Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Roxanne Andaya"'
Autor:
Emily L. Meany, Roxanne Andaya, Shijia Tang, Catherine M. Kasse, Reina N. Fuji, Abigail K. Grosskopf, Andrea l. d’Aquino, Joshua T. Bartoe, Ryan Ybarra, Amy Shelton, Zachary Pederson, Chloe Hu, Dennis Leung, Karthik Nagapudi, Savita Ubhayakar, Matthew Wright, Chun-Wan Yen, Eric A. Appel
Vision impairment resulting from chronic eye diseases, such as macular degeneration and glaucoma, severely impacts patients’ quality of life and poses an immense global financial burden. Current standard of care for such diseases includes daily eye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b00bc5a4ca8b5780598d7329047fdd92
https://doi.org/10.1101/2022.09.08.507193
https://doi.org/10.1101/2022.09.08.507193
Autor:
Susan Crowell, Nardos Tassew, Roxanne Andaya, Robert F. Kelley, Mandy Kwong, Kelly M. Loyet, Steven T Laing, Aija Kusi, Yue Wang, Julia Gray, Devin Tesar
Publikováno v:
Toxicologic Pathology. 49:634-646
Fusion of biologic therapeutics to hyaluronic acid binding proteins, such as the link domain (LD) of Tumor necrosis factor (TNF)-Stimulated Gene-6 (TSG-6), is expected to increase vitreous residence time following intravitreal injection and provide f
Autor:
Denise E. de Almeida Nagata, Jennifer Vogt, Roxanne Andaya, Helen Booler, Vladimir Bantseev, Chris Schuetz, Chris Lawson, Debby P. Chang
Publikováno v:
Toxicologic Pathology. 49:621-633
Sustained drug delivery formulations are developed to reduce dose frequency while maintaining efficacy of intravitreal (ITV) administered therapeutics. Available safety data for components novel to the eye’s posterior segment may be limited, requir
Autor:
Roxanne Andaya, F. Anthony Romero, Paula Katavolos, Anand Kumar Katakam, Edna F. Choo, Gary Cain, Steven Magnuson, Jonathan Maher, Cindy Farman, Justin Ly
Publikováno v:
Toxicologic Pathology. 48:465-480
Cyclic adenosine monophosphate-response element (CREB)-binding protein (CBP) and EP300E1A-binding protein (p300) are members of the bromodomain and extraterminal motif (BET) family. These highly homologous proteins have a key role in modulating trans
Autor:
John Nicolette, Donald P. Quigley, Alejandra Trejo-Martin, David Woolley, Lidiya Stavitskaya, Lennart T. Anger, Dave Bower, Jennifer C. Sasaki, Candice Y. Johnson, Michelle O. Kenyon, Glenn J. Myatt, Sandy Weiner, Naomi L. Kruhlak, Susanne Glowienke, Véronique Gervais, Lisa Beilke, Angela White, Penny Leavitt, Roxanne Andaya, James Harvey, Joel P. Bercu, Andrew Teasdale, Jacky Van Gompel, Raymond Kemper, Kevin P. Cross, Scott Miller, Catrin Hasselgren, Barber Christopher Gordon, M. Vijayaraj Reddy, Joerg Wichard, Robert A. Jolly, Alessandro Brigo, Dennie S. Welch, Alexander Amberg, Russell Naven, Masamitsu Honma, Alexis Parenty, Stephen Gomez, Zoryanna Cammerer, Mark Powley, Laura Custer, Krista L. Dobo, Helga Gerets, Wolfgang Muster
Publikováno v:
Regulatory toxicology and pharmacology : RTP
The International Council for Harmonization (ICH) M7 guideline describes a hazard assessment process for impurities that have the potential to be present in a drug substance or drug product. In the absence of adequate experimental bacterial mutagenic
Autor:
Le An, Jonathan Maher, Yingqing Ran, Ryan E. Morgan, Lisa Wong, Laurent Salphati, Leah Schutt, Xiaolin Zhang, David Potter, Steven Cepa, Jacqueline M. Tarrant, Jodie Pang, Roxanne Andaya
Publikováno v:
Toxicology and Applied Pharmacology. 338:204-213
Drug-induced liver injury (DILI) has been the most frequent cause of post-marketing drug withdrawals in the last 50years. The multifactorial nature of events that precede severe liver injury in human patients is difficult to model in rodents due to a
Autor:
Roxanne Andaya, Kirsten Messick, Jacqueline M. Tarrant, Xiao Ding, Trung Nguyen, Jessica Couch, Michelle G. Schweiger, Shelly Zhong, Xiaorong Liang, Bianca M. Liederer, Brian Dean, Eric Harstad
Publikováno v:
ILAR Journal. 57:157-165
Improved small molecule bioanalytical sensitivity and concomitant decreased sample volume requirements provide an opportunity to reconsider how toxicokinetic (TK) data are collected in rat toxicity studies. Often, satellite groups of rats are designa
Autor:
Harstad E; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Andaya R; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Couch J; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Ding X; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Liang X; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Liederer BM; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Messick K; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Nguyen T; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Schweiger M; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Tarrant J; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Zhong S; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., Dean B; Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc.
Publikováno v:
ILAR journal [ILAR J] 2016 Dec; Vol. 57 (2), pp. 157-165.