Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori.

Autor: Andreea Sodolescu, Cyril Dian, Laurent Terradot, Latifa Bouzhir-Sima, Roxane Lestini, Hannu Myllykallio, Stéphane Skouloubris, Ursula Liebl

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0208850 (2018)

Serine hydroxymethyltransferase (SHMT), encoded by the glyA gene, is a ubiquitous pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the formation of glycine from serine. The thereby generated 5,10-methylene tetrahydrofolate (MTHF) is a maj

Externí odkaz: https://doaj.org/article/948ddc00bab64642a468e1771d278205

Differential interaction kinetics of a bipolar structure-specific endonuclease with DNA flaps revealed by single-molecule imaging.

Autor: Rachid Rezgui, Roxane Lestini, Joëlle Kühn, Xenia Fave, Lauren McLeod, Hannu Myllykallio, Antigoni Alexandrou, Cedric Bouzigues

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e113493 (2014)

As DNA repair enzymes are essential for preserving genome integrity, understanding their substrate interaction dynamics and the regulation of their catalytic mechanisms is crucial. Using single-molecule imaging, we investigated the association and di

Externí odkaz: https://doaj.org/article/1fc2067025194cf398af77df1499cc42

Methylselenol Produced In Vivo from Methylseleninic Acid or Dimethyl Diselenide Induces Toxic Protein Aggregation in Saccharomyces cerevisiae

Autor: Ryszard Lobinski, Marc Dauplais, Myriam Lazard, Katarzyna Bierla, Coralie Maizeray, Pierre Plateau, Roxane Lestini, Joanna Szpunar

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (5), pp.1-21. ⟨10.3390/ijms22052241⟩
International Journal of Molecular Sciences, 2021, 22 (5), pp.2241. ⟨10.3390/ijms22052241⟩
Volume 22
Issue 5
International Journal of Molecular Sciences, MDPI, 2021, 22 (5), pp.2241. ⟨10.3390/ijms22052241⟩
International Journal of Molecular Sciences, Vol 22, Iss 2241, p 2241 (2021)

Methylselenol (MeSeH) has been suggested to be a critical metabolite for anticancer activity of selenium, although the mechanisms underlying its activity remain to be fully established. The aim of this study was to identify metabolic pathways of MeSe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df4ab82e67adcd3ed5aca6b135d7c72
https://hal-univ-pau.archives-ouvertes.fr/hal-03162634/file/ijms-22-02241-v2-1.pdf

Snapshots of archaeal DNA replication and repair in living cells using super-resolution imaging

Autor: Hannu Myllykallio, Emmanuel Beaurepaire, Roxane Lestini, Yoann Collien, Pierre Mahou, Floriane Delpech

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2018, ⟨10.1093/nar/gky829⟩
Nucleic Acids Research, 2018, ⟨10.1093/nar/gky829⟩

Using the haloarchaeon Haloferax volcanii as a model, we developed nascent DNA labeling and the functional GFP-labeled single-stranded binding protein RPA2 as novel tools to gain new insight into DNA replication and repair in live haloarchaeal cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f4ccb05ea2cd72a682ce4ad4cb962f
https://doi.org/10.1093/nar/gky829

Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes

Autor: Nhan, van Tran, Leslie, Muller, Robert L, Ross, Roxane, Lestini, Juliette, Létoquart, Nathalie, Ulryck, Patrick A, Limbach, Valérie, de Crécy-Lagard, Sarah, Cianférani, Marc, Graille

Publikováno v: Nucleic acids research. 46(16)

Protein synthesis is a complex and highly coordinated process requiring many different protein factors as well as various types of nucleic acids. All translation machinery components require multiple maturation events to be functional. These include

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6deb253f4aaf216f719272ee5d89bd2
https://pubmed.ncbi.nlm.nih.gov/30010922