Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rowena DeJesus"'
Autor:
Xiaomeng Hu, Karl Manner, Rowena DeJesus, Kathy White, Corie Gattis, Priscilla Ngo, Christopher Bandoro, Eleonore Tham, Elaine Y. Chu, Chi Young, Frank Wells, Ronald Basco, Annabelle Friera, Divy Kangeyan, Pascal Beauchesne, William E. Dowdle, Tobias Deuse, Terry J. Fry, Aaron E. Foster, Sonja Schrepfer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Manufacturing autologous chimeric antigen receptor (CAR) T cell therapeutics is complex, and many patients experience treatment delays or cannot be treated at all. Although current allogeneic CAR products have the potential to overcome manuf
Externí odkaz:
https://doaj.org/article/11a7498d8b624c7f9293ade72a94e6d3
Autor:
Jonathan M. Goodwin, William E. Dowdle, Rowena DeJesus, Zuncai Wang, Philip Bergman, Marek Kobylarz, Alicia Lindeman, Ramnik J. Xavier, Gregory McAllister, Beat Nyfeler, Gregory Hoffman, Leon O. Murphy
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2341-2356 (2017)
Iron is vital for many homeostatic processes, and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are targeted to lysosomes by a form of sele
Externí odkaz:
https://doaj.org/article/24a5ed36c1ec4393b84541c3dfccc45e
Autor:
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler
Publikováno v:
eLife, Vol 5 (2016)
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-
Externí odkaz:
https://doaj.org/article/740ed0340cbe47708079afcf989db0dd
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003725 (2013)
Correct repair of damaged DNA is critical for genomic integrity. Deficiencies in DNA repair are linked with human cancer. Here we report a novel mechanism by which a virus manipulates DNA damage responses. Infection with murine polyomavirus sensitize
Externí odkaz:
https://doaj.org/article/8fe3dc795a2d4053bc6f9d7bd01ecfa6
Autor:
Xiaomeng Hu, Kathy White, Ari G. Olroyd, Rowena DeJesus, Antonia A. Dominguez, William E. Dowdle, Annabelle M. Friera, Chi Young, Frank Wells, Elaine Y. Chu, Cade Ellis Ito, Harini Krishnapura, Surbhi Jain, Ramya Ankala, Trevor J. McGill, August Lin, Kyla Egenberger, Allison Gagnon, J. Michael Rukstalis, Nathaniel J. Hogrebe, Corie Gattis, Ron Basco, Jeffrey R. Millman, Paul Kievit, Mark M. Davis, Lewis L. Lanier, Andrew J. Connolly, Tobias Deuse, Sonja Schrepfer
Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a recipient’s immune system would abolish the requirement for immunosuppressive drugs or encapsulation and support large-scale manufacturing of off-the-shelf cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736dc650159ca6f52d32a1fd001b395d
https://escholarship.org/uc/item/95k656c6
https://escholarship.org/uc/item/95k656c6
Autor:
Marek J. Kobylarz, Leon Murphy, William E. Dowdle, Rowena DeJesus, Jonathan M. Goodwin, Alicia Lindeman, Beat Nyfeler, Gregory McAllister, Zuncai Wang, Gregory R. Hoffman, Ramnik J. Xavier, Philip Bergman
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2341-2356 (2017)
Iron is vital for many homeostatic processes and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are targeted to lysosomes by a form of selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef54941eaa793724f625867ca74b743
https://doi.org/10.1016/j.celrep.2017.08.034
https://doi.org/10.1016/j.celrep.2017.08.034
Autor:
Leon Murphy, Zhao Kang, Zinger Yang, Debora Bonenfant, Isabelle Claerr, Rowena DeJesus, Carsten Russ, Matthias Mueller, Damien Begue, John S. Reece-Hoyes, Christophe Antczak, Alexandra Graff, Christel Genoud, Beat Nyfeler, Jonathan M. Goodwin, Phil Bergman, Gregory R. Hoffman, Stacie Dodgson, Ramnik J. Xavier, David Marcellin, Francesca Moretti
Publikováno v:
EMBO reports. 19(9)
Autophagy maintains cellular homeostasis by targeting damaged organelles, pathogens, or misfolded protein aggregates for lysosomal degradation. The autophagic process is initiated by the formation of autophagosomes, which can selectively enclose carg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43071a607a570d860027cb250ff853f2
https://pubmed.ncbi.nlm.nih.gov/30131347
https://pubmed.ncbi.nlm.nih.gov/30131347
Autor:
Rowena DeJesus, Andreas W. Sailer, Stephen B. Helliwell, Gregory McAllister, John S. Reece-Hoyes, Christophe Crochemore, Florian Nigsch, Carsten Russ, Christoph Potting, Walter Carbone, Matthias Müller, Judith Knehr, Gregory R. Hoffman, Alicia Lindeman, Carole Manneville, Isabel Schmidt, Guglielmo Roma, Francesca Moretti, Rob Maher
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(2)
PARKIN, an E3 ligase mutated in familial Parkinson's disease, promotes mitophagy by ubiquitinating mitochondrial proteins for efficient engagement of the autophagy machinery. Specifically, PARKIN-synthesized ubiquitin chains represent targets for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c5ced1e029a55badaa93d25ae39bed
https://pubmed.ncbi.nlm.nih.gov/30150395
https://pubmed.ncbi.nlm.nih.gov/30150395
Autor:
Zuncai Wang, Walter Carbone, Jennifer Kelliher, Rowena DeJesus, Guglielmo Roma, John S. Reece-Hoyes, Aylwin Ng, Francesca Moretti, Craig Mickanin, Phil Bergman, Alicia Lindeman, Shanming Liu, Gregory R. Hoffman, John Alford, Martin Beibel, Beat Nyfeler, Leon Murphy, Carsten Russ, John A. Tallarico, Gregory McAllister, Judith Knehr, Ramnik J. Xavier, Elizabeth Frias, Jeffery A. Porter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969d0bf3b951cb089bc956ceb830f70e
https://doi.org/10.7554/elife.17290.014
https://doi.org/10.7554/elife.17290.014
Autor:
Craig Mickanin, Gregory R. Hoffman, Jeffery A. Porter, Guglielmo Roma, Carsten Russ, Gregory McAllister, Walter Carbone, John A. Tallarico, Beat Nyfeler, Zuncai Wang, Jennifer Kelliher, Francesca Moretti, Ramnik J. Xavier, Leon Murphy, John S. Reece-Hoyes, John Alford, Phil Bergman, Alicia Lindeman, Elizabeth Frias, Shanming Liu, Rowena DeJesus, Judith Knehr, Martin Beibel, Aylwin Ng
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4076c6c00fbbd9562afd9c0e08da058
https://pubmed.ncbi.nlm.nih.gov/27351204
https://pubmed.ncbi.nlm.nih.gov/27351204