Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Roth, B. L."'
Autor:
Gray, J. A.1 john.gray@ucsf.edu, Roth, B. L.2
Publikováno v:
Molecular Psychiatry. Oct2007, Vol. 12 Issue 10, p904-922. 19p. 2 Diagrams, 3 Charts.
Neural function within the medial prefrontal cortex (mPFC) regulates normal cognition, attention and impulse control, implicating neuroregulatory abnormalities within this region in mental dysfunction related to schizophrenia, depression and drug abu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b41626e3f74cf57343ae0824f400dd7d
Autor:
DiBerto, J. F., Nichols, D. E., Robinson, J. E., Polepally, P. R., Roth, B. L., Zhu, H., Zjawiony, J. K., White, K. L., Malanga, C. J.
The hypothesis that functionally selective G protein-coupled receptor (GPCR) agonists may have enhanced therapeutic benefits has revitalized interest for many GPCR targets. In particular, although κ-opioid receptor (KOR) agonists are analgesic with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23861283de9348467111da1f2491ad8
Autor:
Roth, B. L., Kenakin, T., White, K. L., Bikbulatov, R. V., Polepally, P. R., Scopton, A. P., Javitch, J. A., Zjawiony, J. K., Brown, P. J., Rives, M.-L.
The κ-opioid receptor (KOR)-dynorphin system has been implicated in the control of affect, cognition, and motivation, and is thought to be dysregulated in mood and psychotic disorders, as well as in various phases of opioid dependence. KOR agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f1f5efb86bf7353da5fee3a8ae30e29
Autor:
Cherezov, V., Katritch, V., Xu, H. E., Jiang, Y., Roth, B. L., Chu, M., Vardy, E., Huang, X.-P., McCorvy, J. D., Wang, C., Han, G. W., Liu, W., Wacker, D., Stevens, R. C., Siu, F. Y.
Drugs active at G protein-coupled receptors (GPCRs) can differentially modulate either canonical or non-canonical signaling pathways via a phenomenon known as functional selectivity or biased signaling. We report biochemical studies that show that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee3c0053647ca2ad58b494a1896d749d
Autor:
Roth, B. L., Irwin, J. J., Setola, V., Lounkine, E., Marnett, L., Crews, B. A., Shoichet, B. K., Hert, J., Gregori-Puigjane, E.
Notwithstanding their key roles in therapy and as biological probes, 7% of approved drugs are purported to have no known primary target, and up to 18% lack a well-defined mechanism of action. Using a chemoinformatics approach, we sought to “de-orph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478baaecb1e6373092407886edb1303c
Autor:
Roth, B. L., Rogan, S. C.
A significant challenge for neuroscientists is to determine how both electrical and chemical signals affect the activity of cells and circuits and how the nervous system subsequently translates that activity into behavior. Remote, bidirectional manip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::229ad237ade4f06f804bdcf5810ed154
Autor:
Setola, V., Jensen, N. H., Jin, J., Feng, B., Wetsel, W. C., Frye, S. V., Caron, M. G., Chen, M., Roth, B. L., Allen, J. A., Yadav, P. N., Bai, X., Sassano, M. F., Yost, J. M., Chen, X., Peterson, S., Javitch, J. A., Che, X., Huang, X.-p.
Elucidating the key signal transduction pathways essential for both antipsychotic efficacy and side-effect profiles is essential for developing safer and more effective therapies. Recent work has highlighted noncanonical modes of dopamine D2 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b00eae60d70e28b477b2c1c18804ba9c
Reported biological activities of Stemona natural products, such as antitussive activity, inspired the development of synthetic methods to access several alkaloids within this family and in so doing develop a general route to the core skeleta shared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f82984c5c82d32254e0397df671916d5
Dysregulation of the 5-HT2A receptor is implicated in both the etiology and treatment of schizophrenia. Although the essential role of 5-HT2A receptors in atypical antipsychotic drug actions is widely accepted, the contribution of 5-HT2A down-regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b443dfb652bdb40644ba8581c1293059