Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Rowena E. Martin"'
Autor:
Joy M. Zeng, Sanduni V. Hapuarachchi, Sarah H. Shafik, Rowena E. Martin, Kiaran Kirk, Giel G. van Dooren, Adele M. Lehane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Toxoplasma gondii and Plasmodium falciparum parasites both extrude l-lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, PfFNT, mediates l-lactate transport across the plasma membrane of P. falciparum parasites
Externí odkaz:
https://doaj.org/article/2487d4ef217541f185f3c2fd767c2794
Autor:
Sarah H. Shafik, Simon A. Cobbold, Kawthar Barkat, Sashika N. Richards, Nicole S. Lancaster, Manuel Llinás, Simon J. Hogg, Robert L. Summers, Malcolm J. McConville, Rowena E. Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or meta
Externí odkaz:
https://doaj.org/article/e62a9cfeb1b74e3793184dbfb72b16f7
Autor:
Vicky Zhang, Robert Kucharski, Courtney Landers, Sashika N. Richards, Stefan Bröer, Rowena E. Martin, Ryszard Maleszka
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Dopamine is an important neuromodulator involved in reward-processing, movement control, motivational responses, and other aspects of behavior in most animals. In honey bees (Apis mellifera), the dopaminergic system has been implicated in an elaborat
Externí odkaz:
https://doaj.org/article/20f8e7c6d3f944c7907faaaef43fb3c0
Autor:
M. Isabel Veiga, Satish K. Dhingra, Philipp P. Henrich, Judith Straimer, Nina Gnädig, Anne-Catrin Uhlemann, Rowena E. Martin, Adele M. Lehane, David A. Fidock
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Antimalarial chemotherapy relies on combination therapies (ACTs) consisting of an artemisinin derivative and a partner drug. Here, the authors study the effects of globally prevalent mutations in a multidrug resistance transporter (PfMDR1) on the par
Externí odkaz:
https://doaj.org/article/dbb046e77b4e470caabc3ad9b066a983
Autor:
Rongwei Teng, Adele M. Lehane, Markus Winterberg, Sarah H. Shafik, Robert L. Summers, Rowena E. Martin, Donelly A. van Schalkwyk, Pauline R. Junankar, Kiaran Kirk
Publikováno v:
Bioscience Reports, Vol 34, Iss 6, p e00150 (2014)
Although efforts to understand the basis for inter-strain phenotypic variation in the most virulent malaria species, Plasmodium falciparum, have benefited from advances in genomic technologies, there have to date been few metabolomic studies of this
Externí odkaz:
https://doaj.org/article/79e6cb79e4e447f4a0c5f2ff98fde3f5
Autor:
Rowena E. Martin
Publikováno v:
Biological Reviews. 95:305-332
Membrane transport proteins, also known as transporters, control the movement of ions, nutrients, metabolites, and waste products across the membranes of a cell and are central to its biology. Proteins of this type also serve as drug targets and are
Autor:
Robert L. Summers, Annette Habluetzel, Stefania Lamponi, Sandra Gemma, Rowena E. Martin, Sarah H. Shafik, Stefano Federico, Reto Caldelari, Donatella Taramelli, Luca Pozzetti, Giuseppe Campiani, Sarah D'Alessandro, Stefania Butini, Simone K. Babij, Nicola Relitti, Sofia Tapanelli
Due to the surge in resistance to common therapies, malaria remains a significant concern to human health worldwide. In chloroquine (CQ)-resistant (CQ-R) strains of Plasmodium falciparum, CQ and related drugs are effluxed from the parasite’s digest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8956bb26e1162a62798dcc944865de
http://hdl.handle.net/11365/1141531
http://hdl.handle.net/11365/1141531
Autor:
Alex Joule, Alice Patterson-Robert, Zachary R. Sailer, Michael J. Harms, Rowena E. Martin, Sarah H. Shafik, Robert L. Summers
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008243 (2020)
PLoS Computational Biology
PLoS Computational Biology
Understanding evolution requires detailed knowledge of genotype-phenotype maps; however, it can be a herculean task to measure every phenotype in a combinatorial map. We have developed a computational strategy to predict the missing phenotypes from a
Autor:
Giel G. van Dooren, Sanduni V. Hapuarachchi, Kiaran Kirk, Joy M Zeng, Adele M. Lehane, Rowena E. Martin, Sarah H. Shafik
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Toxoplasma gondii and Plasmodium falciparum parasites both extrude l-lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, PfFNT, mediates l-lactate transport across the plasma membrane of P. falciparum parasites and has
Autor:
Sashika N. Richards, Courtney Landers, Stefan Bröer, Robert Kucharski, Vicky Zhang, Ryszard Maleszka, Rowena E. Martin
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology
Frontiers in Physiology
Dopamine is an important neuromodulator involved in reward-processing, movement control, motivational responses, and other aspects of behaviour in most animals. In honey bees (Apis mellifera), the dopaminergic system has been implicated in an elabora