Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Rovshan G Sadygov"'
Autor:
Mahbubur Rahman, Rovshan G Sadygov
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180428 (2017)
Protein half-life is an important feature of protein homeostasis (proteostasis). The increasing number of in vivo and in vitro studies using high throughput proteomics provide estimates of the protein half-lives in tissues and cells. However, protein
Externí odkaz:
https://doaj.org/article/cb912d71235f46b98c4e31c6beb13796
Autor:
Jonathan M Starkey, Yingxin Zhao, Rovshan G Sadygov, Sigmund J Haidacher, Wanda S Lejeune, Nilay Dey, Bruce A Luxon, Maureen A Kane, Joseph L Napoli, Larry Denner, Ronald G Tilton
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11095 (2010)
Numerous metabolic pathways have been implicated in diabetes-induced renal injury, yet few studies have utilized unbiased systems biology approaches for mapping the interconnectivity of diabetes-dysregulated proteins that are involved. We utilized a
Externí odkaz:
https://doaj.org/article/540f78890a5d40b1ae89d76170f39b9f
Autor:
Henock M. Deberneh, Doaa R. Abdelrahman, Sunil K. Verma, Jennifer J. Linares, Andrew J. Murton, William K. Russell, Muge N. Kuyumcu-Martinez, Benjamin F. Miller, Rovshan G. Sadygov
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-11 (2023)
Abstract Metabolic stable isotope labeling with heavy water followed by liquid chromatography coupled with mass spectrometry (LC-MS) is a powerful tool for in vivo protein turnover studies. Several algorithms and tools have been developed to determin
Externí odkaz:
https://doaj.org/article/0900532a627d440b99e27ccff0f8914b
Autor:
Henock M. Deberneh, Doaa R. Abdelrahman, Sunil K. Verma, Jennifer J. Linares, Andrew J. Murton, William K. Russell, Muge N. Kuyumcu-Martinez, Benjamin F. Miller, Rovshan G. Sadygov
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Heavy water metabolic labeling followed by liquid chromatography coupled with mass spectrometry is a powerful high throughput technique for measuring the turnover rates of individual proteins in vivo. The turnover rate is obtained from the e
Externí odkaz:
https://doaj.org/article/2fd9fe96ab7f42029f30a4b802d31e12
Autor:
Henock M. Deberneh, Rovshan G. Sadygov
Publikováno v:
Journal of Proteome Research. 22:410-419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::418f6b346ff59ffdf6314377ca04b45a
https://doi.org/10.1021/acs.jproteome.2c00592
https://doi.org/10.1021/acs.jproteome.2c00592
Autor:
Rovshan G. Sadygov
Publikováno v:
J Proteome Res
Metabolic labeling followed by LC-MS-based proteomics is a powerful tool to study proteome dynamics in high-throughput experiments both in vivo and in vitro. High mass resolution and accuracy allow differentiation in isotope profiles and the quantifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76717971d4fb853c0e842ab5b4d5455f
https://doi.org/10.1021/acs.jproteome.0c00873
https://doi.org/10.1021/acs.jproteome.0c00873
Autor:
Ahmad Borzou, Rovshan G. Sadygov
Publikováno v:
Bioinformatics
Motivation Inferring the direct relationships between biomolecules from omics datasets is essential for the understanding of biological and disease mechanisms. Gaussian Graphical Model (GGM) provides a fairly simple and accurate representation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c815d89626f46bc9164ace48fcf51786
https://doi.org/10.1093/bioinformatics/btaa894
https://doi.org/10.1093/bioinformatics/btaa894
Publikováno v:
J Proteome Res
Protein homeostasis, proteostasis, is essential for healthy cell functioning and is dysregulated in many diseases. Metabolic labeling with heavy water followed by liquid chromatography coupled online to mass spectrometry (LC-MS) is a powerful high-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a6f97b70b50b812b583c4d05a7cbe9
https://doi.org/10.1021/acs.jproteome.0c00023
https://doi.org/10.1021/acs.jproteome.0c00023
Autor:
Henock M. Deberneh, Rovshan G. Sadygov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14620
Metabolic stable isotope labeling followed by liquid chromatography coupled with mass spectrometry (LC-MS) is a powerful tool for in vivo protein turnover studies of individual proteins on a large scale and with high throughput. Turnover rates of tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ff12e5e0d68fdd636a8af908182837
https://doi.org/10.3390/ijms232314620
https://doi.org/10.3390/ijms232314620
Autor:
Rovshan G. Sadygov
Publikováno v:
Anal Chem
Metabolic labeling with atom-based heavy isotopes, followed by liquid chromatography coupled with mass spectrometry (LC-MS), has been a powerful technique for studies of proteome and metabolome. In proteomics, the protein turnover of thousands of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2280a168593539e83afc3f86c05d1e
https://pubmed.ncbi.nlm.nih.gov/33084301
https://pubmed.ncbi.nlm.nih.gov/33084301