Elevated A-to-I RNA editing in COVID-19 infected individuals.

Autor: Merdler-Rabinowicz R; Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel., Gorelik D; Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.; The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel., Park J; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA.; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Meydan C; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA., Foox J; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA., Karmon M; Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.; The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel., Roth HS; Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.; The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel., Cohen-Fultheim R; Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.; The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel., Shohat-Ophir G; Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.; Leslie and Susan Gonda Multidisciplinary Brain Research Center and The Nanotechnology Institute, Bar-Ilan University, Ramat Gan, Israel., Eisenberg E; Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel Aviv, Israel., Ruppin E; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Mason CE; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Levanon EY; Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.; The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel.

Publikováno v: NAR genomics and bioinformatics [NAR Genom Bioinform] 2023 Oct 18; Vol. 5 (4), pp. lqad092. Date of Electronic Publication: 2023 Oct 18 (Print Publication: 2023).

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients.

Autor: Joshi AD; Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Botham RC; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA., Schlein LJ; Department of Pathobiology, University of Illinois Urbana-Champaign, Urbana, IL, USA., Roth HS; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA., Mangraviti A; Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Borodovsky A; Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Tyler B; Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Joslyn S; VetCT Australia, Fremantle WA, Australia., Looper JS; Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, LA, USA., Podell M; Department of Neurology, MedVet Chicago, Chicago, IL, USA., Fan TM; Department of Veterinary Clinical Medicine, University of Illinois Urbana-Champaign, Urbana, IL, USA., Hergenrother PJ; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA., Riggins GJ; Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Publikováno v: Oncotarget [Oncotarget] 2017 Jul 07; Vol. 8 (46), pp. 80124-80138. Date of Electronic Publication: 2017 Jul 07 (Print Publication: 2017).

The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas.

Autor: Peh J; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois. Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois., Fan TM; Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois. Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois., Wycislo KL; Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois., Roth HS; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois. Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois., Hergenrother PJ; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois. Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois. hergenro@uiuc.edu.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2016 Aug; Vol. 15 (8), pp. 1859-69. Date of Electronic Publication: 2016 Jun 13.

Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics.

Autor: Roth HS; †Department of Chemistry, ‡Department of Veterinary Clinical Medicine, and §Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61801, United States., Botham RC; †Department of Chemistry, ‡Department of Veterinary Clinical Medicine, and §Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61801, United States., Schmid SC; †Department of Chemistry, ‡Department of Veterinary Clinical Medicine, and §Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61801, United States., Fan TM; †Department of Chemistry, ‡Department of Veterinary Clinical Medicine, and §Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61801, United States., Dirikolu L; †Department of Chemistry, ‡Department of Veterinary Clinical Medicine, and §Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61801, United States., Hergenrother PJ; †Department of Chemistry, ‡Department of Veterinary Clinical Medicine, and §Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61801, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 May 14; Vol. 58 (9), pp. 4046-65. Date of Electronic Publication: 2015 Apr 20.

Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1).

Autor: Hsu DC; Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, 61801, United States., Roth HS, West DC, Botham RC, Novotny CJ, Schmid SC, Hergenrother PJ

Publikováno v: ACS combinatorial science [ACS Comb Sci] 2012 Jan 09; Vol. 14 (1), pp. 44-50. Date of Electronic Publication: 2011 Oct 28.