Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Rouslan G, Efremov"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Deposition of amyloid-β (Aβ) peptides in the brain is a hallmark of Alzheimer’s disease. Aβs are generated through sequential proteolysis of the amyloid precursor protein by the γ-secretase complexes (GSECs). Aβ peptide length, modula
Externí odkaz:
https://doaj.org/article/b60258a011264014909f335bfc837955
Autor:
Alexander V. Shkumatov, Nicolas Aryanpour, Cédric A. Oger, Gérôme Goossens, Bernard F. Hallet, Rouslan G. Efremov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Here the structure of transposase from Tn3 family is reported in apo form and bound to the transposon ends. The activation of the transposase induces metamorphic refolding of the catalytic domain suggesting the family-specific regulation mechanism.
Externí odkaz:
https://doaj.org/article/5b10e36e345447bc8671792a58e3030b
Autor:
Steven De Gieter, Casey I Gallagher, Eveline Wijckmans, Diletta Pasini, Chris Ulens, Rouslan G Efremov
Publikováno v:
eLife, Vol 12 (2023)
Cys-loop receptors or pentameric ligand-gated ion channels are mediators of electrochemical signaling throughout the animal kingdom. Because of their critical function in neurotransmission and high potential as drug targets, Cys-loop receptors from h
Externí odkaz:
https://doaj.org/article/cb456e98491945be9edc90399c12c86b
Publikováno v:
IUCrJ, Vol 7, Iss 4, Pp 707-718 (2020)
Single-particle cryo-EM has become an indispensable structural biology method. It requires regular access to high-resolution electron cryogenic microscopes. To fully utilize the capacity of the expensive high-resolution instruments, the time used for
Externí odkaz:
https://doaj.org/article/bf7a7f27ac3148f099068e5475a36687
Autor:
Piotr Kolata, Rouslan G Efremov
Publikováno v:
eLife, Vol 10 (2021)
Respiratory complex I is a multi-subunit membrane protein complex that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation against transmembrane potential. Complex I from Escherichia coli is among the best functionall
Externí odkaz:
https://doaj.org/article/108331eaea3f487dab33e088bc83796e
Autor:
Maricruz Fernandez, Alexander V Shkumatov, Yun Liu, Claire Stulemeijer, Sylvie Derclaye, Rouslan G Efremov, Bernard Hallet, David Alsteens
Publikováno v:
Nucleic acids research, Vol. 51, no.10, p. 4929-4941 (2023)
Transposon Tn4430 belongs to a widespread family of bacterial transposons, the Tn3 family, which plays a prevalent role in the dissemination of antibiotic resistance among pathogens. Despite recent data on the structural architecture of the transposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f896030f0618693758e6f7a2cfdf8b57
https://hdl.handle.net/2078.1/275713
https://hdl.handle.net/2078.1/275713
Publikováno v:
bioRxiv
Using single particle cryogenic electron microscopy (cryo-EM) high-resolution structures of proteins in different conformations can be reconstructed. Protein function often involves transient functional conformations, which can be resolved using time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9132e810ae2288f238f2c6c868311e03
https://doi.org/10.1101/2022.10.21.513149
https://doi.org/10.1101/2022.10.21.513149
Publikováno v:
IUCrJ
IUCrJ, Vol 7, Iss 4, Pp 707-718 (2020)
IUCrJ, Vol 7, Iss 4, Pp 707-718 (2020)
This paper presents a detailed assessment of the performance of the CRYO ARM 300 electron microscope in a multiuser cryo-EM facility setting. It is shown that the microscope can be used for reliable automated data collection. The strengths and weakne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c155c7ee6ef856c4baa1cb4be694c3
http://europepmc.org/articles/PMC7340256
http://europepmc.org/articles/PMC7340256
Autor:
Alexander V. Shkumatov, Nicolas Aryanpour, Cédric A. Oger, Gérôme Goossens, Bernard F. Hallet, Rouslan G. Efremov
Transposons account for a remarkable diversity of mobile genetic elements that play the role of genome architects in all domains of life. Tn3 is a family of widespread and among first identified bacterial transposons notorious for their contribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ea53466a08ee4faff640c6367b0e498
https://doi.org/10.1101/2022.02.23.481423
https://doi.org/10.1101/2022.02.23.481423