Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Roxane Paulin"'
Autor:
Naomie Jutras-Beaudoin, BSc, Victoria Toro, MSc, Annie Christine Lajoie, MD, Sandra Breuils-Bonnet, MSc, Roxane Paulin, PhD, François Potus, PhD
Publikováno v:
CJC Open, Vol 4, Iss 4, Pp 357-363 (2022)
Background: The blood neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a powerful predictor of adverse outcomes in some cardiovascular and lung diseases. Pulmonary arterial hypertension (PAH) is a lethal vasculopathy associated with incre
Externí odkaz:
https://doaj.org/article/00c4f875c51f44cfb5f13afcb6c53fb1
Autor:
Yann Grobs, Charifa Awada, Sarah-Eve Lemay, Charlotte Romanet, Alice Bourgeois, Victoria Toro, Valérie Nadeau, Kana Shimauchi, Mark Orcholski, Sandra Breuils-Bonnet, Eve Tremblay, Steeve Provencher, Roxane Paulin, Olivier Boucherat, Sébastien Bonnet
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2919 (2021)
Trifluoperazine (TFP), an antipsychotic drug approved by the Food and Drug Administration, has been show to exhibit anti-cancer effects. Pulmonary arterial hypertension (PAH) is a devastating disease characterized by a progressive obliteration of sma
Externí odkaz:
https://doaj.org/article/a773316ffc034a4791b9796d7d8f9482
Autor:
Karima Habbout, Junichi Omura, Charifa Awada, Alice Bourgeois, Yann Grobs, Vinod Krishna, Sandra Breuils-Bonnet, Eve Tremblay, Ghada Mkannez, Sandra Martineau, Valérie Nadeau, Florence Roux-Dalvai, Mark Orcholski, Jey Jeyaseelan, David Gutstein, François Potus, Steeve Provencher, Sébastien Bonnet, Roxane Paulin, Olivier Boucherat
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2957 (2021)
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by a sustained elevation of pulmonary artery (PA) pressure, right ventricular failure, and premature death. Enhanced proliferation and resistance to apoptosis (as seen in c
Externí odkaz:
https://doaj.org/article/cf1ef3e146fd42f8b2577f234c9e0913
Autor:
Olivier Boucherat, Sophie Chabot, Roxane Paulin, Isabelle Trinh, Alice Bourgeois, François Potus, Marie-Claude Lampron, Caroline Lambert, Sandra Breuils-Bonnet, Valérie Nadeau, Renée Paradis, Elena A. Goncharova, Steeve Provencher, Sébastien Bonnet
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with limited therapeutic options. Although exposed to stressful conditions, pulmonary artery (PA) smooth muscle cells (PASMCs) exhibit a “cancer-like” pro-proliferati
Externí odkaz:
https://doaj.org/article/f90d5634c64f49ecb27fef8c14550b2f
Autor:
Valerie Nadeau, Francois Potus, Olivier Boucherat, Renee Paradis, Eve Tremblay, Marc Iglarz, Roxane Paulin, Sebastien Bonnet, Steeve Provencher
Publikováno v:
Pulmonary Circulation, Vol 8 (2017)
Dysregulated metabolism and rarefaction of the capillary network play a critical role in pulmonary arterial hypertension (PAH) etiology. They are associated with a decrease in perfusion of the lungs, skeletal muscles, and right ventricle (RV). Previo
Externí odkaz:
https://doaj.org/article/b57f2dfda196438098e8d4844c8e62ea
Autor:
Natasha Fillmore, Alda Huqi, Jagdip S Jaswal, Jun Mori, Roxane Paulin, Alois Haromy, Arzu Onay-Besikci, Lavinia Ionescu, Bernard Thébaud, Evangelos Michelakis, Gary D Lopaschuk
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120257 (2015)
Successful stem cell therapy requires the optimal proliferation, engraftment, and differentiation of stem cells into the desired cell lineage of tissues. However, stem cell therapy clinical trials to date have had limited success, suggesting that a b
Externí odkaz:
https://doaj.org/article/43eb18d4498d43a1ac10fdbbd2c9fb57
Autor:
Benoît Ranchoux, Jolyane Meloche, Roxane Paulin, Olivier Boucherat, Steeve Provencher, Sébastien Bonnet
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 6, p 990 (2016)
Pulmonary hypertension (PH) is defined by a mean pulmonary arterial pressure over 25 mmHg at rest and is diagnosed by right heart catheterization. Among the different groups of PH, pulmonary arterial hypertension (PAH) is characterized by a progressi
Externí odkaz:
https://doaj.org/article/a6b09e6c4c4d4539ad1443045da7680d
Autor:
Tsukasa Shimauchi, Olivier Boucherat, Tetsuro Yokokawa, Yann Grobs, WenHui Wu, Mark Orcholski, Sandra Martineau, Junichi Omura, Eve Tremblay, Kana Shimauchi, Valérie Nadeau, Sandra Breuils-Bonnet, Roxane Paulin, François Potus, Steeve Provencher, Sébastien Bonnet
Publikováno v:
JACC: Basic to Translational Science. 7:384-403
The authors show that increased poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) and pyruvate kinase muscle isozyme 2 (PKM2) expression is a common feature of a decompensated right ventricle in patients with pulmonary arterial hypertension and
Autor:
Annie C. Lajoie, Sandra Breuils-Bonnet, François Potus, Naomie Jutras-Beaudoin, Roxane Paulin, Victoria Toro
Publikováno v:
CJC Open. 4:357-363
The blood neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a powerful predictor of adverse outcomes in some cardiovascular and lung diseases. Pulmonary arterial hypertension (PAH) is a lethal vasculopathy associated with increased inflamm
Autor:
Junichi Omura, Sandra Breuils-Bonnet, Eve Tremblay, Alice Bourgeois, Steeve Provencher, Yann Grobs, Tsukasa Shimauchi, Geraldine Vitry, Wen-Hui Wu, Victoria Toro, Mark Orcholski, Roxane Paulin, Sandra Martineau, Valérie Nadeau, Sébastien Bonnet, Pasquale Ferraro, Charlotte Romanet, François Potus, Olivier Boucherat
Publikováno v:
Thorax. 77:247-258
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterised by exuberant tissue remodelling and associated with high unmet medical needs. Outcomes are even worse when IPF results in secondary pulmonary hypertension (PH). Imp