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pro vyhledávání: '"Rowan Howell"'
Autor:
Rowan Howell, Matthew A. Clarke, Ann-Kathrin Reuschl, Tianyi Chen, Sean Abbott-Imboden, Mervyn Singer, David M. Lowe, Clare L. Bennett, Benjamin Chain, Clare Jolly, Jasmin Fisher
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-13 (2022)
Abstract The COVID-19 pandemic has pushed healthcare systems globally to a breaking point. The urgent need for effective and affordable COVID-19 treatments calls for repurposing combinations of approved drugs. The challenge is to identify which combi
Externí odkaz:
https://doaj.org/article/138f70666aaf4bca914664c7e630f7d8
Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling
Autor:
Rowan Howell, James Davies, Matthew A. Clarke, Anna Appios, Inês Mesquita, Yashoda Jayal, Ben Ringham-Terry, Isabel Boned Del Rio, Jasmin Fisher, Clare L. Bennett
Publikováno v:
Science Advances. 9
While skin is a site of active immune surveillance, primary melanomas often escape detection. Here, we have developed an in silico model to determine the local cross-talk between melanomas and Langerhans cells (LCs), the primary antigen-presenting ce