Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rowena Sharpe"'
Autor:
Amit Patel, Gerard Thompson, Joshua Savage, Rhys Mant, Colin Watts, Olaf Ansorge, Victoria Wykes, Helen Bulbeck, Lucinda Billingham, Adam D Waldman, Rowena Sharpe, Ute Pohl, John Apps
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Introduction Gliomas are the most common primary tumour of the central nervous system (CNS), with an estimated annual incidence of 6.6 per 100 000 individuals in the USA and around 14 deaths per day from brain tumours in the UK. The genomic and biolo
Externí odkaz:
https://doaj.org/article/4f97b946e2c5402daeff2a9291573e31
Autor:
Dhruv Parekh, Simon Gates, Julian Bion, Tonny Veenith, Matthew Rowland, Tony Whitehouse, Anna Rowe, Pamela Kearns, Benjamin A. Fisher, Daniel Slade, Rowena Sharpe, David R. Thickett, James Scriven, Sarah J. Bowden, Joshua S. Savage, Duncan Richards
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
Introduction Severe SARS-CoV-2 infection is associated with a dysregulated immune response. Inflammatory monocytes and macrophages are crucial, promoting injurious, proinflammatory sequelae. Immunomodulation is, therefore, an attractive therapeutic s
Externí odkaz:
https://doaj.org/article/876bb3a7415440ab913c4a3d0ca09a2c
Autor:
Colin Watts, Joshua Savage, Amit Patel, Rhys Mant, Victoria Wykes, Ute Pohl, Helen Bulbeck, John Apps, Rowena Sharpe, Gerard Thompson, Adam D Waldman, Olaf Ansorge, Lucinda Billingham
Publikováno v:
2022, ' Protocol for the Tessa Jowell BRAIN MATRIX Platform Study ', BMJ Open, vol. 12, no. 9, pp. e067123 . https://doi.org/10.1136/bmjopen-2022-067123
IntroductionGliomas are the most common primary tumour of the central nervous system (CNS), with an estimated annual incidence of 6.6 per 100 000 individuals in the USA and around 14 deaths per day from brain tumours in the UK. The genomic and biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a7a83a26aedab34971db7983c798b1
https://www.pure.ed.ac.uk/ws/files/312743827/e067123.full.pdf
https://www.pure.ed.ac.uk/ws/files/312743827/e067123.full.pdf
Autor:
Benjamin A Fisher, Tonny Veenith, Daniel Slade, Charlotte Gaskell, Matthew Rowland, Tony Whitehouse, James Scriven, Dhruv Parekh, Madhu S Balasubramaniam, Graham Cooke, Nick Morley, Zoe Gabriel, Matthew P Wise, Joanna Porter, Helen McShane, Ling-Pei Ho, Philip N Newsome, Anna Rowe, Rowena Sharpe, David R Thickett, Julian Bion, Simon Gates, Duncan Richards, Pamela Kearns, Bryan Williams, Rebecca Turner, Vincenzo Libri, Francis Mussai, Gary Middleton, Sarah Bowden, Mansoor Bangash, Fang Gao-Smith, Jaimin Patel, Elizabeth Sapey, Mark Thomas, Mark Coles, Peter Watkinson, Naj Rahman, Brian Angus, Alexander J. Mentzer, Alex Novak, Marc Feldman, Alex Richter, Sian Faustini, Camilla Bathurst, Joseph Van de Wiel, Susie Mee, Karen James, Bushra Rahman, Karen Turner, Adam Hill, Anthony Gordon, Christina Yap, Michael Matthay, Danny McAuley, Andrew Hall, Paul Dark, Andrew McMichael
Publikováno v:
investigators, CATALYST & Dark, P 2022, ' Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial. ', The Lancet. Respiratory medicine, vol. 10, no. 3, pp. 255-266 . https://doi.org/10.1016/S2213-2600(21)00460-4
The Lancet. Respiratory Medicine
The Lancet. Respiratory Medicine
Background: Dysregulated inflammation is associated with poor outcomes in COVID-19. We aimed to assess the efficacy of namilumab (a granulocyte-macrophage colony stimulating factor inhibitor) and infliximab (a tumour necrosis factor inhibitor) in hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad54ed5704be7627c0e7cae395cc8c01
https://www.research.manchester.ac.uk/portal/en/publications/namilumab-or-infliximab-compared-with-standard-of-care-in-hospitalised-patients-with-covid19-catalyst-a-randomised-multicentre-multiarm-multistage-openlabel-adaptive-phase-2-proofofconcept-trial(df3f7821-b379-4211-8ca4-7e23572680d1).html
https://www.research.manchester.ac.uk/portal/en/publications/namilumab-or-infliximab-compared-with-standard-of-care-in-hospitalised-patients-with-covid19-catalyst-a-randomised-multicentre-multiarm-multistage-openlabel-adaptive-phase-2-proofofconcept-trial(df3f7821-b379-4211-8ca4-7e23572680d1).html
Autor:
Matthew J. Rowland, Pamela Kearns, Daniel Slade, Simon Gates, Sarah Bowden, Anna Rowe, Tonny Veenith, Joshua Savage, David R Thickett, Dhruv Parekh, Duncan Richards, James Scriven, Julian Bion, Rowena Sharpe, Tony Whitehouse, Benjamin A Fisher
Publikováno v:
BMJ Open
BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open, Vol 11, Iss 11 (2021)
Introduction Severe SARS-CoV-2 infection is associated with a dysregulated immune response. Inflammatory monocytes and macrophages are crucial, promoting injurious, proinflammatory sequelae. Immunomodulation is, therefore, an attractive therapeutic s
Autor:
Tonny Veenith, Anna Rowe, Madhu S. Balasubramaniam, Duncan Richards, Matthew J. Rowland, Benjamin A Fisher, Tony Whitehouse, Rowena Sharpe, Joanna C. Porter, Daniel Slade, Matt P. Wise, Philip N. Newsome, Dhruv Parekh, James Scriven, Julian Bion, Nick Morley, David R Thickett, Ling-Pei Ho, Charlotte Gaskell, Zoe Gabriel, Graham S Cooke, Pamela Kearns, Simon Gates, Helen McShane
SummaryBackgroundDysregulated inflammation is associated with poor outcomes in Coronavirus disease 2019 (COVID-19). We assessed the efficacy of namilumab, a granulocyte-macrophage colony-stimulating factor inhibitor and infliximab, a tumour necrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0b16cbdb2f4a0246214263eb2a9897e
https://doi.org/10.1101/2021.06.02.21258204
https://doi.org/10.1101/2021.06.02.21258204
Autor:
Sarah Bowden, Pamela Kearns, Dhruv Parekh, Simon Gates, Matthew J. Rowland, James Scriven, David R Thickett, Anna Rowe, Benjamin A Fisher, Daniel Slade, Tonny Veenith, Joshua Savage, Duncan Richards, Rowena Sharpe, Julian Bion, Tony Whitehouse
IntroductionSevere SARS-CoV-2 infection is associated with a dysregulated immune response. Inflammatory monocytes and macrophages are crucial, promoting injurious, pro-inflammatory sequelae. Immunomodulation is, therefore, an attractive therapeutic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c62c4917bee6f32d496601cc676cee18
https://doi.org/10.1101/2021.02.10.21251478
https://doi.org/10.1101/2021.02.10.21251478
Autor:
Martin Forster, Joshua Savage, Dee Wherton, Yvonne Summers, Emilia L. Lim, P. Jain, James Spicer, Noelle O'Rourke, Alison Brewster, Thomas B.K. Watkins, Peter Fletcher, Tara C. Mills, Charles Swanton, David Gilligan, Sanjay Popat, Melanie Mackean, Maria Antonietta Cerone, Alastair Greystoke, Judith Cave, Lucinda Billingham, Manita Mehmi, Rowena Sharpe, Elizabeth Toy, Gary Middleton, Amanda Farley, Adam Dangoor, Timothy A. Yap
Publikováno v:
Nature
The majority of targeted therapies for non-small-cell lung cancer (NSCLC) are directed against oncogenic drivers that are more prevalent in patients with light exposure to tobacco smoke1–3. As this group represents around 20% of all patients with l
Autor:
Colin R. Lindsay, Emily C. Shaw, Fiona Blackhall, Kevin G. Blyth, James D. Brenton, Anshuman Chaturvedi, Noel Clarke, Craig Dick, Thomas R.J. Evans, Geoff Hall, Andrew M. Hanby, David J. Harrison, Stephen R.D. Johnston, Malcolm D. Mason, Dion Morton, Julia Newton-Bishop, Andrew G. Nicholson, Karin A. Oien, Sanjay Popat, Doris Rassl, Rowena Sharpe, Phillipe Taniere, Ian Walker, William A. Wallace, Nicholas P. West, Rachel Butler, David Gonzalez de Castro, Mike Griffiths, Peter W.M. Johnson, Pauline Rehal, Samantha Butler, Matthew Smith, Rachel Doak, Anna Tanska, Graham Halford, Lisa James, Chris Kotara, Gareth Masson, Sam Clokie, Jennie Bell, Fiona Macdonald, David Gonzalez De Castro, Lisa Thompson, Debbie Mair, Suzanne Lillis, Dorte Wren, Robert Hollifield, Keeda Dover, Manisha Maurya, Damian Brooks, Belen Gomez, Lisa Grady, Thomas Jones, Chantal Hooper, Daphne Webster, Jolyon Travis, Stephanie Ogwuru, Jana Gazdova, Denise Collins, Elaine Chapman, Lisa Leavey, Paula Proszek, Sanna Hulkki, V.Peter Collins, Ash Ibrahim, Kat Brown, Jo Burge, Karen Burnett, Ginny Devonshire, Ellen Moseley, Bev Haynes, Charlotte Hodgkin, Merche Jimenez-linan, Linda Jones, Gilly Kenyon, Betania Mahler-araujo, Karen Payne, Jo Piper, Sue Richardson, Ed Rytina, Anne Warren, Liz Coker, Gemma Godsall, Mark Arends, Amanda O’Neill, Katy Rintoul, Donna Goymer, Julie Taylor, Claire Matthews, Harshil Bhayani, Tina Osalador, Zakiya Niwaz, Anna Higgins, Olivia Bamsey, Janine Salter, Louise Renouf, Glenn Noel-Storr, Helen Roberts, Kasia Gierejko, Paola Knapman, Andrew Wotherspoon, Gordon Stamp, Ayoma Attygailye, Steve Hazell, Peter Osin, Ash Nerurkar, Steven Francis, Marion Runde, Jo Arch, Xavier Chitnis, Bernard Siu, Debra Townsend, Laura Hennelly, Natalie Taylor, Bernadette Johnson, Susie Banerjee, Lynda Pyle, Monica Hamill, Jenny Gyertson, Angela George, Krishna Patel, Karla Pearce, Kim Edmonds, Sarah Sarker, Rosalind Eeles, Liz Bancroft, Sarah Thomas, Yukie Kano, Lisa Rowland, Karen Brooks, Mary O’brien, Jaishree Bhosle, Kathy Priest, Bee Ayite, Jo Severn, Helen Beedham, Nicky Lucas, Kim Tye, Alison Lorentzos, Janine Webb, Sarah Kerr, Lisa Corestav, Diego Bottero, Laura Jell, Janet Thomas, Cheryl Marriott, Neil Rajah, Andy Cole, Dieu Ly, Philippe Taniere, Brendan O’sullivan, Clare Swift, Frances Hughes, Desley Neil, Andrew Hanby, Roz Banks, Dolapo Ajayi, Alison Barclay, Julia Newton Bishop, Debbie Beirne, Andrew Bernard, Maxine Berry, Jo Bentley, Tim Bishop, Amy Chambers, Jude Clarke, Anne Crossley, Narinder Gahir, Debbie Gibson, Rona Good, Konstantina Grosios, Pat Harnden, Kate Hasler, Damien Hindmarch, Sharon Jackson, Colin Johnstone, Anne-marie Jones, Gil Lambert, Sally Lane, Nicola Mcnicholas, Rebecca Millican-Slater, Cath Moriaty, Alex Newsham, Kara O’connell, Lisa Ripley, David Sebag-Montefiore, Mary Simpson, Val Speirs, Joh Sugden, Lauren Tate, Emma Tidswell, Chris Twelves, Christy Walker, Barry Waterhouse, Martin Waugh, Louise White, Elizabeth Wright, Jane Rogan, Garry Ashton, Caron Abbey, Michelle Greenhalgh, Daisuke Nonaka, Elwyn Shing, Carmen Gibbard, Georgina Burton, Naomi Fawkes, Angela Marsden, Rachael Waddington, Phil Harrison, Shahrzad Moghadam, Kate Murray, Sarah Brown, Christy Mitchinson, Richard Booton, Rajesh Shah, David Harrison, Anca Oniscu, William Wallace, Frances Rae, Craig Marshall, Linda Mcleod, Morag Charles, Sarah Jane Sutherland, Carol Dawson, Paul Mitchell, Alex Maclellan, Sandra Muir, Lynne Johnstone, John O’connor, Shirley Johnstone, Jim Mcpherson, Jane Hair, Massimo Pignatelli, Roma Armstrong, Karin Oien, Jeff Evans, Margaret Burgoyne, Karen Blessing, Fraser Duthie, Colin Moyes, Elizabeth Mallon, David Millan, Fiona Roberts, Morag Seywright, Siobhan Fraser, Ian Ford, Sharon Kean, Marion Flood, David Grant, Claire Mcdonald, Tom Moffat, Hugh Mclelland, Alistair Kyle, Graham Cameron, Martin Wright, Stephen Kenny, Karen Mcauslan, Andrew Jones, Ted Fitzsimons, Fiona Graham, Alexandra Bell, Phil Duffy, Alec Fisher, Alexis Smith, Elaine Shannon, Bryan Woods, Colin Hutchison, Angela Booth, Lyndsay Duffy, Gillian Mcculloch, Hudda Sadiq, Susan Deakin, Steven Haywood, Malcolm Mason, John Chester, Alison Parry-jones, Abby Macarthur, Suzanne Williams, David Griffiths, Fiona Morgan, Hazel Bailey
Publikováno v:
Lindsay, C, Shaw, E, Blackhall, F, Blyth, K, Brenton, J D, Chaturvedi, A, Clarke, N, Dick, C, Evans, T R J, Hall, G, Hanby, A M, Harrison, D J, Johnston, S, Mason, M D, Morton, D, Newton-Bishop, J, Nicholson, A G, Oien, K A, Popat, S, Rassl, D, Sharpe, R, Taniere, P, Walker, I, Wallace, W A, West, N P, Butler, R, Gonzales de Castro, D, Griffiths, M & Johnson, P W M 2018, ' Somatic cancer genetics in the UK : Real-world data from phase i of the Cancer Research UK Stratified Medicine Programme ', ESMO Open, vol. 3, no. 6, e000408 . https://doi.org/10.1136/esmoopen-2018-000408
Lindsay, C R, Shaw, E, Blackhall, F, Blyth, K G, Brenton, J D, Chaturvedi, A, Clarke, N W, Dick, C, Evans, T RJ, Hall, G, Hanby, A M, Harrison, D, Johnston, S, Mason, M D, Morton, D, Newton-Bishop, J, Nicholson, A G, Oien, K A, Popat, S, Rassl, D M, Sharpe, R, Taniere, P, Walker, I, Wallace, W, West, N P, Butler, R, Gonzales de Castro, D, Griffiths, M & Johnson, P WM 2018, ' Somatic Cancer Genetics in the UK: Real-World Data from Phase One of the Cancer Research UK Stratified Medicine Programme ', ESMO Open . https://doi.org/10.1136/esmoopen-2018-000408
Lindsay, C R, Shaw, E C, Blackhall, F, Blyth, K G, Brenton, J D, Chaturvedi, A, Clarke, N, Dick, C, Evans, T R J, Hall, G, Hanby, A M, Harrison, D J, Johnston, S R D, Mason, M D, Morton, D, Newton-Bishop, J, Nicholson, A G, Oien, K A, Popat, S, Rassl, D, Sharpe, R, Taniere, P, Walker, I, Wallace, W A, West, N P, Butler, R, Gonzalez de Castro, D, Griffiths, M & Johnson, P W M 2018, ' Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme ', ESMO Open, vol. 3, no. 6, e000408 . https://doi.org/10.1136/esmoopen-2018-000408
Lindsay, C R, Shaw, E, Blackhall, F, Blyth, K G, Brenton, J D, Chaturvedi, A, Clarke, N W, Dick, C, Evans, T RJ, Hall, G, Hanby, A M, Harrison, D, Johnston, S, Mason, M D, Morton, D, Newton-Bishop, J, Nicholson, A G, Oien, K A, Popat, S, Rassl, D M, Sharpe, R, Taniere, P, Walker, I, Wallace, W, West, N P, Butler, R, Gonzales de Castro, D, Griffiths, M & Johnson, P WM 2018, ' Somatic Cancer Genetics in the UK: Real-World Data from Phase One of the Cancer Research UK Stratified Medicine Programme ', ESMO Open . https://doi.org/10.1136/esmoopen-2018-000408
Lindsay, C R, Shaw, E C, Blackhall, F, Blyth, K G, Brenton, J D, Chaturvedi, A, Clarke, N, Dick, C, Evans, T R J, Hall, G, Hanby, A M, Harrison, D J, Johnston, S R D, Mason, M D, Morton, D, Newton-Bishop, J, Nicholson, A G, Oien, K A, Popat, S, Rassl, D, Sharpe, R, Taniere, P, Walker, I, Wallace, W A, West, N P, Butler, R, Gonzalez de Castro, D, Griffiths, M & Johnson, P W M 2018, ' Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme ', ESMO Open, vol. 3, no. 6, e000408 . https://doi.org/10.1136/esmoopen-2018-000408
This study was supported by Cancer Research UK, AstraZeneca and Pfizer UK. Introduction: Phase I of the Cancer Research UK Stratified Medicine Programme (SMP1) was designed to roll out molecular pathology testing nationwide at the point of cancer dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8dd6fc53c00de7cc8875310844425e
Autor:
Thomas B.K. Watkins, Amanda Farley, Maria Antonietta Cerone, Martin Forster, Alison Brewster, Adam Dangoor, Peter Fletcher, Melanie Mackean, David Gilligan, Elizabeth Toy, Sanjay Popat, Gary Middleton, Rowena Sharpe, Joshua Savage, Alastair Greystoke, James Spicer, Dee Wherton, Yvonne Summers, Noelle O'Rourke, Tara C. Mills, Judith Cave, Timothy A. Yap, Emilia L. Lim, P. Jain, Charles Swanton, Lucinda Billingham, Manita Mehmi
Publikováno v:
Nature. 585:E21-E21