Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format

Autor: Hussain, K, Hargreaves, CE, Rowley, TF, Sopp, JM, Latham, KV, Bhatta, P, Sherington, J, Cutler, RM, Humphreys, DP, Glennie, MJ, Strefford, JC, Cragg, MS

Publikováno v: Frontiers in Immunology

Monoclonal antibody (mAb) immunotherapy has transformed the treatment of allergy, autoimmunity, and cancer. The interaction of mAb with Fc gamma receptors (FcγR) is often critical for efficacy. The genes encoding the low-affinity FcγR have single n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1b7e94b222d525446333af6493afa377
http://europepmc.org/articles/PMC6417454

Stellabody: A novel hexamer-promoting mutation for improved IgG potency.

Autor: Whitehead CA; Immune Therapies Group, Burnet Institute, Melbourne, Victoria, Australia.; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Wines BD; Immune Therapies Group, Burnet Institute, Melbourne, Victoria, Australia.; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Davies AM; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London, UK., McDonnell JM; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London, UK., Trist HM; Immune Therapies Group, Burnet Institute, Melbourne, Victoria, Australia., Esparon SE; Immune Therapies Group, Burnet Institute, Melbourne, Victoria, Australia., Hogarth PM; Immune Therapies Group, Burnet Institute, Melbourne, Victoria, Australia.; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.

Publikováno v: Immunological reviews [Immunol Rev] 2024 Nov; Vol. 328 (1), pp. 438-455. Date of Electronic Publication: 2024 Oct 04.

Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions.

Autor: Qureshi OS; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Rowley TF; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Junker F; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Peters SJ; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Crilly S; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Compson J; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Eddleston A; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Björkelund H; Ridgeview Diagnostics AB, Uppsala Science Park, SE75183, Uppsala, Sweden., Greenslade K; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Parkinson M; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Davies NL; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Griffin R; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Pither TL; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Cain K; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Christodoulou L; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Staelens L; UCB Biopharma Sprl., Chemin du Foriest, Braine l'Alleud, Belgium., Ward E; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Tibbitts J; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Kiessling A; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Smith B; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Brennan FR; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Malmqvist M; Ridgeview Diagnostics AB, Uppsala Science Park, SE75183, Uppsala, Sweden., Fallah-Arani F; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK., Humphreys DP; UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK. david.humphreys@ucb.com.

Publikováno v: Scientific reports [Sci Rep] 2017 Dec 06; Vol. 7 (1), pp. 17049. Date of Electronic Publication: 2017 Dec 06.

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CD27 costimulation contributes substantially to the expansion of functional memory CD8(+) T cells after peptide immunization.

Autor: Taraban VY; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK., Rowley TF, Kerr JP, Willoughby JE, Johnson PM, Al-Shamkhani A, Buchan SL

Publikováno v: European journal of immunology [Eur J Immunol] 2013 Dec; Vol. 43 (12), pp. 3314-23. Date of Electronic Publication: 2013 Oct 01.