A family of NADPH/NADP ⁺ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes.

Autor: Scherschel M; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany., Niemeier JO; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, Münster, Germany., Jacobs LJHC; Redox Metabolism, Institute for Biochemistry, University of Cologne, Cologne, Germany., Hoffmann MDA; Department of Biophysics, Center for Human and Molecular Biology (ZHMB), Saarland University, Homburg, Germany., Diederich A; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany., Bell C; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, Münster, Germany., Höhne P; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany.; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, Münster, Germany., Raetz S; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, Münster, Germany., Kroll JB; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, Münster, Germany., Steinbeck J; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, Münster, Germany., Lichtenauer S; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, Münster, Germany., Multhoff J; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, Münster, Germany., Zimmermann J; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany., Sadhanasatish T; Institute of Integrative Cell Biology and Physiology, University of Münster, Schlossplatz 5, Münster, Germany., Rothemann RA; Redox Metabolism, Institute for Biochemistry, University of Cologne, Cologne, Germany., Grashoff C; Institute of Integrative Cell Biology and Physiology, University of Münster, Schlossplatz 5, Münster, Germany., Messens J; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, Brussels, Belgium.; Brussels Center for Redox Biology, Vrije Universiteit Brussel, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium., Ampofo E; Institute for Clinical & Experimental Surgery, Saarland University, Homburg, Germany., Laschke MW; Institute for Clinical & Experimental Surgery, Saarland University, Homburg, Germany., Riemer J; Redox Metabolism, Institute for Biochemistry, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany., Roma LP; Department of Biophysics, Center for Human and Molecular Biology (ZHMB), Saarland University, Homburg, Germany., Schwarzländer M; Institute of Plant Biology and Biotechnology, University of Münster, Schlossplatz 8, Münster, Germany. markus.schwarzlander@uni-muenster.de., Morgan B; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany. bruce.morgan@uni-saarland.de.

Publikováno v: Nature communications [Nat Commun] 2024 Dec 19; Vol. 15 (1), pp. 10704. Date of Electronic Publication: 2024 Dec 19.

AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5.

Autor: Salscheider SL; Institute for Biochemistry, University of Cologne, Cologne, Germany., Gerlich S; Institute for Biochemistry, University of Cologne, Cologne, Germany., Cabrera-Orefice A; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Peker E; Institute for Biochemistry, University of Cologne, Cologne, Germany., Rothemann RA; Institute for Biochemistry, University of Cologne, Cologne, Germany., Murschall LM; Institute for Biochemistry, University of Cologne, Cologne, Germany., Finger Y; Institute for Biochemistry, University of Cologne, Cologne, Germany., Szczepanowska K; Medical Faculty, Institute for Mitochondrial Diseases and Aging, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Ahmadi ZA; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Guerrero-Castillo S; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Erdogan A; Institute for Biochemistry, University of Cologne, Cologne, Germany., Becker M; Institute for Biochemistry, University of Cologne, Cologne, Germany., Ali M; Institute for Biochemistry, University of Cologne, Cologne, Germany., Habich M; Institute for Biochemistry, University of Cologne, Cologne, Germany., Petrungaro C; Institute for Biochemistry, University of Cologne, Cologne, Germany., Burdina N; Institute for Biochemistry, University of Cologne, Cologne, Germany., Schwarz G; Institute for Biochemistry, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine, University of Cologne, Cologne, Germany., Klußmann M; Institute for Biochemistry, University of Cologne, Cologne, Germany., Neundorf I; Institute for Biochemistry, University of Cologne, Cologne, Germany., Stroud DA; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Vic., Australia., Ryan MT; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Vic., Australia., Trifunovic A; Medical Faculty, Institute for Mitochondrial Diseases and Aging, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine, University of Cologne, Cologne, Germany., Brandt U; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Riemer J; Institute for Biochemistry, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Publikováno v: The EMBO journal [EMBO J] 2022 Sep 01; Vol. 41 (17), pp. e110784. Date of Electronic Publication: 2022 Jul 20.