Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Roxana Atanasiu"'
Autor:
Brian Foo, William C. Valinsky, Tsukasa Okiyoneda, Pirjo M. Apaja, Roxana Atanasiu, Gergely L. Lukacs, Herve Barriere, Eckhard Ficker, Alvin Shrier
Publikováno v:
Molecular Biology of the Cell
The role of the plasma membrane quality control machinery is demonstrated in the development of the long QT syndrome phenotype, caused by acquired and inherited conformational defects of the hERG potassium channel in multiple expression systems, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35fa336a3a240f960d8b09cb1a0b501b
https://doi.org/10.1091/mbc.e13-07-0417
https://doi.org/10.1091/mbc.e13-07-0417
Autor:
Valerie E. Walker, Christine Hantouche, Alvin Shrier, Roxana Atanasiu, Michael J.H. Wong, Jason C. Young
Publikováno v:
Journal of Biological Chemistry. 285:3319-3329
Loss of function mutations in the hERG (human ether-a-go-go related gene or KCNH2) potassium channel underlie the proarrhythmic cardiac long QT syndrome type 2. Most often this is a consequence of defective trafficking of hERG mutants to the cell sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606745c3c9e104b10bba3b5bb2881cb9
https://doi.org/10.1074/jbc.m109.024000
https://doi.org/10.1074/jbc.m109.024000
Publikováno v:
Journal of Biological Chemistry. 282:23509-23516
The Long QT Syndrome is a cardiac disorder associated with ventricular arrhythmias that can lead to syncope and sudden death. One prominent form of the Long QT syndrome has been linked to mutations in the HERG gene (KCNH2) that encodes the voltage-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c7e9e3fcf6141f3d356bb45a34a5cd
https://doi.org/10.1074/jbc.m701006200
https://doi.org/10.1074/jbc.m701006200
Publikováno v:
The Journal of Physiology. 515:41-48
1. Long QT syndrome (LQT) is an electrophysiological disorder that can lead to sudden death from cardiac arrhythmias. One form of LQT has been attributed to mutations in the human ether-a-go-go-related gene (HERG) that encodes a voltage-gated cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af633c1744cb5fa8ea34c9153500fa8
https://doi.org/10.1111/j.1469-7793.1999.041ad.x
https://doi.org/10.1111/j.1469-7793.1999.041ad.x
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 276:H709-H717
The Na+/H+exchanger NHE1 isoform is an integral component of cardiac intracellular pH homeostasis that is critically important for myocardial contractility. To gain further insight into its physiological significance, we determined its cellular distr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c0e57e3a59b8ad8f6ff4cf0a2eea34
https://doi.org/10.1152/ajpheart.1999.276.2.h709
https://doi.org/10.1152/ajpheart.1999.276.2.h709
The interaction of cationic nanoparticles with mouse capillary endothelial cells in situ and in vivo
Autor:
Aurelian Radu, Roxana Atanasiu
Publikováno v:
International Journal of Pharmaceutics. 90:119-128
We addressed the question of whether cationic nanoparticles of 50–300 nm diameter could cross the vascular capillary endothelium in a process similar to clearing transcytosis. This problem presents interest in the field of drug targeting by panicul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc307782e79a73bed73ebda796b5edd3
https://doi.org/10.1016/0378-5173(93)90148-9
https://doi.org/10.1016/0378-5173(93)90148-9
Publikováno v:
Journal of cell science. 118(Pt 13)
Mutations of a putative cyclic-nucleotide-binding domain (CNBD) can disrupt the function of the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN2) and the human ether-a-go-go-related gene potassium channel (HERG). Loss of function cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e708170b3eef4fd012803a9f0265c71
https://pubmed.ncbi.nlm.nih.gov/15961404
https://pubmed.ncbi.nlm.nih.gov/15961404
Publikováno v:
The Journal of biological chemistry. 278(41)
Mutations in the potassium channel encoded by the human ether-a-go-go-related gene (HERG) have been linked to the congenital long QT syndrome (LQTS), a cardiac disease associated with an increased preponderance of ventricular arrhythmias and sudden d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a036dff8519b29bcf199ebe96bc592
https://pubmed.ncbi.nlm.nih.gov/12885765
https://pubmed.ncbi.nlm.nih.gov/12885765
Autor:
Alvin Shrier, Pirjo M. Apaja, Tsukasa Okiyondea, Eckhard Ficker, Roxana Atanasiu, Gergely L. Lukacs, Hung Lam, Brian Foo, Herve Barriere
Publikováno v:
Biophysical Journal. 102:677a
The KCNH2 or human ether-a-go-go related gene (HERG1) encodes the Kv11.1 protein that is responsible for the rapidly activating delayed rectifier K+ current (IKr). Mutations of HERG cause prolongation of cardiac ventricular repolarzation that underli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033966af5e2a4850cb5e8cb03b0826ef
https://doi.org/10.1016/j.bpj.2011.11.3683
https://doi.org/10.1016/j.bpj.2011.11.3683
Autor:
Herve Barriere, Tsukasa Okiyoneda, Gergely L. Lukacs, Roxana Atanasiu, Alvin Shrier, Hung D. Lam
Publikováno v:
Biophysical Journal. (3):331a
Long QT syndrome (LQTS) is a cardiac disorder that is characterized by a prolonged QT interval on the electrocardiogram, syncope and in severe cases sudden death. LQTS type 2 is associated with loss-of-function mutations in the human-ether-a-go-go-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afe137ba77994a8c2aba052e4722cdb