Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rotamase activity"'
Curcacycline B, a cyclic nonapeptide from Jatropha curcas enhancing rotamase activity of cyclophilin
Autor:
Catherine Auvin, Françoise Lezenven, Alain Blond, Jean-Louis Pousset, Carine Baraguey, Bernard Bodo
Publikováno v:
Tetrahedron Letters. 38:2845-2848
The structure of curcacycline B (1), a cyclic nonapeptide isolated from Jatropha curcas latex was elucidated by combination of chemical degradation, LSIMS data and 2D NMR experiments. Curcacycline B was shown to enhance the rotamase activity of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72697d8fdaea06ac03fe6462f4a76584
https://doi.org/10.1016/s0040-4039(97)00495-4
https://doi.org/10.1016/s0040-4039(97)00495-4
Autor:
J. V. French, Richard E. Showalter, Hans E. Parge, Vincent J. Kalish, Daniel R. Knighton, John H. Tatlock, Christina T. Lewis, J. Ernest Villafranca
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2489-2494
The preparation and evaluation of potent small molecule inhibitors of FKBP-12 rotamase activity is described. These ligands contain many of the structural features of the FK506 pyranose ring region, yet are synthetically more accessible. The versatil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ce686745ca70ec16a529ff6519260e
https://doi.org/10.1016/0960-894x(95)00429-w
https://doi.org/10.1016/0960-894x(95)00429-w
Autor:
Bernard Bodo, Jean-Louis Pousset, Catherine Auvin, Françoise Lezenven, Carine Baraguey, Alain Blond
Publikováno v:
ChemInform. 28
The structure of curcacycline B (1), a cyclic nonapeptide isolated from Jatropha curcas latex was elucidated by combination of chemical degradation, LSIMS data and 2D NMR experiments. Curcacycline B was shown to enhance the rotamase activity of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::004bc2991708d7a6b29feb6fb1fb45c9
https://doi.org/10.1002/chin.199731181
https://doi.org/10.1002/chin.199731181
Publikováno v:
Clinical Biochemistry. 30:497-499
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeec60731ec22dc0dede49d5b13ff5ce
https://doi.org/10.1016/s0009-9120(97)00052-0
https://doi.org/10.1016/s0009-9120(97)00052-0
Autor:
Steven J. Soldin
Publikováno v:
Therapeutic Drug Monitoring. 17:574-576
The major immunophilins that bind cyclosporine (cyclophilin) and FK-506/rapamycin (FK-BP12) have been well characterized. They possess rotamase activity, which is inhibited by the immunosuppressant that binds to them. The immunosuppressive action doe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c041d26e44e84265e3f7d04b4fb5b1
https://doi.org/10.1097/00007691-199512000-00005
https://doi.org/10.1097/00007691-199512000-00005
Autor:
Todd A. Verdoorn, Jonathan L. Ditta, Sagarika Bollini, John J. Herbst, Alexander Vinitsky, Gene M. Dubowchik, G. T. Gaughan
Publikováno v:
Journal of biomolecular screening. 7(6)
FKBP12 is best known as the target of the widely used immunosuppressive drug FK506 but may also play a role in neuronal survival. Nonimmunosuppressive ligands of FKBP12 have been shown to have neuroprotective and neuroregenerative activity both in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f576416adb3b9202be656ed061c81d
https://pubmed.ncbi.nlm.nih.gov/14599350
https://pubmed.ncbi.nlm.nih.gov/14599350
Like cyclosporin A, cyclolinopeptide A binds specifically bovine cyclophilin A, inhibiting its peptidyl-prolyl cis-trans isomerase activity. We describe the protein interaction with several synthetic analogues of cyclolinopeptide A in terms of dissoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::397a44e676250b92f3f55bc4dce41c1f
http://hdl.handle.net/11588/458884
http://hdl.handle.net/11588/458884
Publikováno v:
Therapeutic Drug Monitoring. 19:558
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5370b9a40bc24bf0046ac81bb61a5934
https://doi.org/10.1097/00007691-199710000-00056
https://doi.org/10.1097/00007691-199710000-00056
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