Quantitative prediction of long-term molecular response in TKI-treated CML – Lessons from an imatinib versus dasatinib comparison

Autor: Glauche, Ingmar, Kuhn, Matthias, Baldow, Christoph, Schulze, Philipp, Rothe, Tino, Liebscher, Hendrik, Roy, Amit, Wang, Xiaoning, Roeder, Ingo

Longitudinal monitoring of BCR-ABL transcript levels in peripheral blood of CML patients treated with tyrosine kinase inhibitors (TKI) revealed a typical biphasic response. Although second generation TKIs like dasatinib proved more efficient in achie

Externí odkaz: https://tud.qucosa.de/id/qucosa%3A32495
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Anwendung mathematischer Modelle zur Vorhersage des Therapieverlaufs von CML-Patienten

Autor: Rothe, Tino

Hintergrund Die chronische myeloische Leukämie (CML) ist eine myeloproliferative Er- krankung, die aufgrund ihres Modellcharakters unter der Behandlung mit Tyrosin-Kinase- Inhibitoren (TKI) gut für eine Beschreibung mittels computerbasierter Modell

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https://tud.qucosa.de/id/qucosa:30685

Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison.

Autor: Glauche I; Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany., Kuhn M; Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany., Baldow C; Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany., Schulze P; Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany., Rothe T; Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany., Liebscher H; Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany., Roy A; Bristol-Myers Squibb, Lawrenceville, NJ, USA., Wang X; Bristol-Myers Squibb, Lawrenceville, NJ, USA., Roeder I; Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. ingo.roeder@tu-dresden.de.; National Center for Tumor Diseases (NCT) partner site Dresden, Dresden, Germany. ingo.roeder@tu-dresden.de.

Publikováno v: Scientific reports [Sci Rep] 2018 Aug 17; Vol. 8 (1), pp. 12330. Date of Electronic Publication: 2018 Aug 17.