Výsledky vyhledávání - "Roxana-Irina Albu"

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Publikováno v: Blood, Vol. 133, no. 25, p. 2669-2681 (2019)

Calreticulin (CALR) +1 frameshift mutations in exon 9 are prevalent in myeloproliferative neoplasms. Mutant CALRs possess a new C-terminal sequence rich in positively charged amino acids, leading to activation of the thrombopoietin receptor (TpoR/MPL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc4fb014fde76029beb226ff051d945
https://pubmed.ncbi.nlm.nih.gov/31221790

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Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants

Autor: Gaëlle Vertenoeil, Roxana-Irina Albu, Jean-Philippe Defour, Vitalina Gryshkova, Hana Raslova, Caroline Marty, Meng Ling Choong, Isabelle Plo, Robert Kralovics, Mira El-Khoury, Ann Koay, Anna Ngo, Christian Pecquet, Ilyas Chachoua, Pierre J. Courtoy, William Vainchenker, Harini Nivarthi, Stefan N. Constantinescu

Publikováno v: Blood, Vol. 127, no. 10, p. 1325-35 (2016)

Mutations in the calreticulin gene (CALR) represented by deletions and insertions in exon 9 inducing a -1/+2 frameshift are associated with a significant fraction of myeloproliferative neoplasms (MPNs). The mechanisms by which CALR mutants induce MPN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49c2466e7fcf26e8a82d1e81f78f4ca
https://hdl.handle.net/2078.1/168151

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An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L

Autor: Siham Boukour, Hana Raslova, Leila N. Varghese, Rémi Favier, Christian Pecquet, Vitalina Gryshkova, Fabrizia Favale, Najet Debili, William Vainchenker, Roxana-Irina Albu, Paola Ballerini, Kahia Messaoudi, Isabelle Plo, Stefan N. Constantinescu, Guy Leverger, Jean-Philippe Defour, Olivier Bluteau

Publikováno v: Blood, Vol. 128, no. 26, p. 3146-3158 (2016)

The mechanisms behind the hereditary thrombocytosis induced by the thrombopoietin (THPO) receptor MPL P106L mutant remain unknown. A complete trafficking defect to the cell surface has been reported, suggesting either weak constitutive activity or no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8031c5ccce6f1cb9f5574744d51862
https://hdl.handle.net/2078.1/180993

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The mechanisms of activation of the single chain cytokine receptors: preformed and ligand-induced dimerization

Autor: Roxana Irina Albu, Vitalina Gryshkova, S.N. Constatinescu

Publikováno v: Biopolymers and Cell, Vol 30, Iss 3, Pp 184-189 (2014)

Despite intensive studies, the mechanisms of cytokine receptor activation are still not completely understood. Historically two models have been proposed: early studies suggested a mechanism involving ligand-induced di- merization of the receptors wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d284d9cf24e0d6b58112e0d5457c9bd
http://dspace.nbuv.gov.ua/handle/123456789/154300

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Extracellular Domain N-Glycosylation Controls Human Thrombopoietin Receptor Cell Surface Levels

Autor: Stefan N. Constantinescu, Roxana Irina Albu

Publikováno v: Frontiers in Endocrinology, Vol 2 (2011)
Frontiers in Endocrinology, Vol. 2, no.0, p. 71 (2011)
Frontiers in Endocrinology

The thrombopoietin receptor (TpoR) is a type I transmembrane protein that mediates the signaling functions of thrombopoietin (Tpo) in regulating megakaryocyte differentiation, platelet formation, and hematopoietic stem cell renewal. We probed the rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a7b46c6d9a8c2bf645e9340101771d
http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00071/full

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Multiple oligomerization domains of KANK1-PDGFRβ are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK

Autor: Sandrine Medves, Laura A. Noël, Hélène Schoemans, Carmen P. Montano-Almendras, Roxana-Irina Albu, Stefan N. Constantinescu, Jean-Baptiste Demoulin

KANK1-PDGFRB is a fusion gene generated by the t(5;9) translocation between KANK1 and the platelet-derived growth factor receptor beta gene PDGFRB. This hybrid was identified in a myeloproliferative neoplasm featuring severe thrombocythemia, in the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b42e8952cefb5fc3ddf100ce7f61391
https://europepmc.org/articles/PMC3186300/

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