Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Roxana Ola"'
Autor:
Kuheli Banerjee, Yanzhu Lin, Johannes Gahn, Julio Cordero, Purnima Gupta, Islam Mohamed, Mariona Graupera, Gergana Dobreva, Martin A. Schwartz, Roxana Ola
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Vascular networks form, remodel, and mature under the influence of both fluid shear stress (FSS) and soluble factors. Physiological FSS promotes and maintains vascular stability via synergy with bone morphogenic proteins 9 and 10 (BMP9 and BMP10). Co
Externí odkaz:
https://doaj.org/article/b542650ec401437cb3c92d2af512b770
Autor:
Natali Froese, Julio Cordero, Aya Abouissa, Felix A. Trogisch, Steve Grein, Malgorzata Szaroszyk, Yong Wang, Anna Gigina, Mortimer Korf-Klingebiel, Berislav Bosnjak, Colin F. Davenport, Lutz Wiehlmann, Robert Geffers, Eva Riechert, Lonny Jürgensen, Etienne Boileau, Yanzhu Lin, Christoph Dieterich, Reinhold Förster, Johann Bauersachs, Roxana Ola, Gergana Dobreva, Mirko Völkers, Joerg Heineke
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103965- (2022)
Summary: To identify cellular mechanisms responsible for pressure overload triggered heart failure, we isolated cardiomyocytes, endothelial cells, and fibroblasts as most abundant cell types from mouse hearts in the subacute and chronic stages after
Externí odkaz:
https://doaj.org/article/6224cc5550424983837de122401cc858
Autor:
Gael Genet, Kevin Boyé, Thomas Mathivet, Roxana Ola, Feng Zhang, Alexandre Dubrac, Jinyu Li, Nafiisha Genet, Luiz Henrique Geraldo, Lorena Benedetti, Steffen Künzel, Laurence Pibouin-Fragner, Jean-Leon Thomas, Anne Eichmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.
Externí odkaz:
https://doaj.org/article/a65242a5aee94d9999a57269b93f9bd4
Autor:
Jan R. Kraehling, John H. Chidlow, Chitra Rajagopal, Michael G. Sugiyama, Joseph W. Fowler, Monica Y. Lee, Xinbo Zhang, Cristina M. Ramírez, Eon Joo Park, Bo Tao, Keyang Chen, Leena Kuruvilla, Bruno Larriveé, Ewa Folta-Stogniew, Roxana Ola, Noemi Rotllan, Wenping Zhou, Michael W. Nagle, Joachim Herz, Kevin Jon Williams, Anne Eichmann, Warren L. Lee, Carlos Fernández-Hernando, William C. Sessa
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Atherosclerosis is caused by low-density lipoprotein (LDL) buildup in the vessel wall, a process thought to be mediated by LDL receptor alone. Here, the authors show that the endothelium can uptake LDL via ALK1, a TGFβ signalling receptor, suggestin
Externí odkaz:
https://doaj.org/article/745c383654124c2b97ea3d105429cf8d
Autor:
Roxana Ola, Alexandre Dubrac, Jinah Han, Feng Zhang, Jennifer S. Fang, Bruno Larrivée, Monica Lee, Ana A. Urarte, Jan R. Kraehling, Gael Genet, Karen K. Hirschi, William C. Sessa, Francesc V. Canals, Mariona Graupera, Minhong Yan, Lawrence H. Young, Paul S. Oh, Anne Eichmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Arteriovenous malformations (AVM) is a hallmark of hereditary haemorrhagic telangiectasia type 2, a disease caused by mutations in BMP receptor ALK1. Ola et al. show that AVM can be caused by blocking BMP9 and BMP10 in mice, leading to increased VEGF
Externí odkaz:
https://doaj.org/article/7b411bab54424730b576b6b6c001bd4f
Autor:
Vitor Fortuna, Luc Pardanaud, Isabelle Brunet, Roxana Ola, Emma Ristori, Massimo M. Santoro, Stefania Nicoli, Anne Eichmann
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1786-1796 (2015)
The sympathetic nervous system controls smooth muscle tone and heart rate in the cardiovascular system. Postganglionic sympathetic neurons (SNs) develop in close proximity to the dorsal aorta (DA) and innervate visceral smooth muscle targets. Here, w
Externí odkaz:
https://doaj.org/article/e766c9dd225247fc86f7a7bf2e5525bf
Autor:
Anmol Kumar, Jaakko Kopra, Kärt Varendi, Lauriina L Porokuokka, Anne Panhelainen, Satu Kuure, Pepin Marshall, Nina Karalija, Mari-Anne Härma, Carolina Vilenius, Kersti Lilleväli, Triin Tekko, Jelena Mijatovic, Nita Pulkkinen, Madis Jakobson, Maili Jakobson, Roxana Ola, Erik Palm, Maria Lindahl, Ingrid Strömberg, Vootele Võikar, T Petteri Piepponen, Mart Saarma, Jaan-Olle Andressoo
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005808 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1005710.].
Externí odkaz:
https://doaj.org/article/758f22d521a842cdbb2b4a44423a1884
Autor:
Anmol Kumar, Jaakko Kopra, Kärt Varendi, Lauriina L Porokuokka, Anne Panhelainen, Satu Kuure, Pepin Marshall, Nina Karalija, Mari-Anne Härma, Carolina Vilenius, Kersti Lilleväli, Triin Tekko, Jelena Mijatovic, Nita Pulkkinen, Madis Jakobson, Maili Jakobson, Roxana Ola, Erik Palm, Maria Lindahl, Ingrid Strömberg, Vootele Võikar, T Petteri Piepponen, Mart Saarma, Jaan-Olle Andressoo
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005710 (2015)
Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has
Externí odkaz:
https://doaj.org/article/97fe460db77842808cd04bfe6e27a58c
Autor:
Raili Koivuniemi, Johanna Mäkelä, Marie-Estelle Hokkanen, Céline Bruelle, Tho Huu Ho, Roxana Ola, Laura Korhonen, Jim Schröder, Hiroaki Kataoka, Dan Lindholm
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56117 (2013)
BACKGROUND: Neural progenitor cells (NPCs) in the developing neuroepithelium are regulated by intrinsic and extrinsic factors. There is evidence that NPCs form a self-supporting niche for cell maintenance and proliferation. However, molecular interac
Externí odkaz:
https://doaj.org/article/30deb7ac8b3e42df8b5c5295af7267f7
Autor:
Linda Kessler, Rui Gao, Nalan Tetik-Elsherbiny, Olga Lityagina, Azhar Zhailauova, Yonggang Ren, Felix A. Trogisch, Julio Cordero, Yanliang Dou, Yinuo Wang, Evgeny Chichelnitskiy, Joscha Alexander Kraske, Patricia Laura Schäfer, Chi-Chung Wu, Guillermo Barreto, Michael Potente, Thomas Wieland, Roxana Ola, Joerg Heineke, Gergana Dobreva
SummaryDuring embryogenesis, distinct cardiac cell types form, which shape the structural and functional properties of the heart. How their activity is coordinated is largely unknown. Here we show that Rnf20 is a multifaceted regulator of cardiac mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78bbdc7923cb36fe8a3a715995f874ca
https://doi.org/10.1101/2022.09.16.508288
https://doi.org/10.1101/2022.09.16.508288