Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of π*–π* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT 1 non-peptide antagonists

Autor: Polevaya, Ludmila, Mavromoustakos, Thomas, Zoumboulakis, Panagiotis, Grdadolnik, Simona Golic, Roumelioti, Panagiota, Giatas, Nektarios, Mutule, Ilze, Keivish, Tatjana, Vlahakos, Demetrios V, Iliodromitis, Efstathios K, Kremastinos, Dimitrios Th, Matsoukas, John

Publikováno v: In Bioorganic & Medicinal Chemistry 2001 9(6):1639-1647

An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT1 Angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies.

Autor: Agelis, George¹ aggelisgeorge@hotmail.com, Roumelioti, Panagiota¹, Resvani, Amalia¹, Durdagi, Serdar², Androutsou, Maria-Eleni¹, Kelaidonis, Konstantinos¹, Vlahakos, Demetrios³, Mavromoustakos, Thomas⁴, Matsoukas, John^1,5 eldrug@eldrug.gr

Publikováno v: Journal of Computer-Aided Molecular Design. Sep2010, Vol. 24 Issue 9, p749-758. 10p. 2 Color Photographs, 3 Diagrams, 1 Chart, 1 Graph.

Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-Chain bridges: Role of C-Terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists

Autor: Roumelioti, Panagiota¹, Polevaya, Ludmila², Zoumpoulakis, Panagiotis³, Giatas, Nektarios¹, Mutule, Ilze², Keivish, Tatjana², Zoga, Anastasia³, Vlahakos, Demetrios⁴, Iliodromitis, E.⁴, Kremastinos, Demetrios⁴, Grdadolnik, Simona Golic⁵, Mavromoustakos, Thomas² tmavro@eie.gr, Matsoukas, John¹

Publikováno v: Bioorganic & Medicinal Chemistry Letters. Sep2002, Vol. 12 Issue 18, p2627. 7p.

Σχεδιασμός και σύνθεση μη πεπτιδικών μιμητών της αγγειοτασίνης II με αντιυπερτασική δράση

Autor: Ματσούκας, Ιωάννης, Roumelioti, Panagiota, Παπαιωάννου, Διονύσιος, Βλαχάκος, Δημήτριος, Τσεγενίδης, Θεόδωρος, Σταυρόπουλος, Γεώργιος, Πούλος, Κωνσταντίνος, Γάτος, Δημήτριος

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http://nemertes.lis.upatras.gr/jspui/handle/10889/2253