The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells

Autor: Irwin, RE, Scullion, C, Thursby, SJ, Sun, M, Thakur, A, Hilman, L, Callaghan, B, Thompson, PD, McKenna, DJ, Rothbart, SB, Xu, Guoliang, Walsh, CP

Publikováno v: Epigenetics; December 2023, Vol. 18 Issue: 1

Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts.

Autor: Francois AK; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA., Rohani A; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA., Loftus M; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA., Dochnal S; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA., Hrit J; Department of Epigenetics, Van Andel Institute, Grand Rapids, USA., McFarlane S; MRC - University of Glasgow, Centre for Virus Research, Glasgow, United Kingdom., Whitford A; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA., Lewis A; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA., Krakowiak P; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA., Boutell C; MRC - University of Glasgow, Centre for Virus Research, Glasgow, United Kingdom., Rothbart SB; Department of Epigenetics, Van Andel Institute, Grand Rapids, USA., Kashatus D; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA., Cliffe AR; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.

Publikováno v: MBio [mBio] 2024 Apr 10; Vol. 15 (4), pp. e0327823. Date of Electronic Publication: 2024 Feb 27.

Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling.

Autor: Chomiak AA; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Tiedemann RL; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Liu Y; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Kong X; Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Cui Y; Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Wiseman AK; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Thurlow KE; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Cornett EM; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indiana University, Indianapolis, IN 46202, USA., Topper MJ; Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Baylin SB; Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Rothbart SB; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.

Publikováno v: Science advances [Sci Adv] 2024 Mar 29; Vol. 10 (13), pp. eadk4423. Date of Electronic Publication: 2024 Mar 27.

Lysine methylation signaling in skeletal muscle biology: from myogenesis to clinical insights.

Autor: Cordeiro-Spinetti E; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan 49503, U.S.A., Rothbart SB; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan 49503, U.S.A.

Publikováno v: The Biochemical journal [Biochem J] 2023 Dec 13; Vol. 480 (23), pp. 1969-1986.

Ketolysis drives CD8 ⁺ T cell effector function through effects on histone acetylation.

Autor: Luda KM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research, Blegdamsvej 3B, 2200 København, Denmark., Longo J; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Kitchen-Goosen SM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Duimstra LR; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Ma EH; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Watson MJ; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Oswald BM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Fu Z; Bioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA., Madaj Z; Bioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA., Kupai A; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Dickson BM; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., DeCamp LM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Dahabieh MS; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Compton SE; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Teis R; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Kaymak I; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Lau KH; Bioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA., Kelly DP; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Puchalska P; Department of Medicine, Division of Molecular Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Williams KS; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Krawczyk CM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Lévesque D; Department of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada., Boisvert FM; Department of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada., Sheldon RD; Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI 49503, USA., Rothbart SB; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Crawford PA; Department of Medicine, Division of Molecular Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Jones RG; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: russell.jones@vai.org.

Publikováno v: Immunity [Immunity] 2023 Sep 12; Vol. 56 (9), pp. 2021-2035.e8. Date of Electronic Publication: 2023 Jul 28.