Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease

Autor: Rasneer S. Bains, Hamish Forrest, Rowland R. Sillito, J. Douglas Armstrong, Michelle Stewart, Patrick M. Nolan, Sara E. Wells

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 17 (2023)

Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. Video-tracking, in particular, lends itself to automated machine-learning technologies that have

Externí odkaz: https://doaj.org/article/28abc31ac6754ee3a87926b410363df9

Temporal dissociation of phencyclidine-induced locomotor and social alterations in rats using an automated homecage monitoring system - implications for the 3Rs and preclinical drug discovery

Autor: Judith A. Pratt, Emma J. Mitchell, Ros R. Brett, J. Douglas Armstrong, Rowland R. Sillito

Publikováno v: Mitchell, E J, Brett, R R, Armstrong, J D, Sillito, R R & Pratt, J A 2020, ' Temporal dissociation of phencyclidine: Induced locomotor and social alterations in rats using an automated homecage monitoring system – implications for the 3Rs and preclinical drug discovery ', Journal of Psychopharmacology, vol. 34, no. 7, pp. 709-715 . https://doi.org/10.1177/0269881120920455
Journal of Psychopharmacology (Oxford, England)

Background: Rodent behavioural assays are widely used to delineate the mechanisms of psychiatric disorders and predict the efficacy of drug candidates. Conventional behavioural paradigms are restricted to short time windows and involve transferring a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d141f66c95b49b81debc348bf31d6237
https://strathprints.strath.ac.uk/72343/1/Mitchell_etal_JP_2020_Temporal_dissociation_of_phencyclidine_induced_locomotor_and_social_alterations.pdf

Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools

Autor: Patrick M. Nolan, Heather Cater, J. Douglas Armstrong, Rowland R. Sillito, Rasneer Sonia Bains, Sara Wells, Gareth Banks

Publikováno v: Journal of Neuroscience Methods
Bains, R S, Sillito, R R, Armstrong, J D, Cater, H L, Banks, G & Nolan, P M 2017, ' Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools ', Journal of Neuroscience Methods . https://doi.org/10.1016/j.jneumeth.2017.04.014

Highlights • Automated assessment of mouse home-cage behaviour is robust and reliable. • Analysis over multiple light/dark cycles improves ability to classify behaviours. • Combined RFID and video analysis enables home-cage analysis in group ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cd31404e3f3a079171911203bf74aa
https://doi.org/10.1016/j.jneumeth.2017.04.014

Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project

Autor: J. Douglas Armstrong, Kathryn Chapman, Lauren Leslie, William S. Redfern, Rowland R. Sillito, Karen K Tse, Amy Keerie, Catherine Vickers, Claire Grant, Natasha A. Karp, J. A. Heward, John C. Pedersen, Agis Chartsias, Victoria Rimmer, David J. Simpson, T.C. Lukins, Stephanie Klein

Publikováno v: Redfern, W S, Tse, K, Grant, C, Keerie, A, Simpson, D J, Pedersen, J C, Rimmer, V, Leslie, L, Klein, S K, Karp, N A, Sillito, R, Chartsias, A, Lukins, T, Heward, J, Vickers, C, Chapman, K, Armstrong, J D & Homberg, J (ed.) 2017, ' Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project ', PLoS ONE, vol. 12, no. 9, e0181068, pp. 1-26 . https://doi.org/10.1371/journal.pone.0181068
PLoS ONE, Vol 12, Iss 9, p e0181068 (2017)
PLoS ONE

Measuring the activity and temperature of rats is commonly required in biomedical research. Conventional approaches necessitate single housing, which affects their behavior and wellbeing. We have used a subcutaneous radiofrequency identification (RFI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d03a5c66a06d7c3d71cca296a3d2625
https://www.pure.ed.ac.uk/ws/files/43688572/journal.pone.0181068_1_.pdf

Rodent Big Brother: Automated Video Recognition of Home Cage Behaviours in Safety Pharmacology and Toxicology Studies in Group-Housed Rates

Autor: David J. Simpson, Amy Keerie, Rowland R. Sillito, Agisilaos Chartsias, Will S. Redfern, J. Douglas Armstrong, Catherine Vickers, Kathryn Chapman, Karen Tse, Lauren Leslie, Claire Grant, Victoria Rimmer

Publikováno v: Journal of Pharmacological and Toxicological Methods. 88:194-195

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09f6242a2ef4b39622fdc53a262dfb90
https://doi.org/10.1016/j.vascn.2017.09.086