Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rowena Sison-Young"'
Autor:
Serat-E Ali, James C Waddington, Adam Lister, Rowena Sison-Young, Robert P Jones, Adeeb H Rehman, Chris E P Goldring, Dean J Naisbitt, Xiaoli Meng
Publikováno v:
Toxicological Sciences. 192:106-116
Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver injury. Although expression of HLA-B*57:01 is associated with increased susceptibility, little is known of the pathological mechanisms involved in the ind
Autor:
Amy Schofield, Philip J. Starkey Lewis, Rhona Aird, Ian M. Copple, Fang Zhang, B. Kevin Park, Christopher E. Goldring, Tobias M Bunday, Stephen W. Fenwick, Yongxiang Fang, Shiva S. Forootan, Harish Poptani, Mohamed Elmasry, Emanuele Ricci, Hassan Malik, Jack Sharkey, Neil R. Kitteringham, Giusy Russomanno, Timothy Andrews, Nathalie Brillant, Benjamin K Y Chan, Adam Lister, Stuart J. Forbes, Rowena Sison-Young
Publikováno v:
Hepatology. 74:973-986
Background and aims The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates an array of cytoprotective genes, yet studies in transgenic mice have led to conflicting reports on its role in liver regeneration. We aimed to
Autor:
Giusy Russomanno, Rowena Sison-Young, Lucia A. Livoti, Hannah Coghlan, Rosalind E. Jenkins, Steven J. Kunnen, Ciarán P. Fisher, Dennis Reddyhoff, Iain Gardner, Adeeb H. Rehman, Stephen W. Fenwick, Andrew R. Jones, Guy Vermeil De Conchard, Gilles Simonin, Helene Bertheux, Richard J. Weaver, Michael J. Liguori, Diana Clausznitzer, James L. Stevens, Christopher E. Goldring, Ian M. Copple
To minimise unexpected toxicities in early phase clinical studies of new drugs, it is vital to understand fundamental similarities and differences between preclinical test species and humans. We have used physiologically-based pharmacokinetic modelli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::681d5b219b7f1f608f9ac0467a0f6f7c
https://doi.org/10.1101/2022.04.13.488145
https://doi.org/10.1101/2022.04.13.488145
Autor:
Rowena Sison-Young, Min Wei Wong, Chris S. Pridgeon, Michael J. Cross, Christopher E. Goldring, John Greenman, James E. Sidaway, Vitalina Gryshkova, Joseph Leedale, Paul Walker, Tahera Ansari, Emma L. Wilkinson, Laurence Launay, Susan Gibbs, B. Kevin Park, Tobias Heckel, Stefan Przyborski, R. N. Bearon, Constanze Schlott, Minne B. Heringa, Delilah F. G. Hendriks
Publikováno v:
Pridgeon, C S, Schlott, C, Wong, M W, Heringa, M B, Heckel, T, Leedale, J, Launay, L, Gryshkova, V, Przyborski, S, Bearon, R N, Wilkinson, E L, Ansari, T, Greenman, J, Hendriks, D F G, Gibbs, S, Sidaway, J, Sison-Young, R L, Walker, P, Cross, M J, Park, B K & Goldring, C E P 2018, ' Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms ', Archives of Toxicology, vol. 92, no. 2, pp. 557-569 . https://doi.org/10.1007/s00204-018-2152-9
Archives of Toxicology
Archives of Toxicology
The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new products safely to market in a cost-effective and timely manner. In addition, improvement
Autor:
James A. Heslop, Stephen W. Fenwick, Richard Kia, B. Kevin Park, John S. Mills, Triantafillos Liloglou, Christopher S. Pridgeon, Rowena Sison-Young, Christopher E. Goldring, Neil R. Kitteringham, Mohamed Elmasry
Publikováno v:
Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 6, Iss 8, Pp 1751-1751 (2017)
Stem Cells Translational Medicine, Vol 6, Iss 8, Pp 1751-1751 (2017)
Drug-induced liver injury is the greatest cause of post-marketing drug withdrawal; therefore, substantial resources are directed toward triaging potentially dangerous new compounds at all stages of drug development. One of the major factors preventin
Autor:
B. Kevin Park, Catherine C. Bell, Tommy B. Andersson, Sabine U. Vorrink, Sabrina M. L. Moro, Ewa Ellis, Inger Johansson, Christopher E. Goldring, Souren Mkrtchian, Delilah F. G. Hendriks, Magnus Ingelman-Sundberg, Fatemah Rezayee, Rowena Sison-Young, Volker M. Lauschke, Åsa Nordling
Publikováno v:
Hepatology. 64:1743-1756
Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo. However, in two-dimensional cultures, primary human hepatocytes (PHHs) rapidly dedifferentiate, resul
Autor:
Mohamed Elmasry, Cerys A. Lovatt, Julie C. Holder, Christopher E. Goldring, Hélène Aerts, Christopher A. Schofield, Helga H.J. Gerets, Delphine Hoët, Richard J. Weaver, Eliane Alexandre, Lysiane Richert, Gilles Labbe, Esther Johann, Sébastien Anthérieu, Martina Dorau, Magnus Ingelman-Sundberg, B. Kevin Park, Neil R. Kitteringham, Robert P. Jones, Simone H. Stahl, Philip G. Hewitt, Rowena Sison-Young, Volker M. Lauschke
Publikováno v:
Archives of Toxicology
Assessing the potential of a new drug to cause drug-induced liver injury (DILI) is a challenge for the pharmaceutical industry. We therefore determined whether cell models currently used in safety assessment (HepG2, HepaRG, Upcyte and primary human h
Autor:
Steffen Rädisch, Hassan Malik, David Dickens, Munir Pirmohamed, Rowena Sison-Young, George N. Chiduza, Emma L. Wilkinson, Elke Schaeffeler, Anne T. Nies, Christopher E. Goldring, Athina Giannoudis, Matthias Schwab, Michael J. Cross
Publikováno v:
Molecular Pharmaceutics
The weak base antipsychotic clozapine is the most effective medication for treating refractory schizophrenia. The brain-to-plasma concentration of unbound clozapine is greater than unity, indicating transporter-mediated uptake, which has been insuffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c737906d9da54cf63c9a9eb9104a52e3
Autor:
Fang Zhang, Sebastian Malkusch, Mike Heilemann, Lea Zimmermann, Franziska Herrmann, Christopher E. Goldring, B. Kevin Park, Robert P. Jones, Angela Oppelt, Daniel Kaschek, Suzanna Huppelschoten, Hassan Malik, Carmen L. Krüger, Benjamin Merkt, Jens Timmer, Ursula Klingmüller, Mara Meub, Amy Schofield, Rowena Sison-Young, Marie Buck-Wiese, Bob van de Water, Marcel Schilling
Publikováno v:
npj Systems Biology and Applications
NPJ Systems Biology and Applications
npj Systems Biology and Applications, 4, 23
npj Systems Biology and Applications, Vol 4, Iss 1, Pp 1-16 (2018)
NPJ Systems Biology and Applications
npj Systems Biology and Applications, 4, 23
npj Systems Biology and Applications, Vol 4, Iss 1, Pp 1-16 (2018)
Drug-induced liver injury (DILI) has become a major problem for patients and for clinicians, academics and the pharmaceutical industry. To date, existing hepatotoxicity test systems are only poorly predictive and the underlying mechanisms are still u
Autor:
Sarah A, Smith, Helen E, Colley, Parveen, Sharma, Klaudia M, Slowik, Rowena, Sison-Young, Andrew, Sneddon, Steven D, Webb, Craig, Murdoch
Publikováno v:
Experimental dermatology. 27(5)
CYP3A4 and CYP4A5 share specificity for a wide range of xenobiotics with the CYP3 subfamily collectively involved in the biotransformation of approximately 30% of all drugs. CYP3A4/5 mRNA transcripts have been reported in the skin, yet knowledge of t