridioides difficile RT027 strains exhibit robust virulence.

Autor: Anwar F; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Roxas BAP; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Shehab KW; Department of Pediatrics, The University of Arizona College of Medicine, Tucson, AZ, USA., Ampel NM; Infectious Diseases, Mayo Clinic, Phoenix, AZ, USA., Viswanathan VK; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA.; Department of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ, USA.; BIO5 Institute for Collaborative Research, The University of Arizona, Tucson, AZ, USA., Vedantam G; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA.; Department of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ, USA.; BIO5 Institute for Collaborative Research, The University of Arizona, Tucson, AZ, USA.; Research Service, Southern Arizona VA Healthcare System, Tucson, AZ, USA.

Publikováno v: Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 1982-1993.

Phylogenomic analysis of Clostridioides difficile ribotype 106 strains reveals novel genetic islands and emergent phenotypes.

Autor: Roxas BAP; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Roxas JL; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Claus-Walker R; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Harishankar A; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Mansoor A; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Anwar F; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Jillella S; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Williams A; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Lindsey J; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA., Elliott SP; Department of Pediatrics, The University of Arizona College of Medicine, Tucson, AZ, USA., Shehab KW; Department of Pediatrics, The University of Arizona College of Medicine, Tucson, AZ, USA., Viswanathan VK; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA.; Department of Immunobiology, The University of Arizona, Tucson, AZ, USA.; Bio5 Institute for Collaborative Research, The University of Arizona, Tucson, AZ, USA., Vedantam G; School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, USA. gayatri@arizona.edu.; Department of Immunobiology, The University of Arizona, Tucson, AZ, USA. gayatri@arizona.edu.; Bio5 Institute for Collaborative Research, The University of Arizona, Tucson, AZ, USA. gayatri@arizona.edu.; Southern Arizona VA Health Care System, Tucson, AZ, USA. gayatri@arizona.edu.; School of Animal and Comparative Biomedical Sciences, University of Arizona, 1117 E Lowell St, Bldg. 90, Room 227, Tucson, AZ, 85721, USA. gayatri@arizona.edu.

Publikováno v: Scientific reports [Sci Rep] 2020 Dec 17; Vol. 10 (1), pp. 22135. Date of Electronic Publication: 2020 Dec 17.

Enteropathogenic Escherichia coli EspH-Mediated Rho GTPase Inhibition Results in Desmosomal Perturbations.

Autor: Roxas JL; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona., Monasky RC; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona., Roxas BAP; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona., Agellon AB; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.; BIO5 Institute for Collaborative Research, University of Arizona, Tucson, Arizona., Mansoor A; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona., Kaper JB; University of Maryland School of Medicine, Baltimore, Maryland., Vedantam G; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.; BIO5 Institute for Collaborative Research, University of Arizona, Tucson, Arizona.; Department of Immunobiology, University of Arizona, Tucson, Arizona.; Southern Arizona VA Healthcare System, Tucson, Arizona., Viswanathan VK; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.; BIO5 Institute for Collaborative Research, University of Arizona, Tucson, Arizona.; Department of Immunobiology, University of Arizona, Tucson, Arizona.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2018 Apr 27; Vol. 6 (2), pp. 163-180. Date of Electronic Publication: 2018 Apr 27 (Print Publication: 2018).

An intact S-layer is advantageous to Clostridioides difficile within the host.

Autor: Ormsby, Michael J.¹ (AUTHOR), Vaz, Filipa¹ (AUTHOR), Kirk, Joseph A.² (AUTHOR), Barwinska-Sendra, Anna³ (AUTHOR), Hallam, Jennifer C.¹ (AUTHOR), Lanzoni-Mangutchi, Paola³ (AUTHOR), Cole, John¹ (AUTHOR), Chaudhuri, Roy R.² (AUTHOR), Salgado, Paula S.³ (AUTHOR), Fagan, Robert P.² (AUTHOR), Douce, Gillian R¹ (AUTHOR) Gillian.Douce@glasgow.ac.uk

Publikováno v: PLoS Pathogens. 6/29/2023, Vol. 18 Issue 6, p1-26. 26p.

Clostridioides difficile-mucus interactions encompass shifts in gene expression, metabolism, and biofilm formation.

Autor: Furtado, Kathleen L., Plott, Lucas, Markovetz, Matthew, Powers, Deborah, Hao Wang, Hill, David B., Papin, Jason, Allbritton, Nancy L., Tamayo, Rita

Publikováno v: MSphere; Jun2024, Vol. 9 Issue 6, p1-21, 21p