Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Rowena E. Martin"'
Autor:
Joy M. Zeng, Sanduni V. Hapuarachchi, Sarah H. Shafik, Rowena E. Martin, Kiaran Kirk, Giel G. van Dooren, Adele M. Lehane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Toxoplasma gondii and Plasmodium falciparum parasites both extrude l-lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, PfFNT, mediates l-lactate transport across the plasma membrane of P. falciparum parasites
Externí odkaz:
https://doaj.org/article/2487d4ef217541f185f3c2fd767c2794
Autor:
Sarah H. Shafik, Simon A. Cobbold, Kawthar Barkat, Sashika N. Richards, Nicole S. Lancaster, Manuel Llinás, Simon J. Hogg, Robert L. Summers, Malcolm J. McConville, Rowena E. Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or meta
Externí odkaz:
https://doaj.org/article/e62a9cfeb1b74e3793184dbfb72b16f7
Autor:
Zachary R Sailer, Sarah H Shafik, Robert L Summers, Alex Joule, Alice Patterson-Robert, Rowena E Martin, Michael J Harms
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008243 (2020)
Understanding evolution requires detailed knowledge of genotype-phenotype maps; however, it can be a herculean task to measure every phenotype in a combinatorial map. We have developed a computational strategy to predict the missing phenotypes from a
Externí odkaz:
https://doaj.org/article/020e794cc46b429399bb79a85a12ccc8
Autor:
Vicky Zhang, Robert Kucharski, Courtney Landers, Sashika N. Richards, Stefan Bröer, Rowena E. Martin, Ryszard Maleszka
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Dopamine is an important neuromodulator involved in reward-processing, movement control, motivational responses, and other aspects of behavior in most animals. In honey bees (Apis mellifera), the dopaminergic system has been implicated in an elaborat
Externí odkaz:
https://doaj.org/article/20f8e7c6d3f944c7907faaaef43fb3c0
Autor:
M. Isabel Veiga, Satish K. Dhingra, Philipp P. Henrich, Judith Straimer, Nina Gnädig, Anne-Catrin Uhlemann, Rowena E. Martin, Adele M. Lehane, David A. Fidock
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Antimalarial chemotherapy relies on combination therapies (ACTs) consisting of an artemisinin derivative and a partner drug. Here, the authors study the effects of globally prevalent mutations in a multidrug resistance transporter (PfMDR1) on the par
Externí odkaz:
https://doaj.org/article/dbb046e77b4e470caabc3ad9b066a983
Autor:
Sanduni V Hapuarachchi, Simon A Cobbold, Sarah H Shafik, Adelaide S M Dennis, Malcolm J McConville, Rowena E Martin, Kiaran Kirk, Adele M Lehane
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006180 (2017)
In this study the 'Malaria Box' chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH of the malaria parasite, Plasmodium falciparum. Fifteen compounds induced an acidification
Externí odkaz:
https://doaj.org/article/af29320f19f24b8b9d2b5dfd5482a5da
Autor:
Sashika N Richards, Megan N Nash, Eileen S Baker, Michael W Webster, Adele M Lehane, Sarah H Shafik, Rowena E Martin
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005725 (2016)
Mutations in the Plasmodium falciparum 'chloroquine resistance transporter' (PfCRT) confer resistance to chloroquine (CQ) and related antimalarials by enabling the protein to transport these drugs away from their targets within the parasite's digesti
Externí odkaz:
https://doaj.org/article/c5c24d1b429c4890955f2192f5a69ecb
Autor:
Rowena E. Martin
Publikováno v:
Biological Reviews. 95:305-332
Membrane transport proteins, also known as transporters, control the movement of ions, nutrients, metabolites, and waste products across the membranes of a cell and are central to its biology. Proteins of this type also serve as drug targets and are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5af55dbed5a8b30fa51b0de00437c03
https://doi.org/10.1111/brv.12565
https://doi.org/10.1111/brv.12565
Autor:
Robert L. Summers, Annette Habluetzel, Stefania Lamponi, Sandra Gemma, Rowena E. Martin, Sarah H. Shafik, Stefano Federico, Reto Caldelari, Donatella Taramelli, Luca Pozzetti, Giuseppe Campiani, Sarah D'Alessandro, Stefania Butini, Simone K. Babij, Nicola Relitti, Sofia Tapanelli
Due to the surge in resistance to common therapies, malaria remains a significant concern to human health worldwide. In chloroquine (CQ)-resistant (CQ-R) strains of Plasmodium falciparum, CQ and related drugs are effluxed from the parasite’s digest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8956bb26e1162a62798dcc944865de
http://hdl.handle.net/11365/1141531
http://hdl.handle.net/11365/1141531
Autor:
Alex Joule, Alice Patterson-Robert, Zachary R. Sailer, Michael J. Harms, Rowena E. Martin, Sarah H. Shafik, Robert L. Summers
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008243 (2020)
PLoS Computational Biology
PLoS Computational Biology
Understanding evolution requires detailed knowledge of genotype-phenotype maps; however, it can be a herculean task to measure every phenotype in a combinatorial map. We have developed a computational strategy to predict the missing phenotypes from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8101258a3c1a18ebec96e6ffceca91
https://doaj.org/article/020e794cc46b429399bb79a85a12ccc8
https://doaj.org/article/020e794cc46b429399bb79a85a12ccc8