Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors

Autor: Monica-Cornelia Sardaru, Anda Mihaela Craciun, Cristina-Maria Al Matarneh, Isabela Andreea Sandu, Roxana Maria Amarandi, Lacramioara Popovici, Catalina Ionica Ciobanu, Dragos Peptanariu, Mariana Pinteala, Ionel I. Mangalagiu, Ramona Danac

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1581-1595 (2020)

A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhi

Externí odkaz: https://doaj.org/article/991624767b6e4e398dd822986eb52e4d

Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives

Autor: Lacramioara Popovici, Roxana-Maria Amarandi, Ionel I. Mangalagiu, Violeta Mangalagiu, Ramona Danac

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 230-243 (2019)

Two new series of heterocyclic derivatives with potential anticancer activity, in which a pyrrolo[1,2-b]pyridazine or a pyrrolo[2,1-a]phthalazine moiety was introduced in place of the 3′-hydroxy-4′-methoxyphenyl ring of phenstatin have been synth

Externí odkaz: https://doaj.org/article/c739272a2f444748bd38a64ffaef8fd8

Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors

Autor: Catalina Ionica Ciobanu, Ionel I. Mangalagiu, Lacramioara Popovici, Monica-Cornelia Sardaru, Ramona Danac, Mariana Pinteala, Dragos Peptanariu, Anda Mihaela Craciun, Isabela Andreea Sandu, Cristina-Maria Al Matarneh, Roxana Maria Amarandi

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1581-1595 (2020)

A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b833b8ad50cd6f730714b31d63c534
https://doi.org/10.1080/14756366.2020.1801671

Pyrrolo-fused heterocyclic derivatives: design, synthesis and anticancer evaluation

Autor: Roxana-Maria Amarandi, Maria-Cristina Al-Matarneh, Lacramioara Popovici, Ionel Mangalagiu, Vasilichia Bejan, Catalina-Ionica Ciobanu, Ramona Danac

Publikováno v: New frontiers in natural product chemistry: A destiny on the altar of research: Dedicated to academician Pavel Vlad.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddd850ffabd60483f0b1fa9df71833fb
https://doi.org/10.19261/nfnpc.2021.ab17

Design, Synthesis, Molecular Modelling and Anticancer Activities of New Fused Phenanthrolines

Autor: Gheorghita Zbancioc, Anda Mihaela Craciun, Cristina M. Al Matarneh, Ionel I. Mangalagiu, Ramona Danac, Roxana Maria Amarandi

Publikováno v: Molecules, Vol 25, Iss 3, p 527 (2020)
Molecules
Volume 25
Issue 3

Three series of fused pyrrolophenanthroline derivatives were designed as analogues of phenstatin and synthesized in two steps starting with 1,7-phenanthroline, 4,7-phenanthroline and 1,10-phenanthroline, respectively. Two (Compounds 8a and 11c) of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a586da66f79ed821f58d6a5da44fa8e1
https://www.mdpi.com/1420-3049/25/3/527