Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Roxana-Maria Rujan"'
Autor:
Phil Pickford, Maria Lucey, Roxana-Maria Rujan, Emma Rose McGlone, Stavroula Bitsi, Fiona B. Ashford, Ivan R. Corrêa, David J. Hodson, Alejandra Tomas, Giuseppe Deganutti, Christopher A. Reynolds, Bryn M. Owen, Tricia M. Tan, James Minnion, Ben Jones, Stephen R. Bloom
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101242- (2021)
Objective: Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating t
Externí odkaz:
https://doaj.org/article/81eb48b9c1554fad855b7b0e36385ffc
Autor:
Giuseppe Deganutti, Silvia Atanasio, Roxana-Maria Rujan, Patrick M. Sexton, Denise Wootten, Christopher A. Reynolds
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones. An unders
Externí odkaz:
https://doaj.org/article/d348c6f0e82d477487b7b314deab29b4
Autor:
Sara M. Willems, Josée Dupuis, Martina Müller-Nurasyid, Boehnke M, Mark H, Salem, Inês Barroso, Letizia Marullo, Kari Stefansson, C Gieger, Anna Ulrich, Morris J. Brown, González Ksg, Grant W. Montgomery, Anders Hamsten, Emma Ahlqvist, Aaron Isaacs, Kay-Tee Khaw, Amy Hofman, Corrêa Ir, Inger Njølstad, L Zudina, Rona J. Strawbridge, J. Tuomilehto, E Albrecht, Jing Hua Zhao, Patrick M. Sexton, Mark I. McCarthy, Roxana Maria Rujan, Chiara Scapoli, Anne U. Jackson, Ioanna Tzoulaki, van Duijn C, Giuseppe Deganutti, Reedik Mägi, Jose C. Florez, Bernhard O. Boehm, Toby Johnson, Petar Todorov, Jones B, Inga Prokopenko, Leif Groop, Lagou, Hugh Watkins, Balkhiyarova Z, Tomas A, Longda Jiang, Oddgeir L. Holmen, Tan Tm, Barbara Thorand, Andre G. Uitterlinden, Wolfgang Koenig, He Gao, Sodbo Zh Sharapov, Claudia Langenberg, D Rybin, Ayse Demirkan, H Grallert, Christine Meisinger, Eric F, Denise Wootten, Heinz Erich Wichmann, Wolfgang Kratzer, Paul Elliott, Tune H. Pers, Beben Benyamin, Yurii S. Aulchenko, Robert A. Scott, Marika Kaakinen, Alessia David, Tom Wilsgaard, John Whitfield, Patricia B. Munroe, Chen S, Karen L. Mohlke, Alessia Faggian, Evangelos Evangelou, Philippe Froguel, Nicholas J. Wareham, Unnur Thorsteinsdottir, N. G. Martin, Christopher A. Reynolds, Steinthorsdottir, Heather M. Stringham, Mark J. Caulfield, Gudmar Thorleifsson, James B. Meigs, Anuj Goel, Kristian Hveem, Evan L. Brittain, Julian S
Homeostatic control of blood glucose requires different physiological responses in the fasting and post-prandial states. We reasoned that glucose measurements under non-standardised conditions (random glucose; RG) may capture diverse glucoregulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e4d80872e2445f49e7123f3fd68633
https://doi.org/10.1101/2021.04.17.21255471
https://doi.org/10.1101/2021.04.17.21255471
Autor:
Stavroula Bitsi, Roxana-Maria Rujan, Stephen R. Bloom, Giuseppe Deganutti, Ben Jones, Ivan R. Corrêa, Phil Pickford, James Minnion, Fiona B. Ashford, Emma Rose McGlone, Bryn M. Owen, Alejandra Tomas, David J. Hodson, Tricia Tan, Christopher A. Reynolds, Maria Lucey
ObjectiveGlucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study we investigated the cellular and metabolic effects of modulating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59a70cb7d87a7f1ed3ed02cb09c1f0a4
https://doi.org/10.1101/2021.03.02.433157
https://doi.org/10.1101/2021.03.02.433157
Autor:
Nicole Prodan, Michael P. Hay, Keith Richards, Roxana Maria Rujan, Rebekah L. Bower, Debbie L. Hay, Augen A. Pioszak, Risha Sudra, Erica R. Hendrikse, Muhammad A. Jamaluddin, Christopher S. Walker, Muriel Bonnet, Jack U. Flanagan, Lydia P. Liew, David M. Smith, Garry Pairaudeau, Jason M. Booe, Christopher A. Reynolds
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Class B G protein-coupled receptors are highly therapeutically relevant but challenges remain in identifying suitable small-molecule drugs. The calcitonin-like receptor (CLR) in particular is linked to conditions such as migraine, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cad1eccc07505f73ff6ab7e3e92e43f
https://europepmc.org/articles/PMC7155196/
https://europepmc.org/articles/PMC7155196/
Autor:
Maria Lucey, Stavroula Bitsi, Alejandra Tomas, David J. Hodson, Roxana-Maria Rujan, Ivan R. Corrêa, Giuseppe Deganutti, Christopher A. Reynolds, Fiona B. Ashford, Emma Rose McGlone, Stephen R. Bloom, Phil Pickford, Tricia Tan, James Minnion, Ben Jones, Bryn M. Owen
Publikováno v:
Molecular Metabolism, Vol 51, Iss, Pp 101242-(2021)
Molecular Metabolism
Molecular Metabolism
Objective Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating th
Publikováno v:
Handbook of experimental pharmacology. 255
The calcitonin gene-related peptide (CGRP) receptor is composed of the calcitonin receptor-like receptor (CLR, a class B GPCR) and a single-pass membrane protein known as receptor activity modifying protein type 1 (RAMP1). The levels of the CGRP pept
Publikováno v:
Calcitonin Gene-Related Peptide (CGRP) Mechanisms ISBN: 9783030214531
The calcitonin gene-related peptide (CGRP) receptor is composed of the calcitonin receptor-like receptor (CLR, a class B GPCR) and a single-pass membrane protein known as receptor activity modifying protein type 1 (RAMP1). The levels of the CGRP pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4a1a844ae50db538b16dfbbf768c660
https://doi.org/10.1007/164_2018_173
https://doi.org/10.1007/164_2018_173