Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Autor: Kathrin Schmich, Christoph Meyer, Steven Dooley, Gerd A. Kullak-Ublick, Daniel J. Maltman, Ernst H. K. Stelzer, Jessica Mwinyi, Valentina Fonsato, Albert Braeuning, Melvin E. Andersen, María José Gómez-Lechón, Georg Damm, Philip Hewitt, J. Craig Rowlands, Jingbo Pi, Lena Gustavsson, Chong Su Cho, Stefan Przyborski, Thomas S. Weiss, Joanna Fraczek, Ute Albrecht, Regina Stöber, Britta Burkhardt, Adam S. Hayward, Sudin Bhattacharya, Bruno Stieger, Tamara Vanhaecke, Cliff Rowe, Kathy Yarborough, Celine Schelcher, Neil R. Cameron, Andreas K. Nussler, Seddik Hammad, Rowena Eakins, Olaf Dirsch, Dean J. Naisbitt, Dieter Häussinger, Robert A. Budinsky, Karine Sá Ferreira, Christopher E. Goldring, Jennifer Luebke-Wheeler, Giovanni Camussi, J. Brian Houston, Jennifer Bolleyn, Andrew Gibson, Patrick D. McMullen, Hermann-Georg Holzhütter, Michael Schwarz, Peng Lu, Jens M. Kelm, Francesco Pampaloni, Christelle Guyot, Jens Hrach, Uta Dahmen, J Böttger, Nicola J. Hewitt, Bijay Singh, Verena Keitel, Christoph Borner, Yuichi Sugiyama, Anna Lutz, Edward L. LeCluyse, Patricio Godoy, Simon Messner, Dirk Drasdo, Nariman Ansari, Courtney G. Woods, Irmgard Merfort, Rolf Gebhardt, María Teresa Donato, Yun Jaie Choi, Claus Kordes, B. Kevin Park, Jan G. Hengstler, Jinghai James Xu, Stefan Hoehme, Claus Hellerbrand, Peter Olinga, Hartmut Jaeschke, Linda J. Pluta, Agata Widera, Johannes G. Bode, Anup Ramachandran, Kiyomi Ito, Matthias Glanemann, David Hallifax, Geny M. M. Groothuis, Wolfgang E. Thasler, Mathieu Vinken, Ciro Tetta, Vera Rogiers, Madlen Matz-Soja, Jian Dong

Publikováno v: ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Archives of toxicology, 2013, Vol.87(8), pp.1315-1530 [Peer Reviewed Journal]
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2013, 87 (8), pp.1315-530. ⟨10.1007/s00204-013-1078-5⟩
Vrije Universiteit Brussel
Archives of Toxicology Vol. 87 Issue 8: pp. 1315-1530
Archives of Toxicology, 2013, 87 (8), pp.1315-530. ⟨10.1007/s00204-013-1078-5⟩
Archives of Toxicology; Vol 87
RODERIC. Repositorio Institucional de la Universitat de Valéncia
Archives of Toxicology; 87(8), pp 1315-1530 (2013)

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocyte

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