Immunotherapeutic targeting of surfaceome heterogeneity in AML.

Autor: Bordeleau ME; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada. Electronic address: marie.eve.bordeleau@umontreal.ca., Audemard É; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Métois A; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Theret L; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Lisi V; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC H3T 1C5, Canada., Farah A; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC H3T 1C5, Canada., Spinella JF; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Chagraoui J; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Moujaber O; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Aubert L; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Khakipoor B; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC H3T 1C5, Canada., Mallinger L; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Boivin I; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Mayotte N; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Hajmirza A; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Bonneil É; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Béliveau F; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada., Pfammatter S; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Feghaly A; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Boucher G; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Gendron P; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada., Thibault P; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Department of Chemistry, Faculty of Arts and Science, Université de Montréal, Montréal, QC H3T 1J4, Canada., Barabé F; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Centre de Recherche du Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC G1V 4G2, Canada., Lemieux S; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada. Electronic address: s.lemieux@umontreal.ca., Richard-Carpentier G; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Medicine, Division of Medical Oncology and Hematology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: guillaume.richard-carpentier@uhn.ca., Hébert J; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Division of Hematology-Oncology, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada. Electronic address: josee.hebert@umontreal.ca., Lavallée VP; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC H3T 1C5, Canada; Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Hematology and Oncology Division, Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC H3T 1C5, Canada. Electronic address: vincent-philippe.lavallee@umontreal.ca., Roux PP; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada. Electronic address: philippe.roux@umontreal.ca., Sauvageau G; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3T 1J4, Canada; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Division of Hematology-Oncology, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada. Electronic address: guy.sauvageau@umontreal.ca.

Publikováno v: Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114260. Date of Electronic Publication: 2024 Jun 04.

14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation.

Autor: Rial SA; Department of Medicine, Université de Montréal, Montreal, QC, Canada.; Cardiometabolic Axis, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada., You Z; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada., Vivoli A; Department of Medicine, Université de Montréal, Montreal, QC, Canada.; Cardiometabolic Axis, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada., Sean D; Department of Medicine, Université de Montréal, Montreal, QC, Canada.; Cardiometabolic Axis, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada., Al-Khoury A; Department of Medicine, Université de Montréal, Montreal, QC, Canada.; Cardiometabolic Axis, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada., Lavoie G; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, Canada.; Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada., Civelek M; Department of Biomedical Engineering, University of Virginia, Charlottesville, United States.; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908., Martinez-Sanchez A; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, UK., Roux Pp; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, Canada.; Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada., Durcan TM; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada., Lim GE; Department of Medicine, Université de Montréal, Montreal, QC, Canada.; Cardiometabolic Axis, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 19. Date of Electronic Publication: 2024 Mar 19.

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.

Autor: Gress V; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Roussy M; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Boulianne L; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Department of Pathology, McGill University, Montréal, QC, Canada., Bilodeau M; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Cardin S; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., El-Hachem N; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Lisi V; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Khakipoor B; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Rouette A; Molecular Diagnostic Laboratory, Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada., Farah A; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Théret L; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Aubert L; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Fatima F; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Department of Pathology, McGill University, Montréal, QC, Canada., Audemard É; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Thibault P; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Bonneil É; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Chagraoui J; Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer, Montréal, Québec, Canada., Laramée L; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Gendron P; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Jouan L; Molecular Diagnostic Laboratory, Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada., Jammali S; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Paré B; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Simpson SM; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Tran TH; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Duval M; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Teira P; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Bittencourt H; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Santiago R; Division of Hematology-Oncology, Centre Hospitalier Universitaire de Québec-Université Laval, Québec City, QC, Canada.; Centre de recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec City, QC, Canada., Barabé F; Centre de recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec City, QC, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Québec City, QC, Canada., Sauvageau G; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer, Montréal, Québec, Canada.; Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada., Smith MA; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Hébert J; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Division of Hematology-Oncology and Quebec Leukemia Cell Bank, Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada., Roux PP; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada.; Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Gruber TA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA., Lavallée VP; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Wilhelm BT; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Cellot S; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.

Publikováno v: Blood advances [Blood Adv] 2024 Jan 09; Vol. 8 (1), pp. 112-129.

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Autor: Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF

Publikováno v: Cell reports [Cell Rep] 2023 Dec 26; Vol. 42 (12), pp. 113604. Date of Electronic Publication: 2023 Dec 14.

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

Autor: Dervovic D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Malik AA; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Chen ELY; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Narimatsu M; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Adler N; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Afiuni-Zadeh S; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Krenbek D; Department of Pathology and Bacteriology, Klinik Floridsdorf, Vienna, Austria., Martinez S; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Boucher J; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, QC, Canada., Berman JM; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Teng K; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Ayyaz A; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Lü Y; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Mbamalu G; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Loganathan SK; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Otolaryngology, Head and Neck Surgery, McGill University, Montreal, QC, Canada., Lee J; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada., Zhang L; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Departments of Laboratory Medicine and Pathobiology, Immunology, University of Toronto, Toronto, ON, Canada., Guidos C; SickKids Research Institute, University Health Network, Toronto, ON, Canada., Wrana J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Valipour A; Karl-Landsteiner-Institute for Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna, Austria., Roux PP; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, QC, Canada.; Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada., Reimand J; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Jackson HW; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. schramek@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. schramek@lunenfeld.ca.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 05; Vol. 14 (1), pp. 5404. Date of Electronic Publication: 2023 Sep 05.