B-cell-specific checkpoint molecules that regulate anti-tumour immunity.

Autor: Bod L; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kye YC; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Shi J; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; BeiGene, Beijing, China., Torlai Triglia E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schnell A; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Fessler J; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Division of Immunology and Pathophysiology, Medical University of Graz, Graz, Austria., Ostrowski SM; Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA., Von-Franque MY; Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA., Kuchroo JR; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA., Barilla RM; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Zaghouani S; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Christian E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Delorey TM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mohib K; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Xiao S; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Slingerland N; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Giuliano CJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Li Z; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rothstein DM; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Fisher DE; Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Department of Biology and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Sharpe AH; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA., Quintana FJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Department of Biology and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Apetoh L; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; INSERM, Tours, France.; Faculté de Médecine, Université de Tours, Tours, France., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Howard Hughes Medical Institute, Department of Biology and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, San Francisco, CA, USA. aviv.regev.sc@gmail.com., Kuchroo VK; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. vkuchroo@rics.bwh.harvard.edu.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. vkuchroo@rics.bwh.harvard.edu.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. vkuchroo@rics.bwh.harvard.edu.

Publikováno v: Nature [Nature] 2023 Jul; Vol. 619 (7969), pp. 348-356. Date of Electronic Publication: 2023 Jun 21.

Characterization and Activity of TIM-1 and IL-10-Reporter Expressing Regulatory B Cells.

Autor: Mohib K; Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rothstein DM; Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Ding Q; Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dingq@upmc.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 179-202.

B Cell IL-4 Drives Th2 Responses In Vivo , Ameliorates Allograft Rejection, and Promotes Allergic Airway Disease.

Autor: Song Z; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.; School of Medicine, Tsinghua University, Beijing, China., Yuan W; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.; Department of Kidney Transplantation and Department of Organ Transplantation and General Surgery, Second Xiangya Hospital of Central South University, Changsha, China., Zheng L; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.; Department of Rheumatology and Clinical Immunology, First Affiliated Hospital of Guangxi Medical University, Nanning, China., Wang X; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, United States., Kuchroo VK; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, United States.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, United States., Mohib K; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Rothstein DM; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Mar 14; Vol. 13, pp. 762390. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022).

The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections.

Autor: Modi G; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Marqus GM; Graduate Program in Chemistry, Brandeis University, Waltham Massachusetts 02453, United States., Vippila MR; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health Building 2, 4849 Calhoun Rd., Houston, Texas 77204, United States., Gollapalli DR; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Kim Y; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States.; The Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States., Manna AC; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, United States., Chacko S; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Maltseva N; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States.; The Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States., Wang X; Graduate Program in Chemistry, Brandeis University, Waltham Massachusetts 02453, United States., Cullinane RT; Department of Biochemistry, Brandeis University, Massachusetts 02453, United States., Zhang Y; Department of Biochemistry, Brandeis University, Massachusetts 02453, United States., Kotler JLM; Graduate Program in Biochemistry and Biophysics, Brandeis University, Waltham, Massachusetts 02453, United States., Kuzmic P; BioKin Ltd., Watertown, Massachusetts 02472, United States., Zhang M; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Lawson AP; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Joachimiak A; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States.; The Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60367, United States., Cheung A; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, United States., Snider BB; Department of Chemistry, Brandeis University, Waltham, Massachusetts 02453, United States., Rothstein DM; David Rothstein Consulting, LLC, Lexington, Massachusetts 02421, United States., Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health Building 2, 4849 Calhoun Rd., Houston, Texas 77204, United States., Hedstrom L; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States.; Department of Chemistry, Brandeis University, Waltham, Massachusetts 02453, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2021 Nov 12; Vol. 7 (11), pp. 3062-3076. Date of Electronic Publication: 2021 Sep 30.

Transitional B cell cytokines predict renal allograft outcomes.

Autor: Cherukuri A; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Salama AD; University College of London Department of Renal Medicine, Royal Free Hospital, London NW3 2QG, UK., Mehta R; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Mohib K; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA., Zheng L; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Rheumatology and Immunology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China., Magee C; University College of London Department of Renal Medicine, Royal Free Hospital, London NW3 2QG, UK., Harber M; University College of London Department of Renal Medicine, Royal Free Hospital, London NW3 2QG, UK., Stauss H; UCL Institute of Immunity and Transplantation, Royal Free Hospital, London NW3 2QG, UK., Baker RJ; Renal Unit, St. James's University Hospital, Leeds LS9 7TF, UK., Tevar A; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA., Landsittel D; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15206, USA., Lakkis FG; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Hariharan S; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Rothstein DM; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA. rothsteind@upmc.edu.; Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Feb 24; Vol. 13 (582).