Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

Autor: Smith, Michael P., Brunton, Holly, Rowling, Emily J., Ferguson, Jennifer, Arozarena, Imanol, Miskolczi, Zsofia, Lee, Jessica L., Girotti, Maria R., Marais, Richard, Levesque, Mitchell P., Dummer, Reinhard, Frederick, Dennie T., Flaherty, Keith T., Cooper, Zachary A., Wargo, Jennifer A., Wellbrock, Claudia

Publikováno v: In Cancer Cell 14 March 2016 29(3):270-284

Detection of apoptosis by PET/CT with the diethyl ester of [18F]ML-10 and fluorescence imaging with a dansyl analogue

Autor: Kadirvel, Manikandan, Fairclough, Michael, Cawthorne, Christopher, Rowling, Emily J., Babur, Muhammad, McMahon, Adam, Birkket, Paul, Smigova, Alison, Freeman, Sally, Williams, Kaye J., Brown, Gavin

Publikováno v: In Bioorganic & Medicinal Chemistry 1 January 2014 22(1):341-349

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

Autor: Smith, Michael P, Rowling, Emily J, Miskolczi, Zsofia, Ferguson, Jennifer, Spoerri, Loredana, Haass, Nikolas K, Sloss, Olivia, McEntegart, Sophie, Arozarena, Imanol, von Kriegsheim, Alex, Rodriguez, Javier, Brunton, Holly, Kmarashev, Jivko, Levesque, Mitchell P, Dummer, Reinhard, Frederick, Dennie T, Andrews, Miles C, Cooper, Zachary A, Flaherty, Keith T, Wargo, Jennifer A, Wellbrock, Claudia

Publikováno v: Smith, M, Rowling, E, Miskolczi, Z, Ferguson, J, Spoerri, L, Haass, N K, Sloss, O, McEntegart, S, Arozarena, I, Kriegsheim, A V, Rodriguez, J, Brunton, H, Kmarashev, J, Levesque, M P, Dummer, R, Frederick, D T, Flaherty, K T, Andrews, M, Cooper, Z A, Wargo, J A & Wellbrock, C 2017, ' Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure ', EMBO Molecular Medicine . https://doi.org/10.15252/emmm.201607156
EMBO Molecular Medicine
Smith, M P, Rowling, E J, Miskolczi, Z, Ferguson, J, Spoerri, L, Haass, N K, Sloss, O, McEntegart, S, Arozarena, I, von Kriegsheim, A, Rodriguez, J, Brunton, H, Kmarashev, J, Levesque, M P, Dummer, R, Frederick, D T, Andrews, M C, Cooper, Z A, Flaherty, K T, Wargo, J A & Wellbrock, C 2017, ' Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure ', EMBO Molecular Medicine . https://doi.org/10.15252/emmm.201607156

Approaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a "MITF-high" phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also contain subpopulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8cdcf444aebcef9c5474956100dbcf15
https://doi.org/10.15252/emmm.201607156

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

Autor: Young, Helen L., Rowling, Emily J., Bugatti, Mattia, Giurisato, Emanuele, Luheshi, Nadia, Arozarena, Imanol, Acosta, Juan-Carlos, Kamarashev, Jivko, Frederick, Dennie T., Cooper, Zachary A., Reuben, Alexandre, Gil, Jesus, Flaherty, Keith T., Wargo, Jennifer A., Vermi, William, Smith, Michael P., Wellbrock, Claudia, Hurlstone, Adam

Publikováno v: The Journal of Experimental Medicine
Young, H, Rowling, E, Bugatti, M, Giurisato, E, Luheshi, N, Arozarena, I, Acosta, J-C, Kamarashev, J, Frederick, D T, Cooper, Z A, Reuben, A, Gil, J, Flaherty, K T, Wargo, J A, Vermi, W, Smith, M, Wellbrock, C & Hurlstone, A 2017, ' An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition ', Journal of Experimental Medicine, vol. 214, no. 5 . https://doi.org/10.1084/jem.20160855
Young, H L, Rowling, E J, Bugatti, M, Giurisato, E, Luheshi, N, Arozarena, I, Acosta, J-C, Kamarashev, J, Frederick, D T, Cooper, Z A, Reuben, A, Gil, J, Flaherty, K T, Wargo, J A, Vermi, W, Smith, M P, Wellbrock, C & Hurlstone, A 2017, ' An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition ', Journal of Experimental Medicine, vol. 214, no. 6, pp. 1691–1710 . https://doi.org/10.1084/jem.20160855

Drug tolerance brought about by reversible adaptive responses precedes the emergence of irreversible mutation-driven drug resistance and sustains tumor cells when at their most vulnerable. Young et al. delineate a signaling relay incorporating IL-1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d689dd9b848bbf1ca933f242401a0bf2
http://hdl.handle.net/11379/493847

A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF^high/AXL^low melanoma.

Autor: Smith, Michael P., Rana, Sareena, Ferguson, Jennifer, Rowling, Emily J., Flaherty, Keith T., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia

Publikováno v: Pigment Cell & Melanoma Research; Mar2019, Vol. 32 Issue 2, p280-291, 12p