Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Rowan Miller"'
Autor:
James Spicer, Bristi Basu, Ana Montes, Udai Banerji, Rebecca Kristeleit, Rowan Miller, Gareth J. Veal, Christopher J. Corrigan, Stephen J. Till, Mariangela Figini, Silvana Canevari, Claire Barton, Paul Jones, Sarah Mellor, Simon Carroll, Chris Selkirk, George Nintos, Vineet Kwatra, Ionut-Gabriel Funingana, Gary Doherty, Hannah J. Gould, Giulia Pellizzari, Mano Nakamura, Kristina M. Ilieva, Atousa Khiabany, Chara Stavraka, Jitesh Chauhan, Cheryl Gillett, Sarah Pinder, Heather J. Bax, Debra H. Josephs, Sophia N. Karagiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT025
Externí odkaz:
https://doaj.org/article/10c6fe5134614037a52da348794ee12d
Autor:
Ana Oaknin, Maria-Pilar Barretina-Ginesta, Victor Moreno, Thierry André, Ruth Plummer, Florence Joly, Rowan Miller, Joanna Pikiel, Susana Banerjee, Jose Manuel Trigo Perez, Bhavana Pothuri, Andrea Jewell, Anna Tinker, Dominique Berton, Susan Ellard, Jennifer Veneris, Tao Duan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/d39ea0b42267479e959567a5b2a0f1fd
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Externí odkaz:
https://doaj.org/article/6084c0274ae249718e485f2a37c80da7
Autor:
Chris T. Williamson, Rowan Miller, Helen N. Pemberton, Samuel E. Jones, James Campbell, Asha Konde, Nicholas Badham, Rumana Rafiq, Rachel Brough, Aditi Gulati, Colm J. Ryan, Jeff Francis, Peter B. Vermulen, Andrew R. Reynolds, Philip M. Reaper, John R. Pollard, Alan Ashworth, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Mutations in the BAF SWI/SNF complex subunits are frequent in cancers but selective therapeutic approaches are not available yet. Here, the authors demonstrate that defects ofARID1Aand other subunits sensitizes cancer cells to the DNA checkpoint kina
Externí odkaz:
https://doaj.org/article/e641244f3cf24d9e87d1e6540b5b48bf
Autor:
James Campbell, Colm J. Ryan, Rachel Brough, Ilirjana Bajrami, Helen N. Pemberton, Irene Y. Chong, Sara Costa-Cabral, Jessica Frankum, Aditi Gulati, Harriet Holme, Rowan Miller, Sophie Postel-Vinay, Rumana Rafiq, Wenbin Wei, Chris T. Williamson, David A. Quigley, Joe Tym, Bissan Al-Lazikani, Timothy Fenton, Rachael Natrajan, Sandra J. Strauss, Alan Ashworth, Christopher J. Lord
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2490-2501 (2016)
One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell lines. Here, we describe data from a series of siRNA screens that identify the kinase genetic dependencies in 117 ca
Externí odkaz:
https://doaj.org/article/381f961b73404d2fa41627417ce941fc
Autor:
Michael-John Devlin, Rowan Miller
Publikováno v:
International Journal of Gynecologic Cancer. 33:358-363
Understanding the genomic complexity of high-grade serous ovarian cancer is now essential in guiding patient management, particularly in the first-line setting. Our knowledge in this area has expanded rapidly in recent years, with biomarkers developi
Autor:
Frances R. Balkwill, Eleni Maniati, Jacqueline McDermott, David D. Bowtell, Rebecca Kristeleit, Dale W. Garsed, Panoraia Kotantaki, Florian Laforets, Rowan Miller, Michael-John Devlin
Some patients with advanced clear-cell ovarian cancer (CCOC) respond to immunotherapy; however, little is known about the tumor microenvironment (TME) of this relatively rare disease. Here, we describe a comprehensive quantitative and topographical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52749b1e5bf69beb0cbaba8b638c10e4
https://doi.org/10.1158/2326-6066.c.6550844
https://doi.org/10.1158/2326-6066.c.6550844
Autor:
Frances R. Balkwill, Eleni Maniati, Jacqueline McDermott, David D. Bowtell, Rebecca Kristeleit, Dale W. Garsed, Panoraia Kotantaki, Florian Laforets, Rowan Miller, Michael-John Devlin
Supplementary Data from The Tumor Microenvironment of Clear-Cell Ovarian Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e61a7ba2340c61b7783fccf4a4e1559
https://doi.org/10.1158/2326-6066.22545056.v1
https://doi.org/10.1158/2326-6066.22545056.v1
Autor:
Johann S. de Bono, Yvette Drew, Juanita S. Lopez, Bristi Basu, Ruth Plummer, Udai Banerji, Christopher J. Lord, Andrew Foxley, Justin P.O. Lindemann, Paul Rugman, Emma Hall, Laura Finneran, Karen E. Swales, Shaun Decordova, Florence I. Raynaud, Ruth Ruddle, Nicholas C. Turner, Heidrun Gevensleben, Neha Chopra, Nina Tunariu, Alison Turner, Mona Parmar, Ruth Matthews, Sarah Ward, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Rowan Miller, Desamparados Roda, Suzanne Carreira, Joline S.J. Lim, Stephen J. Pettitt, Vasiliki Michalarea, Rebecca Kristeleit, Timothy A. Yap
Preclinical studies have demonstrated synergy between PARP and PI3K/AKT pathway inhibitors in BRCA1 and BRCA2 (BRCA1/2)–deficient and BRCA1/2-proficient tumors. We conducted an investigator-initiated phase I trial utilizing a prospective intrapatie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01e33adbfd1faf3496d00cefbd4e1d17
https://doi.org/10.1158/2159-8290.c.6547955.v1
https://doi.org/10.1158/2159-8290.c.6547955.v1
Autor:
Johann S. de Bono, Yvette Drew, Juanita S. Lopez, Bristi Basu, Ruth Plummer, Udai Banerji, Christopher J. Lord, Andrew Foxley, Justin P.O. Lindemann, Paul Rugman, Emma Hall, Laura Finneran, Karen E. Swales, Shaun Decordova, Florence I. Raynaud, Ruth Ruddle, Nicholas C. Turner, Heidrun Gevensleben, Neha Chopra, Nina Tunariu, Alison Turner, Mona Parmar, Ruth Matthews, Sarah Ward, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Rowan Miller, Desamparados Roda, Suzanne Carreira, Joline S.J. Lim, Stephen J. Pettitt, Vasiliki Michalarea, Rebecca Kristeleit, Timothy A. Yap
Supplementary Tables 1-7; Supplementary Figures 1-2; Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b42dc1c2ce5b8015019651ef216b42
https://doi.org/10.1158/2159-8290.22535825
https://doi.org/10.1158/2159-8290.22535825