Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells.

Autor: Chokshi CR; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Shaikh MV; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Brakel B; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Rossotti MA; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, Ottawa, ON, Canada., Tieu D; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Maich W; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Anand A; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Chafe SC; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Zhai K; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Suk Y; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Kieliszek AM; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Miletic P; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Mikolajewicz N; Program for Genetics and Genome Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Toronto, ON, Canada., Chen D; Program for Genetics and Genome Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Toronto, ON, Canada., McNicol JD; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada., Chan K; Program for Genetics and Genome Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Toronto, ON, Canada., Tong AHY; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Kuhlmann L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Liu L; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Alizada Z; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Mobilio D; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Tatari N; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Savage N; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Aghaei N; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Grewal S; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Puri A; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Subapanditha M; Department of Medicine, McMaster University, Hamilton, ON, Canada., McKenna D; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Ignatchenko V; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Salamoun JM; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA., Kwiecien JM; Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Wipf P; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA., Sharlow ER; Department of Pharmacology, Fiske Drug Discovery Laboratory, University of Virginia, Charlottesville, VA, USA., Provias JP; Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Lu JQ; Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Lazo JS; Department of Pharmacology, Fiske Drug Discovery Laboratory, University of Virginia, Charlottesville, VA, USA., Kislinger T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Lu Y; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Brown KR; Program for Genetics and Genome Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Toronto, ON, Canada., Venugopal C; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Henry KA; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Moffat J; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. jason.moffat@sickkids.ca.; Program for Genetics and Genome Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Toronto, ON, Canada. jason.moffat@sickkids.ca.; Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada. jason.moffat@sickkids.ca., Singh SK; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.

Publikováno v: Nature medicine [Nat Med] 2024 Oct; Vol. 30 (10), pp. 2936-2946. Date of Electronic Publication: 2024 Aug 02.

The molecular mechanism responsible for HbSC retinopathy may depend on the action of the angiogenesis-related genes ROBO1 and SLC38A5 .

Autor: da Silva Costa SM; Center for Molecular Biology and Genetic Engineering, State University of Campinas-UNICAMP, Campinas, Brazil., Ito MT; Center for Molecular Biology and Genetic Engineering, State University of Campinas-UNICAMP, Campinas, Brazil., da Cruz PRS; Center for Molecular Biology and Genetic Engineering, State University of Campinas-UNICAMP, Campinas, Brazil., De Souza BB; Center for Molecular Biology and Genetic Engineering, State University of Campinas-UNICAMP, Campinas, Brazil., Rios VM; Center for Molecular Biology and Genetic Engineering, State University of Campinas-UNICAMP, Campinas, Brazil., Bertozzo VHE; Center for Molecular Biology and Genetic Engineering, State University of Campinas-UNICAMP, Campinas, Brazil., Camargo ACL; Center for Molecular Biology and Genetic Engineering, State University of Campinas-UNICAMP, Campinas, Brazil., Viturino MGM; Center for Molecular Biology and Genetic Engineering, State University of Campinas-UNICAMP, Campinas, Brazil., Lanaro C; Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas-UNICAMP, Campinas, Brazil., de Albuquerque DM; Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas-UNICAMP, Campinas, Brazil., do Canto AM; Departamento de Medicina Translacional, Faculdade de Ciências Médicas, Universidade Estadual de Campinas-UNICAMP, Campinas, Brazil., Saad STO; Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas-UNICAMP, Campinas, Brazil., Ospina-Prieto S; Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas-UNICAMP, Campinas, Brazil., Ozelo MC; Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas-UNICAMP, Campinas, Brazil., Costa FF; Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas-UNICAMP, Campinas, Brazil., de Melo MB; Center for Molecular Biology and Genetic Engineering, State University of Campinas-UNICAMP, Campinas, Brazil.

Publikováno v: Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2024 Jul 24; Vol. 249, pp. 10070. Date of Electronic Publication: 2024 Jul 24 (Print Publication: 2024).

The Role of SLIT3-ROBO4 Signaling in Endoplasmic Reticulum Stress-Induced Delayed Corneal Epithelial and Nerve Regeneration.

Autor: Chen R; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China., Wang Y; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China., Zhang Z; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China., Wang X; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China., Li Y; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China., Wang M; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China., Wang H; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China., Dong M; Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, China., Zhou Q; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China., Yang L; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China.

Publikováno v: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2024 May 01; Vol. 65 (5), pp. 8.

Cancer Cell-Type-Dependent Modifications of Metastatic Parameters by SLIT2-ROBO1 and RHOA cAMP Signaling in Response to TGFβ1 and FGF2.

Autor: Amjad Q; School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan; Cancer Research Centre, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan., Stein GS; Department of Biochemistry, University of Vermont Larner College of Medicine, Burlington, VT 05405; University of Vermont Cancer Center, University of Vermont Larner College of Medicine, Burlington, VT 05405., van Wijnen AJ; Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA., Shakoori AR; School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan; Cancer Research Center, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan.

Publikováno v: Critical reviews in eukaryotic gene expression [Crit Rev Eukaryot Gene Expr] 2024; Vol. 34 (7), pp. 35-49.

Magnetic nanomagnetic nanoparticles combining with Slit2 gene and bone marrow mononuclear cells to improve cognitive dysfunction in rats with chronic cerebral ischemia.

Autor: Wang N; Department of Neurology Inspection, The First Affiliated Hospital of China Medical University, No. 155 Nanjing Street, Shenyang, Liaoning Province, 110016, China., Lin M; Department of Neurology Inspection, The People's Hospital of Liaoning Province, No. 33 wenyi Road, Shenyang, Liaoning Province, 110016, China., Guo W; Department of Neurology Inspection, The People's Hospital of Liaoning Province, No. 33 wenyi Road, Shenyang, Liaoning Province, 110016, China., Cao Y; Department of Neurology Inspection, The First Affiliated Hospital of China Medical University, No. 155 Nanjing Street, Shenyang, Liaoning Province, 110016, China.; Department of Neurology Inspection, The People's Hospital of Liaoning Province, No. 33 wenyi Road, Shenyang, Liaoning Province, 110016, China.

Publikováno v: International journal of medical sciences [Int J Med Sci] 2024 Aug 19; Vol. 21 (11), pp. 2233-2243. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024).