Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis

Autor: Justin J. Rochford, Evelyne M. Aubry, Rowena J. Dennis, Michael J.O. Wakelam, Stephen O'Rahilly, Christopher E. Lowe, Qifeng Zhang

Publikováno v: Obesity. 21:1823-1829

Objective Decreased expression of diacylglycerol kinase delta (DGKδ) has been linked to insulin resistance in humans and mice and it is abundantly expressed in adipose tissue. Therefore, its role in adipogenesis was examined. Design and Methods 3T3-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f96190791c9fbd8a7bd7eaac216b53d2
https://doi.org/10.1002/oby.20297

Analyzing the functions and structure of the human lipodystrophy protein seipin

Autor: M F Michelle, Sim, Mesbah Uddin, Talukder, Rowena J, Dennis, J Michael, Edwardson, Justin J, Rochford

Publikováno v: Methods in enzymology. 537

Disruption of the gene BSCL2, which encodes the protein seipin, causes severe generalized lipodystrophy in humans with a near complete absence of adipose tissue. Moreover, cell culture studies have demonstrated that seipin plays a critical cell-auton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d853ce13bd97a86ab5c3611189e0c88
https://pubmed.ncbi.nlm.nih.gov/24480346

Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms

Autor: Mesbah Uddin Talukder, J. Michael Edwardson, Stephen O'Rahilly, Rowena J. Dennis, M.F. Michelle Sim, Justin J. Rochford

Publikováno v: Diabetologia

Aims/hypothesis In humans, disruption of the gene BSCL2, encoding the protein seipin, causes congenital generalised lipodystrophy (CGL) with severe insulin resistance and dyslipidaemia. While the causative gene has been known for over a decade, the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1569f824d2e4ca4d8f253516f14c4656
https://pubmed.ncbi.nlm.nih.gov/23989774

Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis

Autor: Rowena J. Dennis, Justin J. Rochford, Stephen O'Rahilly, U Obi, Christopher E. Lowe

Publikováno v: International Journal of Obesity (2005)

The unfolded protein response (UPR) is activated by endoplasmic reticulum stress resulting from an accumulation of unfolded or mis-folded proteins. The UPR is divided into three arms, involving the activation of ATF-6, PERK and IRE-1, that together a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9770236432859ee3318d964d72e28117
https://pubmed.ncbi.nlm.nih.gov/22124452

Neuroanatomical Characterisation of the Expression of the Lipodystrophy and Motor-Neuropathy Gene Bscl2 in Adult Mouse Brain

Autor: Daisuke Ito, Rowena J. Dennis, Justin J. Rochford, Alastair S. Garfield, Lora K. Heisler, Wai S. Chan

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45790 (2012)
Garfield, A S, Chan, W S, Dennis, R J, Ito, D, Heisler, L K & Rochford, J J 2012, ' Neuroanatomical characterisation of the expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain ', PLoS ONE, vol. 7, no. 9, pp. e45790 . https://doi.org/10.1371/journal.pone.0045790
PLoS ONE

The endoplasmic reticulum localised protein seipin, encoded by the gene Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), serves a critical but poorly defined function in the physiology of both adipose and neural tissue. In humans, BSCL2 los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70df2c6716232b5d621a561d8fe833f4
https://doi.org/10.1371/journal.pone.0045790