The timeline of epigenetic drug discovery: from reality to dreams

Autor: Ganesan, A, Arimondo, PB, Rots, MG, Jeronimo, C, Berdasco, M

Publikováno v: Clinical Epigenetics
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)

The flexibility of the epigenome has generated an enticing argument to explore its reversion through pharmacological treatments as a strategy to ameliorate disease phenotypes. All three families of epigenetic proteins-readers, writers, and erasers-ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8034c7b015eba51c7ae6cc87d465986b
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1305

A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity

Autor: Kirby, TO, Rivera, A, Rein, D, Ulasov, [No Value], Breidenbach, M, Kataram, M, Contreras, JL, Krumdieck, C, Yamamoto, M, Rots, MG, Haisma, HJ, Alvarez, RD, Mahasreshti, PJ, Curiel, DT

Publikováno v: Clin.Cancer Res., 10(24), 8697-8703. AMER ASSOC CANCER RESEARCH

Purpose: Current animal tumor models are inadequate for the evaluation of toxicity and efficacy of conditionally replicative adenoviruses. A novel model system is needed that will provide insight into the anticipated therapeutic index of conditionall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::c5a52b312b327a03f1a908dbc4a68c1b
https://research.rug.nl/en/publications/b61a0854-fffb-4d98-b08e-8dba147b877c

Different drug sensisivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down

Autor: Zwaan, CM, Kaspers, GJL, Pieters, Rob, Hählen, K, Janka-Schaub, GE, van Zantwijk, CH, Huismans, DR, Vries, Esther, Rots, MG, Peters, GJ, Jansen, G, Creutzig, U, Veerman, AJP

Publikováno v: Blood, 99, 3352-3360. American Society of Hematology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::2dfd7a6a004eac60b8551d503ab6f44c
https://pure.eur.nl/en/publications/a6bdb330-a28e-4ffa-91d8-64c14f58d48b

In vitro drug resistance and prognostic impact of p16-INK4a/P15-INK4b deletions in childhood T-cell acute lymphoblastic leukaemia

Autor: Ramakers-van Woerden, NL, Pieters, R, Slater, RM, Loonen, A.H., Beverloo, HB, van Drunen, E, Heyman, M, Moreno, TC, Rots, MG, van Wering, ER, Kamps, WA, Janka-Schaub, GE, Veerman, AJP

Publikováno v: British Journal of Haematology, 112, 680-690. Wiley-Blackwell Publishing Ltd
British Journal of Haematology, 112(3), 680-690. Wiley

p16 gene deletions are present in about 70% of primary paediatric T-cell acute lymphoblastic leukaemia (T-ALL) and 20% of common/precursor B-cell ALL cases. It is not clear what the impact of the frequent p16 deletions is within the subgroup of T-lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::15a2d7e918e63a6678e89bbe42477fe5
https://pure.eur.nl/en/publications/23b9fb86-e71d-470d-844e-0ec0a3f7466f

Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia

Autor: Rots, MG, Pieters, Rob, Peters, GJ, Noordhuis, P, van Zantwijk, CH, Henze, G, Janka-Schaub, GE, Veerman, AJP, Jansen, G

Publikováno v: British Journal of Haematology, 109(3), 629-34. Wiley-Blackwell
Rots, M G, Pieters, R, Peters, G J, Noordhuis, P, Van Zantwijk, C H, Henze, G, Janka-Schaub, G E, Veerman, A J & Jansen, G 2000, ' Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia ', British Journal of Haematology, vol. 109, no. 3, pp. 629-34 .
British Journal of Haematology, 109, 629-634. Wiley-Blackwell Publishing Ltd

Treatment failure in childhood acute lymphoblastic leukaemia (ALL) might be associated with methotrexate (MTX) resistance. Little is known about MTX resistance in relapsed ALL. In this study, we determined ex vivo MTX resistance in precursor-B ALL at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::776c41a606705efc7392a13f6bd5b78b
https://research.vumc.nl/en/publications/cfd0824f-7e9a-4e5f-960b-6a4aa67851cd