Early effects of androgen deprivation on bone and mineral homeostasis: A prospective cohort study

Autor: Rougin Khalil, Leen Antonio, Michaël R. Laurent, Karel David, Na Ri Kim, Pieter Evenepoel, Anton Eisenhauer, Alexander Heuser, Etienne Cavalier, Sundeep Khosla, Frank Claessens, Dirk Vanderschueren, Brigitte Decallonne

Publikováno v: Bone Reports, Vol 13, Iss , Pp 100342- (2020)

Externí odkaz: https://doaj.org/article/3db22d7db6bb477491b36f80145e090f

Testosterone reduces body fat in male mice by stimulation of physical activity via extrahypothalamic ER alpha signaling

Autor: Jan-Åke Gustafsson, Vanessa Dubois, Brigitte Decallonne, Claes Ohlsson, Leen Antonio, Ludo Deboel, Karel David, Na Ri Kim, Dirk Vanderschueren, Katrien Corbeels, Frank Claessens, Bart Van der Schueren, Rougin Khalil, Dieter Schollaert, Roman Vangoitsenhoven

Publikováno v: ENDOCRINOLOGY
Endocrinology

Testosterone (T) reduces male fat mass, but the underlying mechanisms remain elusive, limiting its clinical relevance in hypogonadism-associated obesity. Here, we subjected chemically castrated high-fat diet-induced adult obese male mice to supplemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b231b5ac2dd4ab233fda2d0b3fa833
https://biblio.ugent.be/publication/8737850

Therapy-Resistant Hypercalcemia in a Patient with InactivatingCYP24A1Mutation and Recurrent Nephrolithiasis: Beware of Concomitant Hyperparathyroidism

Autor: Pieter Evenepoel, H Hannon, Rougin Khalil, Brigitte Decallonne, Karel David

We describe a case harboring a homozygous CYP24A1 mutation with mild loss of function, first presenting with recurrent nephrolithiasis from the age of 22 onward, initially associated with hypercalcemia and low PTH concentrations. Over the years, hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6a528d4b76bb6917f76dbc3adaae77
https://lirias.kuleuven.be/handle/123456789/658117

Androgen action on renal calcium and phosphate handling: Effects of bisphosphonate treatment and low calcium diet

Autor: Brigitte Decallonne, Dieter Schollaert, Philippa T. K. Saunders, Dirk Vanderschueren, Rougin Khalil, Geert Carmeliet, Ioannis Simitsidellis, Na Ri Kim, Ludo Deboel, Ferran Jardi, Frank Claessens

Publikováno v: Khalil, R, Simitsidellis, I, Kim, N R, Jardi, F, Schollaert, D, Deboel, L, Saunders, P, Carmeliet, G, Claessens, F, Vanderschueren, D & Decallonne, B 2020, ' Androgen action on renal calcium and phosphate handling: Effects of bisphosphonate treatment and low calcium diet ', Molecular and Cellular Endocrinology, vol. 514, pp. 110891 . https://doi.org/10.1016/j.mce.2020.110891

Renal calcium and phosphate handling is an important contributor to mineral homeostasis and bone health and the androgen receptor (AR) is highly expressed in the kidney. We investigated the short term effects of androgen deprivation on renal calcium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea12832cdfd02fb8b03ec113341d794
https://hdl.handle.net/20.500.11820/c21f615c-d9af-414e-b8c7-f0f0997c0f77

Sex steroids and the kidney: role in renal calcium and phosphate handling

Autor: Dirk Vanderschueren, Brigitte Decallonne, Ferran Jardi, Na Ri Kim, Frank Claessens, Rougin Khalil

Publikováno v: Molecular and Cellular Endocrinology. 465:61-72

Calcium and phosphate are vital for the organism and constitute essential components of the skeleton. Serum levels are tightly hormonally regulated and maintained by exchange with three major sources: the intestines, the kidney and the bone. The effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6ce4e5a032e8dc9de95491186eea67
https://doi.org/10.1016/j.mce.2017.11.011