Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rotana Alsaggaf"'
Autor:
Youjin Wang, Ana Best, Roberto Fernández‐Torrón, Rotana Alsaggaf, Mikel Garcia‐Puga, Casey L. Dagnall, Belynda Hicks, Mone’t Thompson, Ander Matheu Fernandez, Miren Zulaica Ijurco, Mark H. Greene, Adolfo Lopez de Munain, Shahinaz M. Gadalla
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 1, Pp 126-131 (2020)
Abstract Myotonic dystrophy type I (DM1) is an autosomal dominant disease of which clinical manifestations resemble premature aging. We evaluated the contribution of telomere length in pathogenesis in 361 DM1 patients (12 with serial measurements) an
Externí odkaz:
https://doaj.org/article/ab1fd0fbd9f647a7918fddbaf4a84c8d
Autor:
Rotana Alsaggaf, Diane Marie M. St. George, Min Zhan, Ruth M. Pfeiffer, Youjin Wang, Lesley A. Anderson, Zhiwei Liu, Jill Koshiol, Andrew J. Bauer, Kathryn R. Wagner, Mark H. Greene, Sania Amr, Shahinaz M. Gadalla
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1510-1518 (2019)
Abstract Objectives Recent evidence showed that myotonic dystrophy type I (DM1) patients are at increased risk of certain cancers, but the risk of benign tumors is unknown. We compared the risk of benign tumors in DM1 patients with matched DM1‐free
Externí odkaz:
https://doaj.org/article/affd1af81b8a43f989b4efc976de6621
Autor:
Cecilia Higgs, James E. Hilbert, Libby Wood, William B. Martens, Chiara Marini-Bettolo, Nikoletta Nikolenko, Rotana Alsaggaf, Hanns Lochmüller, Richard T. Moxley, Mark H. Greene, Youjin Wang, Shahinaz M. Gadalla
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Introduction: Recent evidence demonstrates that women with myotonic dystrophy type 1 are at increased risk of reproductive organ tumors. However, studies of reproductive cancer risk factors in those patients are lacking.Methods: Using questionnaires,
Externí odkaz:
https://doaj.org/article/016292eb1f6548edb64a433020606367
Autor:
Youjin Wang, Sharon A. Savage, Rotana Alsaggaf, Geraldine Aubert, Casey L. Dagnall, Stephen R. Spellman, Stephanie J. Lee, Belynda Hicks, Kristine Jones, Hormuzd A. Katki, Shahinaz M. Gadalla
Publikováno v:
Cells, Vol 7, Iss 11, p 183 (2018)
Telomere length (TL) comparisons from different methods are challenging due to differences in laboratory techniques and data configuration. This study aimed to assess the validity of converting the quantitative polymerase chain reaction (qPCR) telome
Externí odkaz:
https://doaj.org/article/b6244d9bded14b7483f6159a135e3aa3
Autor:
Rotana Alsaggaf, Sharon A. Savage, Shilpa Katta, Steve Horvath, Belynda Hicks, Emily E Pearce, Shahinaz M. Gadalla, Casey L. Dagnall, Hormuzd A. Katki, Stephen R. Spellman, Geraldine Aubert
Publikováno v:
Aging (Albany NY)
Telomere length (TL) is a marker of biological aging associated with several health outcomes. High throughput reproducible TL measurements are needed for large epidemiological studies. We compared the novel DNA methylation-based estimator (DNAmTL) wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe682be45a276a322996925a7b61d1b0
https://doi.org/10.18632/aging.203126
https://doi.org/10.18632/aging.203126
Autor:
Emily E. Pearce, Rotana Alsaggaf, Shilpa Katta, Casey Dagnall, Geraldine Aubert, Belynda D. Hicks, Stephen R. Spellman, Sharon A. Savage, Steve Horvath, Shahinaz M. Gadalla
Publikováno v:
GeroScience
Telomere length (TL) and DNA methylation–based epigenetic clocks are markers of biological age, but the relationship between the two is not fully understood. Here, we used multivariable regression models to evaluate the relationships between leukoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da7cec71a443b805e60669952f040bb
https://pubmed.ncbi.nlm.nih.gov/35585300
https://pubmed.ncbi.nlm.nih.gov/35585300
Autor:
Blanche P. Alter, Marena R. Niewisch, Sonia Bhala, Rotana Alsaggaf, Lisa J. McReynolds, Neelam Giri, Sharon A. Savage
Publikováno v:
Blood. 139(12)
Dyskeratosis congenita related telomere biology disorders (DC/TBDs) are characterized by very short telomeres caused by germline pathogenic variants in telomere biology genes. Clinical presentations can affect all organs, and inheritance patterns inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfc8119048751e0ebc708cc8cb92067
https://pubmed.ncbi.nlm.nih.gov/35323880
https://pubmed.ncbi.nlm.nih.gov/35323880
Autor:
Andrew J. Bauer, Jill Koshiol, Shahinaz M. Gadalla, Youjin Wang, Mark H. Greene, Ruth M. Pfeiffer, Min Zhan, Kathryn R. Wagner, Lesley A. Anderson, Rotana Alsaggaf, Sania Amr, Zhiwei Liu, Diane Marie M. St. George
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1510-1518 (2019)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
Objectives Recent evidence showed that myotonic dystrophy type I (DM1) patients are at increased risk of certain cancers, but the risk of benign tumors is unknown. We compared the risk of benign tumors in DM1 patients with matched DM1‐free individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e550bbb8be82fe8eed49756120403fca
https://doi.org/10.1002/acn3.50856
https://doi.org/10.1002/acn3.50856
Autor:
Stephen R. Spellman, Rotana Alsaggaf, Shilpa Katta, Bin Zhu, Steve Horvath, Shahinaz M. Gadalla, Stephanie J. Lee, Tao Wang, Belynda Hicks
Publikováno v:
Transplant Cell Ther
Cellular aging in hematopoietic cell transplantation (HCT) is important in the context of immune reconstitution and age-related complications. Recently, several DNA-methylation (DNAm)–based biomarkers of aging known as "epigenetic clocks" have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fadc06a86b32abbdcd5daf915df63de
https://pubmed.ncbi.nlm.nih.gov/33836872
https://pubmed.ncbi.nlm.nih.gov/33836872
Autor:
Katherine A. McGlynn, Rotana Alsaggaf, Zhiwei Liu, Lesley A. Anderson, Sam M. Mbulaiteye, Huei Ting Tsai, Bin Zhu, Shahinaz M. Gadalla, Jill Koshiol, Yue Zhu
Publikováno v:
Gut. 68:1458-1464
ObjectiveTo evaluate the association between statin use and risk of biliary tract cancers (BTC).DesignThis is a nested case–control study conducted in the UK Clinical Practice Research Datalink. We included cases diagnosed with incident primary BTC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744edd89ea29eb57ea075bc5aac7c7bb
https://doi.org/10.1136/gutjnl-2018-317504
https://doi.org/10.1136/gutjnl-2018-317504