Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Roxanne K Barrow"'
Autor:
Nikolas Nikolaidis, Dimitra Chalkia, D Neil Watkins, Roxanne K Barrow, Solomon H Snyder, Damian B van Rossum, Randen L Patterson
Publikováno v:
PLoS ONE, Vol 2, Iss 2, p e204 (2007)
Developmental proteins play a pivotal role in the origin of animal complexity and diversity. We report here the identification of a highly divergent developmental protein superfamily (DANGER), which originated before the emergence of animals (approxi
Externí odkaz:
https://doaj.org/article/3a3459e3ed66445d8c712947caef89cc
Autor:
Andrew J. Ewald, Feng Rao, Solomon H. Snyder, Charlotte J. Sumner, Chirag Vasavda, Neil M. Neumann, Nicholas W. Zaccor, Roxanne K. Barrow, Paul C. Scherer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(51)
Opioids are powerful analgesics, but also carry significant side effects and abuse potential. Here we describe a modulator of the μ-opioid receptor (MOR1), the transient receptor potential channel subfamily vanilloid member 1 (TRPV1). We show that T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5c77ee3d35d74da7441ff86ad6eb24
https://pubmed.ncbi.nlm.nih.gov/29203659
https://pubmed.ncbi.nlm.nih.gov/29203659
Autor:
Risheng Xu, Dorothea Fiedler, Roxanne K. Barrow, Richa Tyagi, M. Scott Vandiver, Michael A. Koldobskiy, Robert Tokhunts, James C. Barrow, Chenglai Fu, Ji-Young Cha, Solomon H. Snyder, Jing Xu, Mingxuan Wu, Feng Rao
Publikováno v:
Mol Cell
The apoptotic actions of p53 require its phosphorylation by a family of phosphoinositide-3-kinase-related-kinases (PIKKs), which include DNA-PKcs and ATM. These kinases are stabilized by the TTT (Tel2, Tti1, Tti2) co-chaperone family, whose actions a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea6a58126329046113b11551b85e817
https://doi.org/10.1016/j.molcel.2014.02.020
https://doi.org/10.1016/j.molcel.2014.02.020
Autor:
Seung Hun Cha, Roxanne K. Barrow, David Maag, Adele M. Snowman, Anutosh Chakraborty, Adam C. Resnick, Michael A. Koldobskiy, Seyun Kim, Krishna R. Juluri, Solomon H. Snyder, Sangwon F. Kim, Micah J. Maxwell
Publikováno v:
Cell Metabolism. 13:215-221
SummarymTOR complex 1 (mTORC1; mammalian target of rapamycin [mTOR] in complex with raptor) is a key regulator of protein synthesis and cell growth in response to nutrient amino acids. Here we report that inositol polyphosphate multikinase (IPMK), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8245437d191adb91773b51d38c3a603
https://doi.org/10.1016/j.cmet.2011.01.007
https://doi.org/10.1016/j.cmet.2011.01.007
Autor:
Sadia K. Gazi, Sylvain Doré, Abdullah Shafique Ahmad, Joseph T. Coyle, Jeffrey T. Ehmsen, Emil Zeynalov, Solomon H. Snyder, Gautam Sikka, Asif K. Mustafa, Roxanne K. Barrow
Publikováno v:
The Journal of Neuroscience. 30:1413-1416
d-Serine, formed froml-serine by serine racemase (SR), is a physiologic coagonist at NMDA receptors. Using mice with targeted deletion of SR, we demonstrate a role ford-serine in NMDA receptor-mediated neurotoxicity and stroke. Brain cultures of SR-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fa7b154fa2efe3c5fc35a9686be13a
https://doi.org/10.1523/jneurosci.4297-09.2010
https://doi.org/10.1523/jneurosci.4297-09.2010
Autor:
Anutosh Chakraborty, Asif K. Mustafa, Sadia K. Gazi, Jeffrey T. Ehmsen, Randen L. Patterson, Roxanne K. Barrow, L. Mario Amzel, Solomon H. Snyder, David Maag, Damian B. van Rossum
Publikováno v:
Proceedings of the National Academy of Sciences. 106:2921-2926
D-serine is a physiologic coagonist with glutamate at NMDA-subtype glutamate receptors. As D-serine is localized in glia, synaptically released glutamate presumably stimulates the glia to form and release D-serine, enabling glutamate/D-serine cotrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef7fe0b4579aaa27f11e278b4ba5413
https://doi.org/10.1073/pnas.0813105106
https://doi.org/10.1073/pnas.0813105106
Autor:
Akira Sawa, Kumiko Fujii, Asif K. Mustafa, Richard L. Huganir, Solomon H. Snyder, Takatoshi Hikida, Masoumeh Saleh, Kazuhisa Maeda, Roxanne K. Barrow, Kenji Hashimoto
Publikováno v:
Biological Psychiatry. 63:997-1000
Background d-serine is an endogenous coagonist of the N -methyl-d-aspartate subtype glutamate receptor. Genetic association studies have implicated genes coding for enzymes associated with d-serine metabolism in schizophrenia and bipolar disorder. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce63b423835b129d1773948bc80e8e8c
https://doi.org/10.1016/j.biopsych.2007.09.025
https://doi.org/10.1016/j.biopsych.2007.09.025
Autor:
Paul M. Kim, Peter S. Kim, Sasrutha R. Wickramasinghe, Amir H. Kashani, Roxanne K. Barrow, Hiroyuki Aizawa, Anirvan Ghosh, Richard L. Huganir, Solomon H. Snyder, Alex S. Huang
Publikováno v:
Proceedings of the National Academy of Sciences. 102:2105-2110
Serine racemase (SR), localized to astrocytic glia that ensheathe synapses, converts l -serine to d -serine, an endogenous ligand of the NMDA receptor. We report the activation of SR by glutamate neurotransmission involving α-amino-3-hydroxy-5-methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d523e75ce0d8bc6b3f9723610877f0
https://doi.org/10.1073/pnas.0409723102
https://doi.org/10.1073/pnas.0409723102
Publikováno v:
Proceedings of the National Academy of Sciences. 101:2328-2332
RACK1 is not a G protein but closely resembles the heterotrimeric Gβ-subunit. RACK1 serves as a scaffold, linking protein kinase C to its substrates. We demonstrate that RACK1 physiologically binds inositol 1,4,5-trisphosphate receptors and regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6039439b09b89e13601ed5f02ad04cbf
https://doi.org/10.1073/pnas.0308567100
https://doi.org/10.1073/pnas.0308567100
Autor:
Solomon H. Snyder, Christopher D. Ferris, Samie R. Jaffrey, Akira Sawa, Roxanne K. Barrow, Seth Blackshaw, Crystal C. Watkins
Publikováno v:
Journal of Clinical Investigation. 106:373-384
Gastrointestinal dysfunction is common in diabetic patients. In genetic (nonobese diabetic) and toxin-elicited (streptozotocin) models of diabetes in mice, we demonstrate defects in gastric emptying and nonadrenergic, noncholinergic relaxation of pyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80fed3c2743ab3836995cf9d6c28153
https://doi.org/10.1172/jci8273
https://doi.org/10.1172/jci8273