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Administration of mesenchymal stromal cells before renal ischemia/reperfusion attenuates kidney injury and may modulate renal lipid metabolism in rats

Autor: Pauline Erpicum, Pascal Rowart, Laurence Poma, Jean-Marie Krzesinski, Olivier Detry, François Jouret

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract Mesenchymal stromal cells (MSC) have been demonstrated to attenuate renal ischemia/reperfusion (I/R) damage in rodent models. The mechanisms of such nephro-protection remain largely unknown. Furthermore, the optimal timing of MSC administrat

Externí odkaz: https://doaj.org/article/9ec433427a5049e4a7f1d12dad683f10

Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1

Autor: P. Rowart, P. Erpicum, J.-M. Krzesinski, M. Sebbagh, F. Jouret

Publikováno v: Stem Cells International, Vol 2017 (2017)

Background. Mesenchymal stromal cells (MSC) are fibroblast-like multipotent cells capable of tissue-repair properties. Given the essentiality of tight junctions (TJ) in epithelial integrity, we hypothesized that MSC modulate TJ formation, via the AMP

Externí odkaz: https://doaj.org/article/bd7e292731b24d50aa14e77a78f3cc0c

The genetic deletion of the Dual Specificity Phosphatase 3 (DUSP3) attenuates kidney damage and inflammation following ischaemia/reperfusion injury in mouse.

Autor: Khbouz B; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), Liège, Belgium., Rowart P; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), Liège, Belgium.; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Poma L; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), Liège, Belgium., Dahlke E; Institute of Anatomy, Christian Albrechts-University, Kiel, Germany., Bottner M; Institute of Anatomy, Christian Albrechts-University, Kiel, Germany., Stokes M; Cell Signaling Technology, Inc., Danvers, Massachusetts, USA., Bolen G; Department of Clinical Sciences, Fundamental and Applied Research for Animals & Health (FARAH), Veterinary Faculty, University of Liège (ULiège), Liège, Belgium., Rahmouni S; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Medical Genomics, University of Liège (ULiège), Liège, Belgium., Theilig F; Institute of Anatomy, Christian Albrechts-University, Kiel, Germany.; Institute of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland., Jouret F; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), Liège, Belgium.; Division of Nephrology, CHU of Liège, University of Liège (CHU ULiège), Liège, Belgium.

Publikováno v: Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2022 Feb; Vol. 234 (2), pp. e13735. Date of Electronic Publication: 2021 Nov 09.

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