Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Roxane Desjardins"'
Autor:
Nawel Mekdad, Thi Minh Hue Tran, Roxane Desjardins, Anna Kwiatkowska, Frédéric Couture, Robert Day
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Prostate cancer (PCa) is a complex disease progressing from in situ to invasive or metastatic tumors while also being capable of modulating its androgen dependence. Understanding how novel therapies are working across the different stages of
Externí odkaz:
https://doaj.org/article/1a20c45ac946450584feee92fb579f6d
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 11, Pp 1032-1042 (2012)
Better understanding of the distinct and redundant functions of the proprotein convertase (PC) enzyme family within pathophysiological states has a great importance for potential therapeutic strategies. In this study, we investigated the functional r
Externí odkaz:
https://doaj.org/article/3fe40c5d3fc1461a94c0fa671e5cbfd9
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61557 (2013)
The proprotein convertase 1/3 (PC1/3) is an important post-translational processing enzyme for the activation of precursor proteins within the regulated secretory pathway. Well characterized for its role in the neural and endocrine systems, we recent
Externí odkaz:
https://doaj.org/article/716b168afcf24c2eaa0c720118ccba8a
Autor:
Katarzyna Gawlik, Sergey A Shiryaev, Wenhong Zhu, Khatereh Motamedchaboki, Roxane Desjardins, Robert Day, Albert G Remacle, Boguslaw Stec, Alex Y Strongin
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5031 (2009)
Before furin can act on protein substrates, it must go through an ordered process of activation. Similar to many other proteinases, furin is synthesized as a zymogen (profurin) which becomes active only after the autocatalytic removal of its auto-inh
Externí odkaz:
https://doaj.org/article/d2db3482d0ba40c39fe0eefd5a615202
Autor:
Robert Day, Luigi Bouchard, Simon-Pierre Guay, Roxane Desjardins, Anna Kwiatkowska, Robert Sabbagh, Frédéric Couture
Supplementary material and methods relating to cell culture, cell treatments and transfections, proliferation assays, Western blot analysis etc. and Supplementary Figure Legends for Supplementary Figures 1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6508114888dbd654f01cc6b764ce5ae5
https://doi.org/10.1158/0008-5472.22416437.v1
https://doi.org/10.1158/0008-5472.22416437.v1
Autor:
Robert Day, Luigi Bouchard, Simon-Pierre Guay, Roxane Desjardins, Anna Kwiatkowska, Robert Sabbagh, Frédéric Couture
PACE4 mRNA splicing analysis and primer design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089e9639c45da5b205a3ae2783beb725
https://doi.org/10.1158/0008-5472.22416458.v1
https://doi.org/10.1158/0008-5472.22416458.v1
Autor:
Robert Day, Luigi Bouchard, Simon-Pierre Guay, Roxane Desjardins, Anna Kwiatkowska, Robert Sabbagh, Frédéric Couture
SILAC secretome data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9cb3eebdd63667cd9e391a9032c9dd
https://doi.org/10.1158/0008-5472.22416425.v1
https://doi.org/10.1158/0008-5472.22416425.v1
Autor:
Robert Day, Luigi Bouchard, Simon-Pierre Guay, Roxane Desjardins, Anna Kwiatkowska, Robert Sabbagh, Frédéric Couture
Primer sequences and antibodies specifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c46af7b13c880fbbe7e9ca2b70429d7
https://doi.org/10.1158/0008-5472.22416434
https://doi.org/10.1158/0008-5472.22416434
Autor:
Robert Day, Luigi Bouchard, Simon-Pierre Guay, Roxane Desjardins, Anna Kwiatkowska, Robert Sabbagh, Frédéric Couture
Inhibition of PACE4, a proprotein convertase that is overexpressed in prostate cancer, has been shown to block cancer progression in an androgen-independent manner. However, the basis for its overexpression and its growth-inhibitory effects are mitig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f42a6f1ff2fb9bbbc8104adf36e4e1
https://doi.org/10.1158/0008-5472.c.6509549
https://doi.org/10.1158/0008-5472.c.6509549
Autor:
Robert Day, Luigi Bouchard, Simon-Pierre Guay, Roxane Desjardins, Anna Kwiatkowska, Robert Sabbagh, Frédéric Couture
Supplementary data and material regarding the alternative splicing detailed analysis by PCR and IHC, decitabine efficacy, supplementary cell line testing by overexpression and silencing and substrate screening by western blots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5792c6e4efc4837a7b919c14eaa338
https://doi.org/10.1158/0008-5472.22416440
https://doi.org/10.1158/0008-5472.22416440