Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Roumen Nikolaev Radinov"'
Autor:
Lianhe Shu, Lady Mae Alabanza, James A. Wright, Yan Dong, Ping Wang, Roumen Nikolaev Radinov, Romyr Dominique
Publikováno v:
Organic Process Research & Development. 17:114-119
An improved, kilogram-scale synthesis of a LTB4 receptor antagonist is reported. The title compound was prepared in four linear steps (seven steps total) and 54% overall yield. The 3,5-bisarylphenol core was obtained in nearly quantitative yield by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a25f55451f22ebbeed850dfd393b45b
https://doi.org/10.1021/op300302s
https://doi.org/10.1021/op300302s
Autor:
Robert Francis Kester, Linda Marcus, Marek M. Kabat, Lida Qi, Wang Ka, Michael Pignatello, Wendy Lea Corbett, Cheryl Spence, Franz M. Matschinsky, Lisa M. Garofalo, Roumen Nikolaev Radinov, Ramakanth Sarabu, David J Moore, Yi Ren, Nancy-Ellen Haynes, Zhenmin Liang, Fred Thomas Bizzarro, Darryl W. Hilliard, John Tengi, Wanping Geng, Stanley D. Hutchings, Thomas G. Steele, Joseph Grimsby, Mark T. Dvorozniak, Joseph F. Grippo, Kevin Richard Guertin, Paige Erin Mahaney, Jagdish Kumar Racha
Publikováno v:
Journal of Medicinal Chemistry. 55:7021-7036
Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we have previously disclosed, caused reversible hepatic lipidosis in repeat-dose toxicology stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aaa5f9f792871c6acf6b9f50fdaa356
https://doi.org/10.1021/jm3008689
https://doi.org/10.1021/jm3008689
Autor:
Roumen Nikolaev Radinov, Andrzej R. Daniewski, Wen Liu, Masami Okabe, Marek M. Kabat, Lisa M. Garofalo, Stanley D. Hutchings, George P. Yiannikouros
Publikováno v:
The Journal of Organic Chemistry. 67:1580-1587
The 1 alpha-hydroxy A-ring phosphine oxide 1, a useful building block for vitamin D analogues, was synthesized from (S)-carvone in nine synthetic operations and a single chromatographic purification in 25% overall yield. The synthesis features two no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fe5c5a814750195adfbe4deb688263
https://doi.org/10.1021/jo0161577
https://doi.org/10.1021/jo0161577
Publikováno v:
Tetrahedron Letters. 40:8955-8960
Selective palladium-catalyzed hydrogenolysis of propargylic alcohol 9, via its formate 10 or carbonate 13, gave up to 98% of alkyne 11. Alkyne allene selectivity is controlled by the steric bulk of the phosphine ligand, as well as the propargylic (C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c6c8444885eb4f84445759646cb304
https://doi.org/10.1016/s0040-4039(99)01941-3
https://doi.org/10.1016/s0040-4039(99)01941-3
Autor:
Joseph Grimsby, Wanping Geng, Navita L. Mallalieu, Mark T. Dvorozniak, Wendy Lea Corbett, Nancy-Ellen Haynes, Jagdish Kumar Racha, Yimin Qian, David J Moore, Kevin Richard Guertin, Nathan Robert Scott, Robert Francis Kester, Steven Joseph Berthel, Roumen Nikolaev Radinov, Francis A. Mennona, Ramakanth Sarabu, Duk Soon Choi, Paul Gillespie
Publikováno v:
ACS medicinal chemistry letters. 4(4)
To resolve the metabolite redox cycling associated with our earlier clinical compound 2, we carried out lead optimization of lead molecule 1. Compound 4 showed improved lipophilic ligand efficiency and demonstrated robust glucose lowering in diet-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20e248f7efd97a421037b2e0fbfb3ba
https://pubmed.ncbi.nlm.nih.gov/24900686
https://pubmed.ncbi.nlm.nih.gov/24900686
Publikováno v:
ChemInform. 30
The Red-Al ® reduction of 4-silyloxy propargylic alcohols to 4-silyloxy allylic alcohols involves two consecutive regio- and stereospecific 1,3 silyl migrations — from oxygen to carbon and then back to the original oxygen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a2fef48f365617c7304a150f3b7ab0
https://doi.org/10.1002/chin.199911081
https://doi.org/10.1002/chin.199911081
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a01418c93b0e876f2d79423e4d82d26
https://doi.org/10.1002/chin.200219298
https://doi.org/10.1002/chin.200219298
Autor:
George P. Yiannikouros, Roumen Nikolaev Radinov, Lisa M. Garofalo, Stanley D. Hutchings, Wen Liu, Masami Okabe, Marek M. Kabat, Andrzej R. Daniewski
Publikováno v:
ChemInform. 33
The 1α-hydroxy A-ring phosphine oxide 1, a useful building block for vitamin D analogues, was synthesized from (S)-carvone in nine synthetic operations and a single chromatographic purification in 25% overall yield. The synthesis features two novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4f58eabd7f3c511ed9d60398d28e438
https://doi.org/10.1002/chin.200231191
https://doi.org/10.1002/chin.200231191
Autor:
Wen Liu, Masami Okabe, Marek M. Kabat, Lisa M. Garofalo, Yuefen Zhou, Roumen Nikolaev Radinov, Andrzej R. Daniewski, Stanley D. Hutchings
Publikováno v:
The Journal of organic chemistry. 66(18)
The 1alpha-fluoro A-ring phosphine oxide 1, a useful building block for fluorinated vitamin D analogues, was synthesized from (S)-carvone in 13 synthetic steps, and only five isolations, in 22% overall yield. In the key synthetic step, a highly selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dc1d7690802b0b946e07dc7c24c17d
https://pubmed.ncbi.nlm.nih.gov/11529743
https://pubmed.ncbi.nlm.nih.gov/11529743
Publikováno v:
Helvetica Chimica Acta, Vol. 75, No 1 (1992) pp. 170-173
Hydroboration of aliphatic 1-alkynes with freshly prepared dicyclohexylborane (1 mol-equiv., hexane), treatment of the resulting [(E)-1-alkenyl]boranes 5 with Et2Zn or Me2Zn (1.05 mol-equiv.) followed by addition of (−)-3-exo-(dimethylamino)isoborn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e5b7d7c0cdd388ac44a50fcddcd304
https://archive-ouverte.unige.ch/unige:85071
https://archive-ouverte.unige.ch/unige:85071
