Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control.

Autor: Weiss SA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA., Huang AY; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Fung ME; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Martinez D; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Chen ACY; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., LaSalle TJ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Miller BC; Department of Medicine, Division of Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Scharer CD; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, USA., Hegde M; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Nguyen TH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Rowe JH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Osborn JF; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Patterson DG; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Sifnugel N; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Mei-An Nolan C; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Davidson RA; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Schwartz MA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Bally APR; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, USA., Neeld DK; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, USA., LaFleur MW; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Boss JM; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, USA., Doench JG; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Nicholas Haining W; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; ArsenalBio, San Francisco, CA, USA., Sharpe AH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. arlene_sharpe@hms.harvard.edu.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. arlene_sharpe@hms.harvard.edu.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA. arlene_sharpe@hms.harvard.edu.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. arlene_sharpe@hms.harvard.edu., Sen DR; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA. dsen@mgh.harvard.edu.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. dsen@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. dsen@mgh.harvard.edu.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA. dsen@mgh.harvard.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Oct; Vol. 25 (10), pp. 1871-1883. Date of Electronic Publication: 2024 Sep 17.

Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade.

Autor: Rowe JH; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts., Elia I; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Shahid O; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts., Gaudiano EF; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts., Sifnugel NE; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts., Johnson S; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts., Reynolds AG; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Fung ME; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts., Joshi S; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts., LaFleur MW; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts., Park JS; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts., Pauken KE; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts., Rabinowitz JD; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Haigis MC; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts., Sharpe AH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

Publikováno v: Cancer discovery [Cancer Discov] 2023 Dec 12; Vol. 13 (12), pp. 2566-2583.

Severe congenital neutropenia due to jagunal homolog 1 ( JAGN1 ) mutation: a case report and literature review.

Autor: Thomas S; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, United States.; Harvard Medical School, Boston, MA, United States., Guenther G; Harvard Medical School, Boston, MA, United States.; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States., Rowe JH; Harvard Medical School, Boston, MA, United States.; Division of Hematology, Boston Children's Hospital and Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Platt CD; Harvard Medical School, Boston, MA, United States.; Division of Immunology, Boston Children's Hospital, Boston, MA, United States., Shimamura A; Harvard Medical School, Boston, MA, United States.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Levy O; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, United States.; Harvard Medical School, Boston, MA, United States.; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.; Broad Institute of MIT & Harvard, Cambridge, MA, United States., Ganapathi L; Harvard Medical School, Boston, MA, United States.; Division of Pediatric Global Health, Massachusetts General Hospital, Boston, MA, United States.; Division of Pediatric Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States.

Publikováno v: Frontiers in pediatrics [Front Pediatr] 2023 Jul 17; Vol. 11, pp. 1223191. Date of Electronic Publication: 2023 Jul 17 (Print Publication: 2023).